Simulation for CZT Compton PET (Maximization of the efficiency for PET using Compton event)

Yoon, Changyeon; Lee, Wonho; Lee, Taewoong

doi:10.1016/j.nima.2011.01.141

Cited by 13 publications

(7 citation statements)

References 2 publications

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“…After performing the simulation, six scenarios using different energy resolution (1%, 4%, and 6% FWHM at 511 keV) and spatial resolution (0.5 × 0.5 × 0.5 mm 3 , 1 × 1 × 1 mm 3 , 1 × 3 × 0.5 mm 3 , 1 × 3 × 1 mm 3 , and 1 × 5 × 1 mm 3 ) were considered based on previous published studies [11], [19], [23]- [25]. Table II summarizes the scenarios considered in post-processing for each system.…”

Section: Methods and Materials A Simulation Setupmentioning

confidence: 99%

“…where A and B are the vectors of the incident and scattered photons, respectively, calculated by the position information of detected events. Yoon et al [19] investigated the angular uncertainty due to effects of Doppler broadening, pixelization effect, and energy broadening with a CZT-based PET system. The energy resolution and spatial resolution of the system was 1% and 1 × 0.5 × 2.5 mm 3 , respectively.…”

Section: Introductionmentioning

confidence: 99%

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Effect of CZT System Characteristics on Compton Scatter Event Recovery

Yang

Reed

et al. 2020

IEEE Trans. Radiat. Plasma Med. Sci.

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Improving 511 keV photon detection sensitivity is a common goal for positron emission tomography (PET) system designers. One attractive approach to increase sensitivity is recovering events that are normally rejected. The kinematics of Compton scattering can be used to recover the line of response through direction difference angle (DDA). The uncertainty of DDA is determined by the energy and spatial resolution of a system. In this paper, we evaluated the performance of small animal cadmium zinc telluride-based PET systems with energy resolution of 1%, 4%, and 6% and different spatial resolution based on prior work for guiding new design efforts. Designs with energy resolution limited by counting statistics and by electronic noise were considered. The influence of modifying the conventional energy window and uncertainty of DDA was investigated. For a system with 4% energy resolution and limited by electronic noise, the figure of merit of noise equivalent count increases by 65% as the lower energy bound increases from 471 to 493 keV. If the system-wide energy resolution becomes worse than 4% of the full width half maximum at 511 keV, going to a pixel size finer than 1 mm has very limited effect in reducing total angular uncertainty. For a system with 1% energy resolution, as the spatial resolution improves from 1 mm to 0.5 mm, the contrast-to-noise ratio increases by 9%.

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Section: Methods and Materials A Simulation Setupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of CZT System Characteristics on Compton Scatter Event Recovery

Yang

Reed

et al. 2020

IEEE Trans. Radiat. Plasma Med. Sci.

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“…17 Another attractive and novel strategy to increase system sensitivity is Compton PET concept, which uses the kinematics of Compton scattering to recover scattered photons concerning the direction of entry of photons. 98,99 Similar to true events, the recovered scattered photons could then be used within the reconstruction process to boost the signal-tonoise ratio further. This could be achieved through CZT detectors with high energy and positioning resolution.…”

Section: Sensitivitymentioning

confidence: 99%

Advances in Preclinical PET Instrumentation

Amirrashedi

Zaidi

2020

PET Clinics

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“…Therefore, we selected only the single-pixel photopeak events of pixelated CdZnTe detectors from the individual CdZnTe pixels. experiments for prototype conventional PET systems using CdZnTe detectors [14,15]. However, few studies have focused on simulating a PET insert system [16].…”

Section: Small-animal Pet Configurations and Monte Carlo Simulationsmentioning

confidence: 99%

“…Monte Carlo (MC) simulation offers a cost-effective and useful method to understand the imaging ability of a PET based on a pixelated CdZnTe detector [13]. Many studies have reported aspects of both simulations and experiments for prototype conventional PET systems using CdZnTe detectors [14,15]. However, few studies have focused on simulating a PET insert system [16].…”

Section: Introductionmentioning

confidence: 99%

A Prototype VP-PET Imaging System Based on Highly Pixelated CdZnTe Detectors

Yin

Wang

et al. 2020

Sensors

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We investigated a prototype virtual-pinhole positron emission tomography (PET) system for small-animal imaging applications. The PET detector modules were made up of 1.3 mm lutetium-yttrium oxyorthosilicate (LYSO) arrays, and the insert detectors consisted of 0.6 mm pixelated cadmium zinc telluride (CdZnTe). To validate the imaging experiment, we did a Monte Carlo simulation for the virtual-pinhole PET (VP-PET) system in the Geant4 Application for Emission Tomography (GATE). For a point source of 22Na with a 0.5 mm diameter, the filtered back-projection algorithm-reconstructed PET image showed a resolution of 0.7 mm full-width-at-half-maximum. The system sensitivity was 0.46 cps/kBq at the center of the field view of the PET system with a source activity of 0.925 MBq and an energy window of 350 to 650 keV. A rod source phantom and a Derenzo phantom with 18F were also simulated to investigate the PET imaging ability. GATE simulation indicated that sources with 0.5 mm diameter could be clearly detected using 0.6 mm pixelated CdZnTe detectors as insert devices in a VP-PET system.

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Simulation for CZT Compton PET (Maximization of the efficiency for PET using Compton event)

Cited by 13 publications

References 2 publications

Effect of CZT System Characteristics on Compton Scatter Event Recovery

Effect of CZT System Characteristics on Compton Scatter Event Recovery

Advances in Preclinical PET Instrumentation

A Prototype VP-PET Imaging System Based on Highly Pixelated CdZnTe Detectors

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