Simultaneous Bilateral Testicular Germ Cell Tumors with Dissimilar Histology

Dieckmann, K.‐P.; Hamm, Bernd; Düe, W.; Bauer, H. W.

doi:10.1159/000281362

Cited by 20 publications

(11 citation statements)

References 12 publications

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“…In this article the incidence of bilateral seminoma was 50% (88 of 175) with 34% (59 of 175) of patients having discordant histology. This data is confirmed in other series [3, 4, 6, 9, 10]. …”

Section: Methodssupporting

confidence: 88%

“…[6], after a revision of the literature, reported a total of 151 cases of bilateral synchronous cancer, and 114 of these (75.5%) demonstrated seminoma in both testicles. By contrast, other authors reported an inversion of the incidence in the last years [4, 9].…”

Section: Methodsmentioning

confidence: 99%

“…Approximately 65–75% of these bilateral tumours are metachronous [4, 5]. The majority are seminomas, and they are histologically almost always identical [6–8]. Patients with bilateral testicular tumours, synchronous or metachronous, present with different problems requiring careful management to permit a good quality of life.…”

Section: Introductionmentioning

confidence: 99%

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Synchronous bilateral testis cancer: clinical and oncological management

Campobasso¹,

Ferretti

Frattini³

2017

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Synchronous bilateral testis cancer (SBTC) is a rare event. It represents only 0.5–1% of all new cases of testicular cancer. Patients with this disease require careful management for psychological, oncological, and medical problems.We performed a PubMed search for all series that reported SBTC. We considered only articles in English, reporting on more than three cases. We also performed an analysis of the reported evidence regarding testosterone replacement and surgical treatment.We found 10 studies satisfying inclusion criteria for a total of 73 patients. The majority are bilateral seminoma, which present with a low stage at diagnosis, and mixed histology tumours, both with a good overall survival. On the other hand, cases with bilateral non-seminoma histology are associated with poor prognosis and high stage at presentation.Testis-sparing surgery should be an eligible choice in selected cases, to preserve fertility and avoid testosterone deficiency. Multiple biopsies are recommended in these patients, and in the case of intratubular germ cell neoplasia (ITGCN) presence, scrotal radiotherapy is mandatory. Subcutaneous testosterone pellets guarantee higher patient acceptance and physiological testosterone levels. Lifelong follow-up and psychological support, with special care for infertility and erectile dysfunction, must be considered in this cohort of patients.

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Section: Methodssupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

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Synchronous bilateral testis cancer: clinical and oncological management

Campobasso¹,

Ferretti

Frattini³

2017

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“…Simultaneous development occurred in 111 of 689 cases of bilateral TGCT (16.1%) reported in 29 studies published since the early eighties (Table III). Dieckmann et al [46], in their review of the world literature through 1988, reported a total of 151 cases of bilateral synchronous cancer and 114 of these (75.5%) demonstrated seminoma in both testicles. Only 19 patients (12.6%) had different histologic findings.…”

Section: Discussionmentioning

confidence: 99%

Management and outcome of bilateral testicular germ cell tumors: Twenty-five year experience in Munich

Hentrich

Weber²,

Bergsdorf

et al. 2005

Acta Oncologica

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“…Die Prävalenz kontralateraler Hodentumoren wird mit 2 bis 5,8 % angegeben [9]. Das Risiko für einen Hodenzweittumor ist im Vergleich mit einer Gruppe gesunder Männer 500fach erhöht [25].…”

Section: Diskussionunclassified

Spätes Auftreten eines metachronen bilateralen Hodentumors und eines keimzellunabhängigen Zweittumors - Late Onset of Metachronous Bilateral Testicular Tumor and Secondary Non-Germ-Cell Malignancy -

Manny¹,

Thon²,

Brüschke³

et al. 1999

Akt Urol

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ZusammenfassungNach einer großen Tumorregisterstudie wird das 15 Jahre kumulative Risiko eines asynchronen bilateralen Keimzelltumors mit 3,9 % angegeben [29]. Im Vergleich mit der Allgemeinbevölkerung ist das relative Risiko (RR) 36fach erhöht [27]. Die Inzidenz eines kontralateralen Tumors korreliert eng mit dem Nachweis einer testikulären intraepithelialen Neoplasie (TIN). Hodentumorpatienten haben zusätzlich ein erhöhtes Risiko für das Auftreten eines keimzellunabhängigen Zweittumors, insbesondere Patienten, die radiotherapiert wurden. Wir berichten über einen 61 Jahre alten Mann mit einem asynchronen kontralateralen Seminom 29 Jahre nach Orchiektomie wegen eines Teratoblastoms und partieller Lungenresektion einer Lungenmetastase und Nachbestrahlung. Zwei keimzellunabhängige intestinale Zweittumoren (Sigma-und Rektumkarzinom) wurden ein Jahr vor der kontralateralen Orchiektomie durch eine Sigma-Rektumexstirpation behandelt. Der Patient verstarb zwei Jahre später postoperativ nach einer ausgedehnten intraabdominellen Debulking Operation des metastasierten kolorektalen Karzinoms. AbstractIn a large tumor registry study the 15-year cumulative risk of developing a second germ cell tumor for patients previously treated for testis cancer is reported to be 3.9 % [29]. The relative risk is 36-times higher than in the general population [27]. The incidence of a contralateral tumor is closely related to the presence of testicular intraepithelial neoplasia (TIN). Testis cancer patients are also known to be at an increased risk of developing a second non-germ malignandy, especially in patients previously treated with radiotherapy. We report a 61 year old man with an asynchronous contralateral seminoma 29 years after orchiectomy for teratoblastoma and partial lung resection and radiotherapy of lung metastasis. Two second non-germ cell intestinal carcinoma (sigma and rectum) were treated by sigma-rectum exstirpation one year before contralateral orchiectomy. The patient died two years later after intraabdominal debulking surgery of metastatic disease of the colorectal carcinoma.

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Simultaneous Bilateral Testicular Germ Cell Tumors with Dissimilar Histology

Cited by 20 publications

References 12 publications

Synchronous bilateral testis cancer: clinical and oncological management

Synchronous bilateral testis cancer: clinical and oncological management

Management and outcome of bilateral testicular germ cell tumors: Twenty-five year experience in Munich

Spätes Auftreten eines metachronen bilateralen Hodentumors und eines keimzellunabhängigen Zweittumors - Late Onset of Metachronous Bilateral Testicular Tumor and Secondary Non-Germ-Cell Malignancy -

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