Simultaneous and sensitive capillary electrophoretic enantioseparation of three β-blockers with the combination of achiral ionic liquid and dual CD derivatives

Jin, Yue; Chen, Cheng; Meng, Lingchen; Chen, Jitao; Li, Meixian; Zhu, Zhiwei

doi:10.1016/j.talanta.2011.12.005

Cited by 42 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is the most remarkable sensitivity improvement from all the works included in this review which is also the work reporting the lowest LOD (8–40 × 10 −11 M). The excellent sensitivity of this methodology is demonstrated when compared to previously reported works, this methodology being five times more sensitive than SPE‐HPLC and isotachophoresis CE methodologies and 30 times more sensitive than an FESI‐EKC method .…”

Section: Strategies To Enhance the Detection Sensitivitymentioning

confidence: 56%

Improving the sensitivity in chiral capillary electrophoresis

2015

View full text Add to dashboard Cite

CE is known for being one of the most powerful analytical techniques when performing enantioseparations due to its numerous advantages such as excellent separation efficiency and extremely low solvents and reagents consumption, all of them derived from the capillary small dimensions. Moreover, it is worth highlighting that unlike in chromatographic techniques, in CE the chiral selector is generally within the separation medium instead of being attached to the separation column which makes the method optimization a more versatile task. Despite its numerous advantages, when using UV-Vis detection, CE lacks of sensitivity detection due to its short optical path length derived from the narrow separation capillary. This issue can be overcome by means of different approaches, either by sample treatment procedures or by in-capillary preconcentration techniques or even by employing detection systems more sensitive than UV-Vis, such as LIF or MS. The present review assembles the latest contributions regarding improvements of sensitivity in chiral CE published from June 2013 until May 2015, which follows the works included in a previous review reported by Sánchez-Hernández et al. [Electrophoresis 2014, 35, 12-27].

show abstract

Section: Strategies To Enhance the Detection Sensitivitymentioning

confidence: 56%

Improving the sensitivity in chiral capillary electrophoresis

2015

View full text Add to dashboard Cite

show abstract

“…The LODs of the method, calculated as three times of S/N value, were 0.10, 0.10, 0.12, 0.11, 0.02, and 0.02 ng/mL for S ‐BU, R ‐BU, S ‐AL, R ‐AL, S ‐PRO, and R ‐PRO, respectively. Compared with the LOD of 0.4, 0.2 ∼ 0.5, and 29.6 ∼ 35.5 ng/mL in previous reports using SPE‐HPLC , t‐ITP‐CZE , and FESI‐CDCZE , respectively, the higher sensitivity of the method indicated its superior practical utility in trace content compounds in biological fluids.…”

Section: Resultsmentioning

confidence: 68%

Sensitive enantioanalysis of β‐blockers via field‐amplified sample injection combined with water removal in microemulsion electrokinetic chromatography

Zhang

Rahman

et al. 2014

Electrophoresis

View full text Add to dashboard Cite

In this study, an on-line sample preconcentration technique, field-amplified sample injection combined with water removal by electroosmotic flow (EOF) pump, was applied to realize a highly sensitive chiral analysis of β-blocker enantiomers by MEEKC. The introduction of a water plug in capillary before the electrokinetic injection provided the effective preconcentration of chiral compounds. And then the water was moving out of the column from the injection end under the effect of the EOF, which avoided dilution of the stacked β-blocker enantiomers concentration suffering from the presence of water in separation buffer. Moreover, the addition of H3 PO4 and methanol in the sample solution greatly improved the enhancement efficiency further. Under optimized conditions, more than 2700-fold enhancement in sensitivity was obtained for each enantiomer of bupranolol (BU), alprenolol (AL), and propranolol (PRO) via electrokinetic injection. LODs were 0.10, 0.10, 0.12, 0.11, 0.02, and 0.02 ng/mL for S-BU, R-BU, S-AL, R-AL, S-PRO, and R-PRO, respectively. Eventually, the proposed method was successfully applied to the determination of BU, AL, and PRO in serum samples with good recoveries ranging from 93.4 to 98.2%.

show abstract

“…Ionic liquids have emerged as important additives for chiral separation due to the fact that they are fairly nonvolatile, possess a rather large range of thermal stability, and have a variety of physical and chemical properties . Jin et al proposed a CE method for simultaneous enantioseparation of three β‐blockers including pindolol, oxprenolol, and propranolol using commercially available achiral ionic liquid, glycidyltrimethylammonium chloride, as a modifier to cooperate with CDs. During the separation, the positively charged glycidyltrimethylammonium cations were first covalently coated onto the capillary wall, which led to a surface charge reversal and thus reduces the EOF.…”

Section: Enantioseparation Of β‐Blockers By Means Of Capillary Electrmentioning

confidence: 99%

Recent developments in chiral analysis of β‐blocker drugs by capillary electromigration techniques

Zhang

Chen

et al. 2014

Electrophoresis

View full text Add to dashboard Cite

The latest developments in chiral analysis of β-blocker drugs by capillary electromigration techniques are reviewed in this article. Following the previous review by Aturki et al. [Electrophoresis 2011, 32, 2602-2628], this review includes the papers published during the period from January 2011 to December 2013. During this time, some novel chiral selectors were reported and applied to improve the enantioseparation of β-blocker drugs and structurally related compounds. These chiral selectors include CDs and their derivatives, macrocyclic antibiotics, tartrate complexs, the monolithic molecularly imprinted polymer, and the polymeric surfactants. In addition, this article summarizes the methodological improvements for enhancing sensitivity in chiral analysis of β-blockers and structurally related compounds by CE. The involved authors described the use of online sample preconcentration techniques to increase the detection sensitivity in the enantiomeric analysis of a broad range of samples.

show abstract

Simultaneous and sensitive capillary electrophoretic enantioseparation of three β-blockers with the combination of achiral ionic liquid and dual CD derivatives

Cited by 42 publications

References 23 publications

Improving the sensitivity in chiral capillary electrophoresis

Improving the sensitivity in chiral capillary electrophoresis

Sensitive enantioanalysis of β‐blockers via field‐amplified sample injection combined with water removal in microemulsion electrokinetic chromatography

Recent developments in chiral analysis of β‐blocker drugs by capillary electromigration techniques

Contact Info

Product

Resources

About