Simulating long-term occupational exposure to decabrominated diphenyl ether using C57BL/6 mice: Biodistribution and pathology

Feng, Yuanming; Hu, Qingliang; Meng, Guang; Wu, Ye; Zeng, Weihong; Zhang, Xing; Yu, Yingxin; Wang, Yan

doi:10.1016/j.chemosphere.2015.01.012

Cited by 18 publications

(13 citation statements)

References 30 publications

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“…An earlier study indicated that BDE 209 exposure could cause irreversible nervous system damage by affecting cholinergic system enzyme activity and inducing lipid peroxidation in adult mice (Liang et al, 2010); hippocampal neuronal damage and degeneration were also observed in adult mice after BDE 209 exposure (Feng et al, 2015). These findings agreed with the potential mechanism underlying the developmental neurotoxicity of PBDEs (Costa et al, 2014) and were also associated with learning and memory (Lu et al, 2014;Jung et al, 2012).…”

Section: Introductionsupporting

confidence: 68%

“…Based on the low absorption rate of BDE 209 through gastrointestinal tract in adult rodents, which was estimated to be approximately only 0.3% of the treated dose (Feng et al, 2015), and the highest serum burden of BDE 209 in workers at an electronic waste dismantling area in Southern China, which was estimated to be 3,436 ng/g (Qu et al, 2007), we designed the exposure dose up to 1,000 mg/kg in the present study. Moreover, the same dose was applied in our previous lab work, and similar doses were also used in other previous studies that treated the adult or pregnant rats/mice with BDE 209 to investigate the thyroid endocrine toxicity, reproductive toxicity, immunotoxicity or developmental neurotoxicity (Biesemeier et al, 2011;Sarkar et al, 2016;Feng et al, 2016).…”

Section: Chemical and Treatmentmentioning

confidence: 99%

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Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats

et al. 2018

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Previous studies have reported the potential developmental neurobehavioral effects of decabrominated diphenyl ethers (BDE 209) on developing animals, but the effects on adult animals are rare or controversial and the mechanism is not fully understood. In the present study, male adult Sprague-Dawley rats performed poor spatial learning and memory in Morris water maze after exposure to BDE 209 by gavage for 30 days. The expression of hippocampal glutamate receptor subunits NR1, NR2B and GluR1, the phosphorylation of NR2B subunit at Ser1301 (p-NR2B Ser1303) and GluR1 subunit at Ser831 (p-GluR1 Ser831) were all decreased, and the phosphorylation ratio of NR2B revealed an increasing trend after BDE 209 exposure. The present study provided evidence that BDE 209 could induce spatial learning and memory deficits in adult rats, and further explored the potential mechanism.

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Section: Introductionsupporting

confidence: 68%

Section: Chemical and Treatmentmentioning

confidence: 99%

Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats

et al. 2018

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“…). Nine months after exposure, no significant difference in the change in BW was observed, which might probably be as a result of the probably increased organ weights in the exposed mice that had been observed in the mice exposed to BDE‐209 for 2 years (Feng et al ., ).…”

Section: Resultsmentioning

confidence: 97%

“…Previously, an experimental animal model was characterized and developed to evaluate the adverse effects of long-term exposure to high levels of BDE-209 (Zeng et al, 2014;Feng et al, 2015). In the present study, this animal model was applied to investigate the potential effects of BDE-209 on the functionalities of CD4 T cells.…”

Section: Introductionmentioning

confidence: 99%

Long‐term exposure to high levels of decabrominated diphenyl ether inhibits CD4 T‐cell functions in C57Bl/6 mice

Feng

Zeng

Wang

et al. 2015

J of Applied Toxicology

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In recent years, the adverse health effects of decabrominated diphenyl ether (BDE-209) have raised more concerns as a growing number of studies reported its persistence in the environment and abundance in the human population, especially in occupational environmental compartments and exposed personnel. This study applies our previous animal model simulating occupational exposure to BDE-209 to investigate its potential adverse effects on CD4 T cells. Female C57Bl/6 mice were orally gavaged with BDE-209 at a dose of 800 mg kg(-1) every 2 days for 10 months and the blood of each mouse was collected for analysis. Kinetic changes of the peripheral immune system were investigated from 1 to 5 months of exposure. The chronic effects on cytokine production, proliferation and the antigen-specific responses of CD4 T cells were evaluated at 7, 9 and 10 months, respectively. The results have shown that impaired proliferation and cytokine (IFN-γ, IL-2 or TNF-α) production of CD4 T cells were observed in BDE-209-exposed mice, accompanied by increased T regulatory cells in the blood. BDE-209 exposure in vitro also suppressed the reactivity of CD4 T cells at concentrations of 0.01, 0.1, 1 and 10 μM. Furthermore, we observed weaker antigen-specific CD4 T-cell responses to Listeria monocytogenes infection in the mice exposed to BDE-209, suggesting decreased resistance to exogenous pathogens. Taken together, these observations indicate an impaired cellular immunity after long-term and relative high-dose exposure to BDE-209 in adult mice. Copyright © 2015 John Wiley & Sons, Ltd.

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“…For the liver, the weight decreased in BDE-209 + dacarbazine group. According to Feng et al (2015), a decrease of liver weight was found in C57BL/6 mice after exposure to higher dose of BDE-209 (1000x) for two years. This suggests that even low doses BDE-209, such as those tested in here, may be harmful, which was con rmed by the increased ALT activity in the blood.…”

Section: ) Discussionmentioning

confidence: 99%

BDE-209 Becreases the Efficacy of Dacarbazine Treatment for Melanoma in C57BL/6 Mice

Manuitt-Brito

Souza

Neto

et al. 2021

Preprint

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Humans are widely exposed to environmental chemical toxicants potentially related to disease susceptibility. Polybrominated diphenyl ethers (PBDEs) present a proven risk associated with cancer, but no studies are related with the tumor progression. The decabromodiphenyl ether (BDE-209) is a flame-retardant detected in human plasma, breast milk and umbilical cord. Melanoma is a skin cancer with high metastatic potential and poor response to therapies. The use of alkylating agents such as dacarbazine is still a common protocol for the treatment of melanoma, mainly in Brazilian Public Health Care System. Recently, we reported the role of BDE-209 on the incidence of melanoma metastasis in different organs of mice after inoculation of B16-F10 cells. In the current study, we describe the effects of BDE-209 on dacarbazine treatment for melanoma. Adult male and female C57BL6 mice were exposed to BDE-209 for 45 days, inoculated with B16-F10 cells and treated with dacarbazine for 21 days (five doses of 40 mg.kg− 1). At 66th day, the animals were euthanized, and the blood, lung, liver, kidney and brain were sampled for hematological, biochemical and metastasis counting analyses. The results showed a decrease of lung metastases in animals treated with dacarbazine and a significant increase in mice previously exposed to BDE-209. Foremost, BDE-209 impaired dacarbazine treatment. These findings demonstrate the effect of BDE-209 and the decreased efficacy of dacarbazine treatment, favoring cancer progression and affecting the disease prognosis.

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Simulating long-term occupational exposure to decabrominated diphenyl ether using C57BL/6 mice: Biodistribution and pathology

Cited by 18 publications

References 30 publications

Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats

Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats

Long‐term exposure to high levels of decabrominated diphenyl ether inhibits CD4 T‐cell functions in C57Bl/6 mice

BDE-209 Becreases the Efficacy of Dacarbazine Treatment for Melanoma in C57BL/6 Mice

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