Simulation of pseudo-clinical conditions and image quality evaluation of PET scanner based on pixelated CdTe detector

Mikhaylova, Ekaterina; Canadas, M.; Lorenzo, G. De; Chmeissani, M.; Arce, P.; Ariño, G; Cabruja, E.; Calderon, Yonatan; Kolstein, M.; Macias-Montero, Jose Gabriel; Martı́nez, Ricardo; Ozsahin, Ilker; Puigdengoles, C.; Uzun, D.

doi:10.1109/nssmic.2011.6152955

Cited by 12 publications

(19 citation statements)

References 4 publications

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“…The aim of this work is to prove the feasibility of the design of a PET scanner presented in [7] at the level of a single detector. A characterization of a CdTe Schottky diode of size 4 mm × 4 mm × 2 mm kept at 5 cm from the radiactive source has been done.…”

Section: Introductionmentioning

confidence: 99%

Energy and coincidence time resolution measurements of CdTe detectors for PET

et al. 2013

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We report on the characterization of 2 mm thick CdTe diode detector with Schottky contacts to be employed in a novel conceptual design of PET scanner. Results at -8 • C with an applied bias voltage of -1000 V/mm show a 1.2% FWHM energy resolution at 511 keV. Coincidence time resolution has been measured by triggering on the preamplifier output signal to improve the timing resolution of the detector. Results at the same bias and temperature conditions show a FWHM of 6 ns with a minimum acceptance energy of 500 keV.These results show that pixelated CdTe Schottky diode is an excellent candidate for the development of next generation nuclear medical imaging devices such as PET, Compton gamma cameras, and especially PET-MRI hybrid systems when used in a magnetic field immune configuration.

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Section: Introductionmentioning

confidence: 99%

Energy and coincidence time resolution measurements of CdTe detectors for PET

et al. 2013

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“…In the framework of the Voxel Imaging PET (VIP) Pathfinder project [18, 19], we propose a novel PEM design based on finely segmented room temperature CdTe detectors to overcome the intrinsic limitations of state-of-the-art commercial PEMs based on scintillating crystals. In this study, the proposed design is simulated and evaluated in terms of sensitivity, spatial resolution, and the minimum detectable tumor size.…”

Section: Introductionmentioning

confidence: 99%

Pixelated CdTe detectors to overcome intrinsic limitations of crystal based positron emission mammographs

et al. 2013

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A positron emission mammograph (PEM) is an organ dedicated positron emission tomography (PET) scanner for breast cancer detection. State-of-the-art PEMs employing scintillating crystals as detection medium can provide metabolic images of the breast with significantly higher sensitivity and specificity with respect to standard whole body PET scanners. Over the past few years, crystal PEMs have dramatically increased their importance in the diagnosis and treatment of early stage breast cancer. Nevertheless, designs based on scintillators are characterized by an intrinsic deficiency of the depth of interaction (DOI) information from relatively thick crystals constraining the size of the smallest detectable tumor. This work shows how to overcome such intrinsic limitation by substituting scintillating crystals with pixelated CdTe detectors. The proposed novel design is developed within the Voxel Imaging PET (VIP) Pathfinder project and evaluated via Monte Carlo simulation. The volumetric spatial resolution of the VIP-PEM is expected to be up to 6 times better than standard commercial devices with a point spread function of 1 mm full width at half maximum (FWHM) in all directions. Pixelated CdTe detectors can also provide an energy resolution as low as 1.5% FWHM at 511 keV for a virtually pure signal with negligible contribution from scattered events.

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“…The Voxel imaging PET (VIP) system is another brain-dedicated system currently under construction, where each detector module consists of 4000 voxel channels. Preliminary simulation studies have been evaluated in [9] [10]. Mitchell, et al evaluated the energy resolution, intrinsic spatial resolution, time resolution, and sensitivity of a prototype PET scanner using strip CdTe detectors by simulation [11].…”

Section: Introductionmentioning

confidence: 99%

Experimental Evaluation of a 3-D CZT Imaging Spectrometer for Potential Use in Compton-Enhanced PET Imaging

Jin

Streicher

Yang

et al. 2023

IEEE Trans. Radiat. Plasma Med. Sci.

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We constructed a prototype positron emission tomography (PET) system and experimentally evaluated large-volume 3-D cadmium zinc telluride (CZT) detectors for potential use in Compton-enhanced PET imaging. The CZT spectrometer offers sub-0.5 mm spatial resolution, an ultrahigh energy resolution (~1% @ 511 keV) and the capability of detecting multiple gamma-ray interactions that simultaneously occurred. The system consists of four CZT detector panels with a detection area of around 4.4 cm × 4.4 cm. The distance between the front surfaces of the two opposite CZT detector panels is ~80 mm. This system allows us to detect coincident annihilation photons and Compton interactions inside the detectors and then exploit Compton kinematics to predict the first Compton interaction site and reject chance coincidences. We have developed a numerical integration technique to model the near-field Compton response that incorporates Doppler broadening, detector's finite resolutions, and the distance between the first and second interactions. This method was used to effectively reject random and scattered coincidence events. In the preliminary imaging studies, we have used point-sources, line-sources, a custom-designed resolution phantom and a commercial image quality (IQ) phantom to demonstrate an imaging resolution of approximately 0.75 mm in PET images, and Compton-based enhancement.

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Simulation of pseudo-clinical conditions and image quality evaluation of PET scanner based on pixelated CdTe detector

Cited by 12 publications

References 4 publications

Energy and coincidence time resolution measurements of CdTe detectors for PET

Energy and coincidence time resolution measurements of CdTe detectors for PET

Pixelated CdTe detectors to overcome intrinsic limitations of crystal based positron emission mammographs

Experimental Evaluation of a 3-D CZT Imaging Spectrometer for Potential Use in Compton-Enhanced PET Imaging

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