Simultaneous administration of Hepatitis B vaccine with other E.P.I. vaccines

Abstract

Development of recombinant DNA vaccine against hepatitis B grown on cultured yeast cell has made it possible to mount a world-wide effort to control and eradicate Hepatitis B infection. However, the currently recommended schedules (0, 1 & 2 months, and 0-1 and 6 months) do not coincide with the scheduled visits for other E.P.I. vaccines, and necessitate additional visits for Hepatitis B vaccination. This study was therefore carried out to find out if adequate seroconversion occurs to Hepatitis B vaccine when given with other EPI vaccines or not? Thirty nine infants born to Australia antigen positive mothers from among 850 screened pregnant mothers were recruited to receive Hepatitis B vaccine (Engerix B-10 micro gram each) at 0, 6 and 14 wks (group A) or at 0, 1 and 2 months (group B). Thirty-one infants were recruited in group A and 8 in group B. The cord blood was collected and the first dose of vaccine was given within 48 hours of birth. Simultaneous B.C.G. was given at the left deltoid. Other E.P.I. vaccines were given qt 6, 10 and 14 wks in group A and at 2, 3 and 4 months in group B. Repeat blood samples were collected prior to giving each dose of Hepatitis B vaccine, and 4 weeks after the last dose. All blood samples were assayed for HBsAg and HBsAb at the National Institute Of Communicable Diseases, utilizing standard ELISA kits. The seroconversion rates following one, two and three doses of Hepatitis B vaccine were 3.33%, 55.5%, 96.15% and 0%, 62.5% and 100% in group A and B respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Evaluation of potentially achievable vaccination coverage of the second dose of measles containing vaccine with simultaneous administration and risk factors for missed opportunities among children in Zhejiang province, east China

“…2 The recommendation of simultaneous administration is also considered to be an effective strategy for improving the vaccination coverage, acquiring and sustaining the national target of coverage level in other settings. [2][3][4] Extensive clinical practice and experimental evidence showed that administrating all age-appropriate vaccine doses simultaneously is safe and efficacious. [5][6][7] Coverage survey also indicated that failing to give all vaccine doses for which a child is eligible is one of the main reasons for lower coverage.…”

Estimation and Comparison of Immunization Coverage under Different Sampling Methods for Health Surveys

“…Hepatitis B vaccine was given within 12 hours of birth, then at 6 weeks and at 14 weeks [9]. This is to be noted that the children of Assam in the North-East Region of India have consistently evidenced low rates for routine childhood immunizations.…”