Simultaneous determination of 13 quinolone antibiotic derivatives in wastewater samples using solid‐phase extraction and ultra performance liquid chromatography–tandem mass spectrometry

Dorival-García, Noemí; Zafra-Gómez, Alberto; Cantarero, Samuel; Navalón, Alberto; Vı́lchez, J.L.

doi:10.1016/j.microc.2012.09.002

Cited by 95 publications

(58 citation statements)

References 47 publications

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“…Only CIPRO, LOME, and PIPE showed higher signal suppression effect. However, the selected ions for these quinolones were similar to those reported in bibliography for these compounds . Thus, this higher ME could be due to the presence of co‐eluting compounds (i.e., humic and fulvic acids), in agreement with other previously reported results .…”

Section: Resultssupporting

confidence: 91%

“…For the determination of quinolones in water, chromatographic methods with different detectors have been reported, such as HPLC coupled to fluorescence or diode array detection (DAD) . However, LC coupled to MS is the preferred technique for determination of antibiotics in water due to its high sensitivity and specificity . Regarding the sample treatment, SPE with C 18 , polymeric or anion exchange‐based sorbents has been used extensively for determination of quinolones in water .…”

Section: Introductionmentioning

confidence: 99%

“…However, LC coupled to MS is the preferred technique for determination of antibiotics in water due to its high sensitivity and specificity . Regarding the sample treatment, SPE with C 18 , polymeric or anion exchange‐based sorbents has been used extensively for determination of quinolones in water . Other treatments have also been proposed, such as SPME , dispersive liquid–liquid microextraction (DLLME) , molecular imprinted polymers (MIPs) , or stir bar sorptive extraction (SBSE) .…”

Section: Introductionmentioning

confidence: 99%

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Multiresidue analysis of quinolones in water by ultra-high perfomance liquid chromatography with tandem mass spectrometry using a simple and effective sample treatment

et al. 2014

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A rapid and simple analytical method has been developed for the determination of 19 quinolones in environmental water samples using ultra high performance liquid chromatography with tandem mass spectrometry. Chromatographic and detection conditions have been optimized and the separation was achieved in less than 4 min. The separation was carried out using a new-generation column filled with superficially porous particles, resulting in lower backpressure and better resolution than totally porous particle columns. The quinolones were detected by electrospray ionization in positive mode using multiple-reaction monitoring mode for acquisition. A sample treatment based on liquid-liquid extraction and phase separation via salting-out was employed to achieve a fast and simple extraction that enables the multiresidue analysis. The method has been validated for an environmental well water sample from a mountain area. Very low limits of detection (between 10 and 90 ng/L) with relative standard deviations lower than 16.5% and recoveries higher than 73% were achieved. Moreover, well waters from different origins (mountain and coast areas and irrigated land) have been evaluated and similar results were obtained.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multiresidue analysis of quinolones in water by ultra-high perfomance liquid chromatography with tandem mass spectrometry using a simple and effective sample treatment

et al. 2014

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“…The range is 0.29∼4.03 ng/L, which demonstrates a superior and stable detection limit especially when (Dorival-García et al 2013;Iglesias et al 2012;Panditi et al 2013). These results suggest that our optimized method is efficient for using in the simultaneous detection of four types of widely used antibiotics, SAs, TCs, QLs, and MALs.…”

Section: Determination Of MDLmentioning

confidence: 69%

Ultra-high performance liquid chromatography-electrospray tandem mass spectrometry for the analysis of antibiotic residues in environmental waters

Xue

Liu

2015

Environ Sci Pollut Res

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An optimized solid-phase extraction (SPE) and ultra-high performance liquid chromatography-electrospray tandem mass spectrometry (UPLC-MS/MS) method was developed for the effective analysis of 35 antibiotics including sulfonamides (SAs), quinolones (QLs), tetracyclines (TCs), macrolides (MALs), lincomycin (LIN), and chloramphenicol (CAP). The addition of 0.1% formic acid to the mobile phase was favorable for the formation of [M + H](+) and the enhancement in the detection signals, but using ammonium formate decreased [M + H](+) with a corresponding reduction in the response of CAP. The optimal pH range for the SPE was 4.5 ∼ 5.0 with 6 mL aqueous ammonia/methanol (5/95, v/v) as the optimized eluent. An internal standard (IS) was selected for each type of analytes based on similarities in classification and retention time. The detection was completed in less than 10 min and was excellent with method detection limits (MDL) of 0.29 ∼ 4.03 ng/L. The recoveries of the antibiotics in samples from ultrapure water and groundwater were 67.13 ∼ 93.00% and 68.91 ∼ 92.67%, respectively. The antibiotics in samples collected from wastewater, surface water, and groundwater were also effectively detected. This newly developed method has the advantages of short detection times, small sample consumption, excellent reproducibility, and high sensitivity. This provides a reliable and promising technique for the simultaneous detection and monitoring of various residual antibiotics in aqueous environmental samples.

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“…The interest in the determination of FQs from an environmental point of view is due to their wide use as broad spectrum antibiotics, which generate residues that are expected to enter the environment. In fact, a large number of pharmaceutical residues, including FQs, have been detected in environmental matrices such as waters and soils [13][14][15][16][17][18]. A revised guideline on environmental impact assessment for veterinary medicinal products has been published [19].…”

Section: Introductionmentioning

confidence: 99%

Determination of fluoroquinolone antibiotics by microchip capillary electrophoresis along with time-resolved sensitized luminescence of their terbium(III) complexes

2014

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We report on the time-resolved detection of the three fluoroquinolone (FQs) antibiotics ciprofloxacin (CIP), enrofloxacin (ENR) and flumequine (FLU). On addition of terbium(III) ions, the terbium(III)-FQs chelates are formed insitu in an on-capillary derivatization reaction of a microfluidic system. The laser-induced terbium(III)-sensitized luminescence of the chelates is measured at excitation/emission wavelengths of 337/545 nm. The analytes can be separated and quantified within less than 4 min. A solid phase extraction step for analyte preconcentration can be included prior to chelation and microchip capillary electrophoresis. The analytical ranges of the calibration graphs for CIP, ENR and FLU are from 10.6 to 60.0, 10.3 to 51.0, and 11.5 to 58.8 ng mL −1 , respectively, and the detection limits are 3.2, 3.1 and 3.6 ng mL −1 , respectively. The precision was established at two concentration levels of each analyte and revealed relative standard deviations in the range from 3.0 to 10.2 %. The method was applied to the analysis of FQ-spiked water samples.

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Simultaneous determination of 13 quinolone antibiotic derivatives in wastewater samples using solid‐phase extraction and ultra performance liquid chromatography–tandem mass spectrometry

Cited by 95 publications

References 47 publications

Multiresidue analysis of quinolones in water by ultra-high perfomance liquid chromatography with tandem mass spectrometry using a simple and effective sample treatment

Multiresidue analysis of quinolones in water by ultra-high perfomance liquid chromatography with tandem mass spectrometry using a simple and effective sample treatment

Ultra-high performance liquid chromatography-electrospray tandem mass spectrometry for the analysis of antibiotic residues in environmental waters

Determination of fluoroquinolone antibiotics by microchip capillary electrophoresis along with time-resolved sensitized luminescence of their terbium(III) complexes

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