Conventional talent selection algorithms for large enterprises mainly use induction and deduction to obtain selection competency characteristics, which is vulnerable to the influence of orientation consciousness, resulting in low matching degree of talent selection. Therefore, a new talent selection algorithm for large enterprises needs to be designed based on entropy weighted clustering mining. That is to say, based on entropy weighted clustering, a model for selecting talents in large enterprises is constructed, and an optimization algorithm for selecting talents in large enterprises is generated. The case analysis results show that the selection algorithm designed for the selection of outstanding talents in large enterprises has good selection effect, high selection matching degree, reliability and certain application value, and has made certain contributions to improving the comprehensive strength of Chinese enterprises and promoting the sustainable development of China.