Combination of constructed wetland with activated sludge (AS) is one of the application of sustainable development for dealing with environmental pollution. The objective of this study was to compare the performance of three system of domestic wastewater treatment, namely AS, combination AS with constructed wetland containing Canna lily (AS‐CWC), combination AS with constructed wetland containing Cyperus papyrus (AS‐CWP) for treating domestic wastewater. Mini pilot scale of treatment system was built under continuous flow. Samples were taken at outlet in each unit for measuring water quality parameters, such as BOD, TSS, PO43−, NH4+‐N and NO3−‐N. The results indicated that AS‐CWC performed a higher removal of BOD, PO43− and TSS than AS‐CWP and AS. AS‐CWC and AS‐CWP showed a statistically insignificant difference removal of NH4+‐N and NO3‐‐N, though the former performed a higher removal than the later. This study revealed that TOC increased in the highest percentage in AS and the lowest increasing in AS‐CWP. Constructed wetlands should be integrated with primary treatment to enhancing effluent quality and reduce organic matter, a precursors of carcinogenic compound.