Simultaneous determination of 13 quinolones from feeds using accelerated solvent extraction and liquid chromatography

Pecorelli, Ivan; Galarini, Roberta; Bibi, Rita; Floridi, Al.; Casciarri, E.

doi:10.1016/s0003-2670(02)01401-0

Cited by 100 publications

(54 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As a result these should not be found in animal feeds. While there are single class methods for the analysis of some of compounds [Vincent et al, 2008;Galarini et al, 2009;Pecorelli et al, 2003;Barbosa et al, 2007;van Holthoon et al, 2010] [Dusi et al, 2000], amprolium/ethopabate [Tan et al, 1996] and carbadox [Kesiunaite et al, 2008;Hutchinson et al, 2005] while for compounds such as dinitolimide no a Dublin Institute of Technology,School of Chemical and Pharmaceutical Sciences,Kevin Street,Dublin 8,Ireland b State Laboratory,Young's Cross,Backweston Campus,Backweston,Celbridge,Co. Kildare,Ireland.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a rapid multi-class method for the confirmation of fourteen prohibited medicinal additives in pig and poultry compound feed by liquid chromatography–tandem mass spectrometry

Cronly

Behan²,

Foley³

et al. 2010

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

A confirmatory method has been developed to allow for the analysis of fourteen prohibited medicinal additives in pig and poultry compound feed. These compounds are prohibited for use as feed additives although some are still authorised for use in medicated feed. Feed samples are extracted by acetonitrile with addition of sodium sulphate. The extracts undergo a hexane wash to aid with sample purification. The extracts are then evaporated to dryness and reconstituted in initial mobile phase. The samples undergo an ultracentrifugation step prior to injection onto the LC-MS/MS system and are analysed in a run time of 26 minutes. The LC-MS/MS system is run in MRM mode with both positive and negative electrospray ionisation. The method was validated over three days and is capable of quantitatively analysing for metronidazole, dimetridazole, ronidazole, ipronidazole, chloramphenicol, sulfadiazine, sulfamethazine, dinitolimide, ethopabate, carbadox and clopidol. The method is also capable of qualitatively analysing for tylosin, virginiamycin and avilamycin. A level of 100 µg kg -1 was used for validation purposes and the method is capable of analysing to this level for all the compounds. Validation criteria of trueness, precision, repeatability and reproducibility along with measurement uncertainty are calculated for all analytes.

show abstract

Section: Introductionmentioning

confidence: 99%

Development and validation of a rapid multi-class method for the confirmation of fourteen prohibited medicinal additives in pig and poultry compound feed by liquid chromatography–tandem mass spectrometry

Cronly

Behan²,

Foley³

et al. 2010

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

show abstract

“…The Gilson ASPEC XL TM is a typical example of an automated off-line SPE system that can process four samples in parallel in cartridge and 96-well format. A number of applications have been developed using this platform including anabolic steroids in urine [147,148]; quinolones in animal feed [149], seafood [150], bovine plasma, milk and tissues [151]; stilbenes in animal tissues [152]; sulphonamides in ovine plasma [153]; macrocyclic lactones in liver [154] and plasma [155,156]; benzimidazoles in bovine liver [106]; halofuginone in chicken liver and eggs [157]; malachite green in trout muscle [158]; carbadox and olaquindox in porcine liver [159].…”

Section: Automated Off-line/on-line Spementioning

confidence: 99%

Current trends in sample preparation for growth promoter and veterinary drug residue analysis

Kinsella

O’Mahony

Malone

et al. 2009

Journal of Chromatography A

175

View full text Add to dashboard Cite

A comprehensive review is presented on the current trends in sample preparation for isolation of veterinary drugs and growth promotors from foods. The objective of the review is to firstly give an overview of the sample preparation techniques that are applied in field. The review will focus on new techniques and technologies, which improve efficiency and coverage of residues. The underlying theme to the paper is the developments that have been made in multi-residue methods and particularly multi-class methods for residues of licensed animal health products, which have been developed in the last couple of years. The role of multi-class methods is discussed and how they can be accommodated in future residue surveillance.

show abstract

“…As Tabelas 4 e 5 relacionam os fármacos que têm sido quantificados empregando métodos de separação como CLAE [161][162][163][164][165][166][167][168][169][170][171][172][173][174][175][176][177] (Tabela 4) e eletroforese capilar 50,[178][179][180][181] (Tabela 5) na análise de amostras complexas, como plasma e urina, ou na quantificação de misturas de fármacos e em estudos relacionados com bioequiva-lência, farmacocinêtica e biodisponibilidade. Desta forma, estas técnicas apresentam grande potencialidade de uso em situações específicas onde a matriz da amostra seja muito complexa.…”

Section: Emprego De Técnicas De Separação Com Detecção Fluorimétricaunclassified

Aplicação e avanços da espectroscopia de luminescência em análises farmacêuticas

et al. 2008

View full text Add to dashboard Cite

Recebido em 20/10/06; aceito em 30/11/07; publicado na web em 4/9/08 APPLICATION AND ADVANCES IN THE LUMINESCENCE SPECTROSCOPY IN PHARMACEUTICAL ANALYSES. This paper provides a review on the latest advances and applications of the luminescence spectroscopy for the development of pharmaceuticals analyses methods, basically based on the photo-and chemiluminescence. The different forms of the drugs determination on pharmaceuticals through the fluorescence and chemiluminescence are discussed. The analyses include the drugs native fluorescence (liquid and solid-phases); the fluorescence from the oxidizing or reducing forms of the drug; the fluorescence from the chemical derivatization and their photochemistry and hydrolysis reactions. The quenching of luminescence and chemiluminescence generation for the pharmaceutical quantification are also shown. Finally, the trends and future perspectives of the luminescence spectroscopy in the field of the pharmaceutical research are discussed.Keywords: luminescence spectroscopy; drugs; cosmetics analysis; introdução Devido ao progresso contínuo em técnicas e instrumentos, a indústria farmacêutica busca o emprego de metodologias que ofereçam maior sensibilidade, seletividade, robustez, precisão, exatidão e rapidez. Neste sentido, um grande número de equipamentos de cromatografia líquida de alta eficiência (CLAE) com diversos tipos de detecção domina este ramo industrial. Contudo, o advento da sofisticação de instrumentação automatizada de espectrômetros de luminescência poderá resultar em um substancial aumento de aplicações desta técnica instrumental na indústria farmacêutica, principalmente, no que se refere à análise diretamente na matriz do medicamento.A espectroscopia de luminescência é uma ferramenta analítica extremamente sensível e tem sido amplamente aplicada na resolução de problemas que requerem baixos limites de detecção, podendo ser facilmente encontrados na literatura muitos trabalhos mostrando análises ao nível de traços.1-6 A sensibilidade inerente a esta técnica é consideravelmente maior em comparação a outras metodologias, entre elas a espectrofotometria UV/visível, apresentando limites de detecção de até três ordens de grandeza menores, os quais normalmente se encontram na faixa de ng mL -1 , sendo conseqüência do baixo sinal de fundo que as medidas fluorescentes apresentam. Diferentemente do que ocorre no fenômeno da luminescência, nas medidas de absorbância o sinal está associado à atenuação da intensidade de um feixe de radiação por uma espécie absorvente. Nos casos onde a quantidade da espécie é pequena, esta atenuação é menor, tornando assim a detecção da espécie difícil. Outra característica importante da luminescência diz respeito à seletividade, porque espécies com rendimentos quânticos de fluorescência apreciáveis são menos comuns do que substâncias cuja fluorescência não pode ser detectada. Desta forma, moléculas fluorescentes apresentam comprimento de onda característico de excitação e/ou emissão. Adicionalmente, o comprimento de onda de excitação d...

show abstract

Simultaneous determination of 13 quinolones from feeds using accelerated solvent extraction and liquid chromatography

Cited by 100 publications

References 7 publications

Development and validation of a rapid multi-class method for the confirmation of fourteen prohibited medicinal additives in pig and poultry compound feed by liquid chromatography–tandem mass spectrometry

Development and validation of a rapid multi-class method for the confirmation of fourteen prohibited medicinal additives in pig and poultry compound feed by liquid chromatography–tandem mass spectrometry

Current trends in sample preparation for growth promoter and veterinary drug residue analysis

Aplicação e avanços da espectroscopia de luminescência em análises farmacêuticas

Contact Info

Product

Resources

About