Automation tools for circuit optimization have proven their usefulness in solving design issues by considering the technological aspects of downscaling. Recent advances have proven that the optimization method based on simulation is a powerful and important solution for the optimal sizing of electronic circuits. In this paper, we propose a simulation-based methodology for automatic optimization of the multi-objective design of an analog/RF circuit. As applications, we use both analog and RF circuits, respectively the LC tank Voltage Controlled Oscillator (VCO) and the new Current-Feedback Operational Amplifier (CFOA). For the LC-VCO, we optimize the power consumption and the phase noise. For the CFOA, we optimize its important performances such as bandwidth and parasitic resistances, for lowvoltage, low-power applications. All simulations are performed by HSPICE using 0.13 μm RF CMOS and 0.18 μm CMOS technologies for the LC-VCO and the CFOA, respectively.