Simultaneous circulation of Zika, Dengue, and Chikungunya viruses and their vertical co-transmission among Aedes aegypti

Teixeira, Adriano Fernandes; Brito, Breno Bittencourt de; Correia, Thiago Macêdo Lopes; Viana, Airton Idalécio Sousa; Carvalho, Juliana Cabral; Silva, Filipe Antônio França da; Santos, Maria Luísa Cordeiro; Silveira, Eliezer Almeida; Neto, Henry Paul Granger; Silva, Natalia Maria Pereira da; Rocha, Cínthya Viana Souza; Pinheiro, Fillipe Dantas; Chaves, Bárbara Aparecida; Monteiro, Wuelton Marcelo; Lacerda, Marcus Vinícius Guimarães; Secundino, Nágila Francinete Costa; Pimenta, Paulo Filemon Paolucci; Melo, Fabrício Freire de

doi:10.1016/j.actatropica.2020.105819

Cited by 13 publications

(14 citation statements)

References 26 publications

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“…Our findings showed natural VT of these arboviruses in this vector during the rainy season in Brumado, which is consistent with previous studies on these larvae in Brazil 9,10 . Three coinfected samples were identified in Regions 1 and 3 with two distinct arboviruses, making this the first report of simultaneous coinfection of DENV and CHIKV in A. aegypti larvae.…”

Section: Granger Neto Hp Et Al | Vertical Cotransmission In Aedes Aeg...supporting

confidence: 93%

Natural vertical cotransmission of Dengue virus and Chikungunya virus from Aedes aegypti in Brumado, Bahia, Brazil

Neto

Rocha

Correia

et al. 2022

Rev. Soc. Bras. Med. Trop.

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Background: Arthropod-borne viruses have recently emerged and are pathogens of various human diseases, including dengue, zika, and chikungunya viruses. Methods:We collected Aedes aegypti larvae (N = 20) from Brumado, Bahia, Brazil, and treated and individually preserved the specimens. We analyzed the samples for dengue, zika, and chikungunya viruses using molecular biology methods. Results:We found that 25% (N = 5) and 15% (N = 3) were positive exclusively for dengue and chikungunya viruses, respectively; 15% (N = 3) were coinfected with both.Conclusions: This is the first report of dengue and chikungunya virus coinfection in A. aegypti larvae.

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Section: Granger Neto Hp Et Al | Vertical Cotransmission In Aedes Aeg...supporting

confidence: 93%

Natural vertical cotransmission of Dengue virus and Chikungunya virus from Aedes aegypti in Brumado, Bahia, Brazil

Neto

Rocha

Correia

et al. 2022

Rev. Soc. Bras. Med. Trop.

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“… 2016 ; Teixeira et al. 2021 ). However, the possibility for individuals to be infected by two diseases simultaneously is quite small.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Modeling Syphilis and HIV Coinfection: A Case Study in the USA

Wang

Gao

et al. 2023

Bull Math Biol

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Syphilis and HIV infections form a dangerous combination. In this paper, we propose an epidemic model of HIV-syphilis coinfection. The model always has a unique disease-free equilibrium, which is stable when both reproduction numbers of syphilis and HIV are less than 1. If the reproduction number of syphilis (HIV) is greater than 1, there exists a unique boundary equilibrium of syphilis (HIV), which is locally stable if the invasion number of HIV (syphilis) is less than 1. Coexistence equilibrium exists and is stable when all reproduction numbers and invasion numbers are greater than 1. Using data of syphilis cases and HIV cases from the US, we estimated that both reproduction numbers for syphilis and HIV are slightly greater than 1, and the boundary equilibrium of syphilis is stable. In addition, we observed competition between the two diseases. Treatment for primary syphilis is more important in mitigating the transmission of syphilis. However, it might lead to increase of HIV cases. The results derived here could be adapted to other multi-disease scenarios in other regions.

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“…Subsequently, they must escape, disseminate and invade the salivary gland when the vector is able to transmit the arbovirus by a bite to a new host [ 31 ]. On the other hand, arboviruses can also be maternally transmitted by infected females to their offspring through the infection of germinal tissues [ 32 ].…”

Section: Aedes Spp: Understanding the Vector Interaction Wit...mentioning

confidence: 99%

Role of the Microbiome in Aedes spp. Vector Competence: What Do We Know?

Ferreira

Lemos

Moura

et al. 2023

Viruses

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Aedes aegypti and Aedes albopictus are the vectors of important arboviruses: dengue fever, chikungunya, Zika, and yellow fever. Female mosquitoes acquire arboviruses by feeding on the infected host blood, thus being able to transmit it to their offspring. The intrinsic ability of a vector to infect itself and transmit a pathogen is known as vector competence. Several factors influence the susceptibility of these females to be infected by these arboviruses, such as the activation of the innate immune system through the Toll, immunodeficiency (Imd), JAK-STAT pathways, and the interference of specific antiviral response pathways of RNAi. It is also believed that the presence of non-pathogenic microorganisms in the microbiota of these arthropods could influence this immune response, as it provides a baseline activation of the innate immune system, which may generate resistance against arboviruses. In addition, this microbiome has direct action against arboviruses, mainly due to the ability of Wolbachia spp. to block viral genome replication, added to the competition for resources within the mosquito organism. Despite major advances in the area, studies are still needed to evaluate the microbiota profiles of Aedes spp. and their vector competence, as well as further exploration of the individual roles of microbiome components in activating the innate immune system.

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Simultaneous circulation of Zika, Dengue, and Chikungunya viruses and their vertical co-transmission among Aedes aegypti

Cited by 13 publications

References 26 publications

Natural vertical cotransmission of Dengue virus and Chikungunya virus from Aedes aegypti in Brumado, Bahia, Brazil

Natural vertical cotransmission of Dengue virus and Chikungunya virus from Aedes aegypti in Brumado, Bahia, Brazil

Modeling Syphilis and HIV Coinfection: A Case Study in the USA

Role of the Microbiome in Aedes spp. Vector Competence: What Do We Know?

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