2012
DOI: 10.1002/rcm.6361
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Simultaneous characterization of prenylated flavonoids and isoflavonoids in Psoralea corylifolia L. by liquid chromatography with diode‐array detection and quadrupole time‐of‐flight mass spectrometry

Abstract: This method can be applied for analysis of prenylated components in P. corylifolia and other herbal medicines.

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Cited by 54 publications
(32 citation statements)
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“…The results of this study provide additional practice guidelines and justification for the administration of TCM as an adjuvant chemotherapy in resected early stage NSCLC patients727374757677787980.…”
Section: Discussionmentioning
confidence: 88%
“…The results of this study provide additional practice guidelines and justification for the administration of TCM as an adjuvant chemotherapy in resected early stage NSCLC patients727374757677787980.…”
Section: Discussionmentioning
confidence: 88%
“…In the MS 2 spectrum, the ion at m/z 321 was produced by the elimination of an H 2 O molecule from the ion at m/z 339 (Ma et al, 1997), and two abundant fragment ions at m/z 283 and 271 were generated ( Figure 3A). The ion at m/z 271 was produced by the elimination of the prenyl chain from the ion at m/z 339 (Xu et al, 2012), whereas the ion at m/z 283 was produced by the loss of isobutylene chain [(CH 3 ) 2 C ¼ CH 2 ] from the ion at m/z 339 (Su et al, 2015), which exhibited a stable benzyl structure (Nikolic et al, 2004). The preceding two pathways can be used for the inference of metabolism occurring in the prenyl group.…”
Section: Mass Spectral Fragmentation Of Bavachininmentioning
confidence: 98%
“…The ions at m/z 299, 287 and 163 were the three most abundant fragment ions. The ion at m/z 299 was produced by the loss of isobutylene chain [(CH 3 ) 2 C ¼ CH 2 ] from the ion at m/z 355 (Su et al, 2015), whereas the ion at m/ z 287 was formed by the elimination of prenyl chain from the ion at m/z 355 (Xu et al, 2012). The ion at m/z 163 ( 1,4 B + ) was also formed by a cleavage of bond 1,4 at ring C as bavachinin (Simons et al, 2009).…”
Section: Identification Of the Metabolites Of Bavachininmentioning
confidence: 99%
“…Prenylation usually renders flavonoids with improved bioactivities. The mechanism of action is prenylation increases the lipophilicity of flavonoids, which results in a higher affinity to biological membranes and a better interaction with target proteins (Xu et al, 2012). Depending on the length of prenyl side-chain and flavonoid skeletons, prenylated flavonoids have diverse structures.…”
Section: Introductionmentioning
confidence: 99%