Simultaneous Application of Photothermal Therapy and an Anti‐inflammatory Prodrug using Pyrene–Aspirin‐Loaded Gold Nanorod Graphitic Nanocapsules

Dong, Qian; Wang, Xuewei; Hu, Xiaoxiao; Xiao, Langqiu; Zhang, Liang; Song, Lijuan; Xu, Minglu; Zou, Yuxiu; Chen, Long; Chen, Zhuo; Tan, Weihong

doi:10.1002/anie.201709648

Cited by 185 publications

(111 citation statements)

References 28 publications

(19 reference statements)

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“…In PDT, photosensitizers generate ROS such as singlet oxygen ( 1 O 2 ), superoxide, hydrogen peroxide, and hydroxyl radical under light stimulation to kill cancer or inflammatory cells 120–122. In parallel, the photothermal conversion agents covert NIR light into localized heat for destroying disease regions 123,124. For RA treatment, NIR light with particular penetration depth can penetrate the inflamed joints, ensuring the treatment effect of nanomaterials in PDT and PTT 125…”

Section: Nanotherapeutics Of Ra Based On Nanodrugsmentioning

confidence: 99%

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Wang

Meng

et al. 2020

Adv Healthcare Materials

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Early diagnosis, standardized treatment, and regular monitoring are the clinical treatment principle of rheumatoid arthritis (RA). The overarching principles and recommendations of treat‐to‐target (T2T) in RA advocate remission as the optimum aim, especially for patients with very early disease who are initiating therapy with anti‐RA medications. However, traditional anti‐RA drugs cannot selectively target the inflammatory areas and may cause serious side effects due to its short biological half‐life and poor bioavailability. These limitations have significantly driven the research and application of nanomaterial‐based drugs in theranostics of RA. Nanomedicines have appropriate sizes and easily modified surfaces which can enhance their biological compatibility and prolong circulation time of drug‐loading systems in vivo. Traditional T2T regimens cannot evaluate the efficacy of drugs in real time, while clinical drug nanosizing can realize the integration of diagnosis and treatment of RA. This review bridges clinically proposed T2T concepts and nanomedicine in an integrated system for RA early‐stage diagnosis and treatment. The most advanced progress in various nanodrug delivery systems for theranostics of RA is summarized, establishing a clear path and a new perspective for further optimization of T2T. Finally, the key facing challenges are discussed and prospects are addressed.

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Section: Nanotherapeutics Of Ra Based On Nanodrugsmentioning

confidence: 99%

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Wang

Meng

et al. 2020

Adv Healthcare Materials

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“…The agents should be able to efficiently transfer the absorbed NIR light energy into heat. Various nanomaterials with strong NIR light harvesting ability were reported to be promising in photothermal transferring treatment of cancer, such as (1) noble metal-based nanostructures, including gold nanoparticles, [8][9][10][11] nanorods, 12,13 nanoshells, 14 nanocages, 15,16 and Pd nanomaterials; 17,18 (2) carbon-based nanostructures such as carbon nanotubes, 19,20 nanohorns, 21 and graphenes; 22 (3) organic dye compound, including melanin, 23 indocyanine green (ICG), 24 nanoscale coordination polymers 25 and polypyrrole; 26 (4) oxygen vacancy-rich transition metal compounds, 27 including W 18 O 49 , 28,29 MoO 3Àx , 30 MoSe 2 (ref. 31) and Cu 3 BiS 3 (ref.…”

Section: Introductionmentioning

confidence: 99%

Metallic Ti₃O₅ hierarchical porous microspheres with an enhanced photothermal property

Liu

Bai

et al. 2020

RSC Adv.

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“…As a type of novel graphite nanomaterial with a core–shell structure, superior physicochemical properties, good biocompatibility, superior stability, and controllable size, graphitic nanocapsules have been extensively applied in biosensing, bioimaging, drug delivery, and cancer treatment . Benefiting from the large surface area of the outside graphitic shell, graphitic nanocapsules supply superior nanoplatforms for drugs and targeting‐molecule loading, which further broadens their biomedical applications .…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Multifunctional Graphitic Nanocapsules for Raman Detection, Imaging, and Therapy

Liu

Zhu

et al. 2019

Small Methods

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To date, a variety of graphitic nanomaterial-based applications have facilitated the development of biomedical applications, such as carbon quantumdot-based biosensors and imaging systems, [14][15][16][17] graphene oxide-based biosensors [18][19][20][21][22] and drug delivery systems, [20,[23][24][25] and carbon nanotube-based therapy applications. [26][27][28][29] Compared with other widely used nanomaterials, graphitic nanomaterials show superior fluorescence quenching performance, larger Raman scattering cross-sections than conventional organic Raman tags, [30] and better biocompatibility. [31] With the goal of broadening their applications, great attention has been focused on integrating graphitic materials with other inorganic nanomaterials such as noble metals [32,33] and magnetic nanomaterials. [34,35] Such graphitic nanomaterial-metal hybrid nanostructures make full use of the excellent properties of both graphitic and metal nanomaterials, and have much wider application prospect in bioanalysis. [36] However, most of the reported hybrid nanostructures, in which metal nanomaterials are exposed on the surface of graphitic nanomaterials encounter difficulty in maintaining their morphologies and stable properties under harsh conditions, such as long-term laser irradiation or strong acidic environments, which might cause inaccurate bioanalytical results and even potential biotoxicity. [37][38][39] Therefore, it is critical to prepare novel graphitic nanomaterials with superstability to meet the demands of reliable bioanalysis and biomedicine.As a type of novel graphite nanomaterial with a core-shell structure, superior physicochemical properties, good biocompatibility, superior stability, and controllable size, graphitic nanocapsules have been extensively applied in biosensing, [40,41] bioimaging, [42,43] drug delivery, [43,44] and cancer treatment. [45] Benefiting from the large surface area of the outside graphitic shell, graphitic nanocapsules supply superior nanoplatforms for drugs and targeting-molecule loading, which further broadens their biomedical applications. [42,44,46] In addition, the graphitic shell of graphitic nanocapsules possesses several unique Raman scattering bands and can act as a Raman signal tag or stable internal standard (IS) for accurate surface enhanced Raman scattering (SERS) analysis. [46,47] Particularly, the 2D band (≈2650 cm −1 ) within the cellular Raman-silent region is beneficial to avoiding the interference signals from Benefiting from their unique physicochemical properties, graphitic nanocapsules with a core-shell structure have attracted tremendous interest in bioanalysis and biomedicine recently. Using rational design, various types of graphitic nanocapsules with controllable properties are prepared to meet the demands of different biomedical applications. Graphitic nanocapsules exhibit excellent stability and superior capacity for loading nucleic acids, proteins, small molecules, and drugs due to the large specific surface area of their graphitic shells. Moreover, usin...

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Simultaneous Application of Photothermal Therapy and an Anti‐inflammatory Prodrug using Pyrene–Aspirin‐Loaded Gold Nanorod Graphitic Nanocapsules

Cited by 185 publications

References 28 publications

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Metallic Ti₃O₅ hierarchical porous microspheres with an enhanced photothermal property

Recent Advances in Multifunctional Graphitic Nanocapsules for Raman Detection, Imaging, and Therapy

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Simultaneous Application of Photothermal Therapy and an Anti‐inflammatory Prodrug using Pyrene–Aspirin‐Loaded Gold Nanorod Graphitic Nanocapsules

Cited by 185 publications

References 28 publications

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Metallic Ti3O5 hierarchical porous microspheres with an enhanced photothermal property

Recent Advances in Multifunctional Graphitic Nanocapsules for Raman Detection, Imaging, and Therapy

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Metallic Ti₃O₅ hierarchical porous microspheres with an enhanced photothermal property