Tailoring the hydrodynamic boundary condition is essential for both applied and fundamental aspects of drag reduction. Hydrodynamic friction on superhydrophobic substrates providing gasliquid interfaces can potentially be optimized by controlling the interface geometry. Therefore, establishing stable and optimal interfaces is crucial but rather challenging. Here we present unique superhydrophobic microfluidic devices that allow the presence of stable and controllable microbubbles at the boundary of microchannels. We experimentally and numerically examine the effect of microbubble geometry on the slippage at high resolution. The effective slip length is obtained for a wide range of protrusion angles, θ, of the microbubbles into the flow, using a microparticle image velocimetry technique. Our numerical results reveal a maximum effective slip length, corresponding to a 23% drag reduction at an optimal θ ≈ 10°. In agreement with the simulation results, our measurements correspond to up to 21% drag reduction when θ is in the range of −2°to 12°. The experimental and numerical results reveal a decrease in slip length with increasing protrusion angles when θ ≳ 10°. Such microfluidic devices with tunable slippage are essential for the amplified interfacial transport of fluids and particles. D espite more than two decades of intense research on hydrodynamic slippage on substrates with various physicochemical properties (1-4), tuning the hydrodynamic slippage remains a challenge, especially for microfluidic laminar flow. The slip length-quantifying the slippage-ranges from a few nanometers for flat hydrophobic substrates to several micrometers for superhydrophobic substrates with hybrid (liquid-gas and liquidsolid) interfaces (4). Hydrophobic microstructures containing trapped gas bubbles have been shown to be advantageous for drag reduction (5-11). Their orientation with respect to the flow direction (12-16) and the geometry of gas-liquid menisci (11)(12)(13)(14)17) has been demonstrated to affect the slippage. In particular, microscale bubbles transverse to the flow direction can alter the flow resistance, depending on the protrusion of the bubbles into the flow. Moreover, transition from slippage to friction has been predicted for trapped bubbles perpendicular to the flow in theoretical (14, 18) and numerical studies (12,13,19,20). The presence of such a critical protrusion angle highlights the feasibility of manipulating the flow resistance via bubble geometry. One recent experimental study suggests that for flow over a hydrophobic surface with trapped passive microbubbles, there is a transition from an enhanced slippage state to the frictional state at a large protrusion angle, in an estimated range of 30°-60°(20). However, there has been no experimental investigation of flow past a hydrophobic surface with transversely embedded microbubbles for a wide range of protrusion angles at high resolution. In this paper, we report on integrated microfluidic devices that permit the presence of stable and controllable microbubb...