Simultaneous determination of artificial sweeteners, preservatives, caffeine, theobromine and theophylline in food and pharmaceutical preparations by ion chromatography

Simultaneous Determination of Caffeine and Aspartame in Diet Supplements and Non-Alcoholic Beverages Using Liquid-Chromatography Coupled to Corona CAD and UV-DAD Detectors

“…High-performance liquid chromatography (HPLC) has been the most popular choice for the determination of additives (Wasik et al 2007;Zygler et al 2011;; however, other analytical methods have also been applied in their analysis (Bergamo et al 2011;Chen and Wang 2001;Zhu et al 2005) but the method using HPLC-Corona charged aerosol detector (CAD) has not been reported up-to-date. The Corona CAD is a new type of detector introduced for HPLC applications and has recently become widely used (Błażewicz et al 2010;Eom et al 2010;Kou et al 2009;Lísa et al 2007;Nováková et al 2009;Schönherr et al 2009;Takahashi et al 2008;Vervoort et al 2008).…”

Voltammetric Bioassay of Caffeine using Sensor Implant

“…For these reasons, instrumental techniques are in demand for performing simple and low DL of caffeine, which are very important for controls used in medical treatments (Concas et al 2000), food supply (Specterman et al 2005), leaf antioxidant assay (Liang et al 2007;Ismail et al 2000), treatment of Alzheimer's disease (Arendash et al 2006), and EEG skin response (Dixit et al 2006). Biological assay involves various separation and photometric analytical methods, including the reversed-phase HPLC technique (Ferreyra and Ortiz 2001;Pistos and Stewart 2004;Safranow and Machoy 2005), UV method (0.3 mg -1 DL) (Koch et al 1999), capillary gas chromatography (Pagliarussi et al 2002), electrophoresis UV detection (Maeso et al 2006), GC ion trap mass spectrometry (Verenitch et al 2006), FTIR spectrometry (Mashkouri Najafi et al 2003), LC-APCI-MS method (Gardinali and Zhao 2002), solid-phase FT Raman (18 mg l -1 DL) (Armenta et al 2005), LC diode array (Aresta et al 2005), ion chromatography (Chen and Wang 2001), Piezoelectric quartz sensor Zougagh et al 2005;, and HPLC diode array (Santos et al 2005). Although some of these methods can attain low DLs, these methods require separation, photometric, and data amplifications.…”

Investigation of sorbic acid volatile degradation products in pharmaceutical formulations using static headspace gas chromatography

“…The preservatives used in pharmaceuticals are strictly controlled by the respective regulatory organizations, preferring specific test methods for preservatives. There have been several methods published for the determination of the sorbic acid content in pharmaceutical and food preparations using different analytical techniques such as iodometric titration [17], polarimetry [18], UV-vis spectrometry [19][20][21][22], thinlayer chromatography [23], liquid chromatography [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39], gas chromatography [40][41][42][43][44][45][46][47][48][49] and capillary electrophoresis [50][51][52][53][54][55]. For the investigation of the degradation products in the past, the analytical techniques used were: UV spectroscopy and thin-layer chromatography (TLC).…”