The robustness of different interactive schemes for demodulating M-ary orthogonal signaling formats in asynchronous DS-CDMA systems to the synchronization errors is addressed in this paper. The system under study resembles the uplink of an IS-95 system. The channel is assumed to be a time-varing flat Rayleigh-fading channel. Our simulation results show that performance degradation for the considered multiuser detectors increase linearly with synchronization errors and eventually converge to that of conventional matched filter. In order to see the impact of channel estimation on the performance of multiuser detectors, we made some comparisons between non-coherent and coherent variants of the detection algorithms.