Simultaneous and rapid quantitation of benazepril and benazeprilat in human plasma by high performance liquid chromatography with ultraviolet detection

Wang, Xue Ding; Chan, Eli; Chen, Xiao; Liao, Xiao Xing; Tang, Cheng; Zhou, Zhi Wei; Huang, Min; Zhou, Shu Feng

doi:10.1016/j.jpba.2007.01.009

Cited by 9 publications

(1 citation statement)

References 23 publications

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“…spectrofluorimetric (Aktas et al, 2003;El-Gindy et al, 2001;El-Yazbi et al, 1999), bioanalytical (Shepley et al, 1988;Yuan et al, 1996), voltametric (Belal et al, 2001), high performance liquid chromatographic (HPLC) followed by spectrophotometric detection (Abou-Basha et al, 2003;Bonazzi et al, 1997;Cirilli and La Torre, 1998;El-Gindy et al, 2001;Wang et al, 2007) or spectrofluorimetric detection (El-Emam et al, 2004;Sagirli and Ersoy, 2004) and capillary electrophoresis (Gotti et al, 2000) methods. Gas (Leis et al, 1995;Xiao et al, 2005) and liquid (Huang et al, 2006;Kousoulos et al, 2005;Leis et al, 1999;Lu et al, 2009) chromatography-mass spectrometry methods were widely applied to ACE inhibitors and their metabolites determination in biological fluids due to their high sensitivity and selectivity.…”

Section: Introductionmentioning

confidence: 99%

Enhanced selectivity approach for fast analysis of enalaprilat, lisinopril and benazepril in pharmaceutical dosage forms and spiked human plasma by ion chromatography

Elsebaei¹

2013

Afr. J. Pharm. Pharmacol.

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A simple and highly selective method for determination of enalaprilat (ENT), lisinopril (LSP) and benazepril hydrochloride (BZP) in pharmaceutical dosage forms as well as spiked human plasma by ion chromatography with UV detection has been developed. ENT and LSP are compounds with little inherent hydrophobicity that make their analysis using HPLC essentially sophisticated necessitating either complex extraction procedures or especial detection methods. The method proposed is based upon ionization of those two drugs in basic medium to be well retained and readily resolved as dicarboxylic acid anions using IonPac AS11 (13 μm particle size, 4 × 250 mm, Dionex) anion exchange column adopting a very simple clean-up procedure via a single-step protein precipitation with UV detection at 215 nm. The three drugs were successfully determined in pharmaceutical dosage forms as well as in spiked human plasma with tyrosine as internal standard with a recovery approaching 100%. Adopting this proposed procedure, the analytes produce well shaped peaks with good linear relationship over the investigated concentration ranges and values of (r) higher than 0.998 for all drugs. ion level of200 ng ml-1 of the three drugs, therefore being satisfactory for their purposed analysis. The method was validated with respect to specificity, recovery, accuracy, precision and linearity. Moreover, the method could be applied to the determination of the drugs in pharmaceutical preparations. The method was validated with respect to specificity, recovery, accuracy, precision and linearity and the method proved applicable for routine fast analysis of the studied drugs.

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Section: Introductionmentioning

confidence: 99%

Enhanced selectivity approach for fast analysis of enalaprilat, lisinopril and benazepril in pharmaceutical dosage forms and spiked human plasma by ion chromatography

Elsebaei¹

2013

Afr. J. Pharm. Pharmacol.

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Quantitative estimation of riluzole in human plasma by LC-ESI-MS/MS and its application to a bioequivalence study

Chandu

Nama

Kanala³

et al. 2010

Anal Bioanal Chem

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A novel simple, sensitive, selective, and rapid high-performance liquid chromatography coupled with tandem mass spectrometry method was developed and validated for quantification of riluzole in human plasma. The chromatography was performed by using a Zorbax-SB-C18 (4.6 x 75 mm, 3.5 microm) column , isocratic mobile phase 0.1% formic acid/acetonitrile (10:90 v/v), and an isotope-labeled internal standard (IS), [(13)C,(15)N(2)]riluzole. The extraction of drug and internal standard was performed by liquid-liquid extraction and analyzed by MS in the multiple reaction monitoring (MRM) mode using the respective [M+H](+) ions, m/z 235.0/165.9 for riluzole and m/z 238.1/169.0 for the IS. The calibration curve was linear over the concentration range 0.5-500.0 ng/ml for riluzole in human plasma. The limit of quantification (LOQ) was demonstrated at 0.5 ng/ml. The within-batch and between-batch precision were 0.6-2.3% and 1.4-5.7%, and accuracy was 97.1-101.1% and 98.8-101.2% for riluzole respectively. Drug and IS were eluted within 3.0 min. The validated method was successfully applied in a bioequivalence study of riluzole in human plasma.

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Comparative study between univariate spectrophotometry and multivariate calibration as analytical tools for quantitation of Benazepril alone and in combination with Amlodipine

Farouk¹,

Elaziz²,

Tawakkol³

et al. 2014

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Simultaneous and rapid quantitation of benazepril and benazeprilat in human plasma by high performance liquid chromatography with ultraviolet detection

Cited by 9 publications

References 23 publications

Enhanced selectivity approach for fast analysis of enalaprilat, lisinopril and benazepril in pharmaceutical dosage forms and spiked human plasma by ion chromatography

Enhanced selectivity approach for fast analysis of enalaprilat, lisinopril and benazepril in pharmaceutical dosage forms and spiked human plasma by ion chromatography

Quantitative estimation of riluzole in human plasma by LC-ESI-MS/MS and its application to a bioequivalence study

Comparative study between univariate spectrophotometry and multivariate calibration as analytical tools for quantitation of Benazepril alone and in combination with Amlodipine

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