2020
DOI: 10.1016/j.cpet.2020.06.003
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Advances in Preclinical PET Instrumentation

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Cited by 27 publications
(29 citation statements)
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“…Positron emission tomography/SPECT provides quantitative in vivo detection of picomolar concentrations of the target within a large field-of-view ( 26 28 ). The resolution of commercially available microPET is approximately 0.5–2 mm ( 29 32 ), which is sufficient for rat brain imaging but suboptimal for mouse brain imaging considering the spillover and size of the mouse brain (10 mm × 10 mm × 15 mm) ( 33 ). The concept of combining PET/SPECT with CT was first introduced to clinical trials in the early 2000s ( 34 ).…”
Section: Hybrid Imagingmentioning
confidence: 99%
“…Positron emission tomography/SPECT provides quantitative in vivo detection of picomolar concentrations of the target within a large field-of-view ( 26 28 ). The resolution of commercially available microPET is approximately 0.5–2 mm ( 29 32 ), which is sufficient for rat brain imaging but suboptimal for mouse brain imaging considering the spillover and size of the mouse brain (10 mm × 10 mm × 15 mm) ( 33 ). The concept of combining PET/SPECT with CT was first introduced to clinical trials in the early 2000s ( 34 ).…”
Section: Hybrid Imagingmentioning
confidence: 99%
“…However, motion tracking of the rodent head presents more challenges than human head motion tracking. First, the spatial resolution of preclinical scanners is usually better than in clinical scanners, with some modern systems reaching sub-millimetric resolution (54). Therefore, the tracking system should be able to deliver sub-millimetric tracking information.…”
Section: Small Animal Head Motion Trackingmentioning
confidence: 99%
“…Preclinical PET/MRI scanners have reached sub-millimeter resolution, shown in examples [3,[11][12][13][14][15]. A recent summary of design and performance of 38 preclinical systems [11] quotes spatial resolutions between 0.6 mm and 3.0 mm with a median of 1.42 mm [16]. Eight of the systems use Depth Of Interaction (DOI) information.…”
Section: Introductionmentioning
confidence: 99%
“…In particular, we are aiming at a Noise-Equivalent Count Rate (NECR), determined according to NEMA Standards Publication NU 4-2008 (NEMA-NU4) [28], which peaks only far beyond 500 MBq. In [16] peak NECR, values for mouse ranging from 16.9 kcps to 1670 kcps with a median of 204 kcps and for rat ranging from 12.8 kcps to 592.0 kcps with a median of 156 kcps are reported (With varying energy windows and excluding the Mini-EXPLORER [29] and Mini-EXPLORER II [30] NECR data because both systems are targeting primates instead of small rodents). The maxima are reached by the Siemens Inveon stand-alone PET detector with a peak sensitivity of 6.72% [31].…”
Section: Introductionmentioning
confidence: 99%