Simultaneous and sensitive detection of acetaminophen and valacyclovir based on two dimensional graphene nanosheets

Adhikari, Bal-Ram; Maduraiveeran, Govindhan; Schraft, Heidi; Chen, Aicheng

doi:10.1016/j.jelechem.2016.09.023

Cited by 44 publications

(16 citation statements)

References 51 publications

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“…The limit of detection (LOD) was further calculated to be 0.018 µM using the formula 3 σ/s , where σ denotes the standard deviation of three blank measurements and s represents the slope calculated from the calibration plot. The two calibration plots acquired in this study were similar to studies that involved the measurement of molecules, such as acetaminophen and valacyclovir, ascorbic acid, dopamine, uric acid, and NADH [25,59,71,72]. This observation might be explained based on the mechanism of the inner-sphere electrode reaction [25,73].…”

Section: Resultssupporting

confidence: 72%

“…The two calibration plots acquired in this study were similar to studies that involved the measurement of molecules, such as acetaminophen and valacyclovir, ascorbic acid, dopamine, uric acid, and NADH [25,59,71,72]. This observation might be explained based on the mechanism of the inner-sphere electrode reaction [25,73]. Important attributes such as the novelty analytical advantages and capabilities (e.g., linear range and LOD) of the developed F-GO/GCE electrochemical sensor were confirmed by comparing the performance of the CA sensors formerly reported in the literature as shown in Table 1.…”

Section: Resultsmentioning

confidence: 59%

“…As noble metals are expensive, carbon-based electrochemical sensors offer an inexpensive route toward the quantification of CA. Graphene and its derivatives are widely used in biological applications, electrochemical sensing, and energy storage due to their remarkable physicochemical properties [24,25,26,27,28,29,30,31,32,33,34,35,36]. Array-based sensing approaches (nose/tongue strategies) using graphene oxide have been reported for the detection of biomatrices and organic molecules [37,38,39].…”

Section: Introductionmentioning

confidence: 99%

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Sensitive Electrochemical Detection of Caffeic Acid in Wine Based on Fluorine-Doped Graphene Oxide

Manikandan

Boopathi

Thiruppathi

et al. 2019

Sensors

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We report here a novel electrochemical sensor developed using fluorine-doped graphene oxide (F-GO) for the detection of caffeic acid (CA). The synthesized graphene oxide (GO) and F-GO nanomaterials were systematically characterized with a scanning electron microscope (SEM), and the presence of semi-ionic bonds was confirmed in the F-GO using X-ray photoelectron spectroscopy. The electrochemical behaviours of bare glassy carbon electrode (GCE), F-GO/GCE, and GO/GCE toward the oxidation of CA were studied using cyclic voltammetry (CV), and the results obtained from the CV investigation revealed that F-GO/GCE exhibited the highest electrochemically active surface area and electrocatalytic activity in contrast to the other electrodes. Differential pulse voltammetry (DPV) was employed for the analytical quantitation of CA, and the F-GO/GCE produced a stable oxidation signal over the selected CA concentration range (0.5 to 100.0 μM) with a low limit of detection of 0.018 μM. Furthermore, the acquired results from the selectivity studies revealed a strong anti-interference capability of the F-GO/GCE in the presence of other hydroxycinnamic acids and ascorbic acid. Moreover, the F-GO/GCE offered a good sensitivity, long-term stability, and an excellent reproducibility. The practical application of the electrochemical F-GO sensor was verified using various brands of commercially available wine. The developed electrochemical sensor successfully displayed its ability to directly detect CA in wine samples without pretreatment, making it a promising candidate for food and beverage quality control.

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Section: Resultssupporting

confidence: 72%

Section: Resultsmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

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Sensitive Electrochemical Detection of Caffeic Acid in Wine Based on Fluorine-Doped Graphene Oxide

Manikandan

Boopathi

Thiruppathi

et al. 2019

Sensors

Self Cite

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“…Apart from direct interactions with the virus, functionalized graphene is also used as a biosensor for the detection and diagnosis of viruses, as well as producing other therapeutics [96][97][98]. The remarkable specific surface area enables the manipulation of electrical properties of the single biomolecule which, in turn, could achieve single-molecule detection for viral infection [99].…”

Section: Graphenementioning

confidence: 99%

Insights into the Role of Graphene/Graphene‐hybrid Nanocomposites in Antiviral Therapy

Manickam²,

et al. 2021

ChemBioEng Reviews

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The recent coronavirus disease 2019 (COVID-19) pandemic outbreak has affected the lives of people globally on many different levels. Whilst a few antiviral drugs have been recommended for COVID-19, there are no dedicated drugs available for this disease, yet. A virus pandemic could potentially induce severe public health threats, as well as economic and social consequences. Therefore, the discovery of effective, safe, and inexpensive antiviral agents is of great importance. Graphene has extraordinary properties. A series of successful biomedical applications involving graphene/graphene-hybrid nanocomposites (G/GHNs) have been reported in recent years, including graphene-based biosensor and related drug delivery system. This review is focused on the properties, synthesis routes, and applications of G/GHNs in antiviral therapy aiming to understand and highlight the unique properties of graphene and its derivatives, particularly for antiviral therapy, to evaluate and discuss the quality of graphene prepared via various preparation methods, to present the recent development of G/GHNs and their antiviral activities in prevention, detection and treatment, to offer perspective outlooks on the role of G/GHNs in antiviral therapy.

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“…Despite the fact that these methods are sensitive in detection, they tend to be complicated, time‐consuming, and usually require specialized and expensive instruments. On the contrary, electrochemical techniques have been highly considered as a good alternative because of their simplicity, good stability, cheap but fast response, excellent sensitivity and selectivity [12]. For this reason, electrochemical techniques have been considered as a simple but powerful tool for either individual or simultaneous detections.…”

Section: Introductionmentioning

confidence: 99%

Graphene Nanocomposites Based Electrochemical Sensing Platform for Simultaneous Detection of Multi‐drugs

et al. 2021

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Three reduced graphene oxide nanocomposites were employed to achieve the simultaneous electrochemical determination of multi‐drugs including acetaminophen (ACTM), carbendazim (CB) and ciprofloxacin (CFX). All nanocomposite modified electrodes showed improved current responses for three drugs. Notably cauliflower‐like platinum nanoparticles decorated reduced graphene oxide modified electrode (or Pt−RGO/GCE) exhibited the best performance in terms of electrochemical stability. Using Pt−RGO/GCE, the linear detect ranges of 30–120 μM, 25–115 μM and 10–25 μM, and detection limit values of 3.49, 2.96, and 1.53 μM were achieved for ACTM, CB and CFX respectively. The electrode was further used for the successful determination of above drugs in tap and river water using differential pulse voltammetry. From the obtained results, we believe that Pt‐RGO/GCE is highly promising for the fabrication of robust electrochemical sensors for simultaneously determining ACTM, CB and CFX or similar types of drugs in the future.

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Simultaneous and sensitive detection of acetaminophen and valacyclovir based on two dimensional graphene nanosheets

Cited by 44 publications

References 51 publications

Sensitive Electrochemical Detection of Caffeic Acid in Wine Based on Fluorine-Doped Graphene Oxide

Sensitive Electrochemical Detection of Caffeic Acid in Wine Based on Fluorine-Doped Graphene Oxide

Insights into the Role of Graphene/Graphene‐hybrid Nanocomposites in Antiviral Therapy

Graphene Nanocomposites Based Electrochemical Sensing Platform for Simultaneous Detection of Multi‐drugs

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