Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats

Xiong, Li; Hao, Liyue; Zeng, Fancai; Maoting, Li; Li, Ya; He, Ting; Yang, Zhigang; Zhu, Shunyi; Wenwen, Gu; Yan, Tao

doi:10.2131/jts.43.645

Cited by 8 publications

(12 citation statements)

References 47 publications

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“…The MWM detects spatial acquisition and memory participated in the hippocampus, but it is also a passive escape experiment forcing animals to swim continuously so that the animals cannot show the autonomous exploration behavior . Therefore, we also conducted a novel object recognition experiment, which can test the recognition ability of mice for novel objects and the memory retention ability of familiar objects. , Some studies had confirmed that BDE-209 can alter the neurobehavior. , For example, male adult Sprague-Dawley rats performed poor spatial learning and memory in MWM after oral exposure to BDE 209 for 30 days . The neurobehavioral effects of HBCD had also been reported, whereas the neurobehavioral effects of TBBPA were unequivocal.…”

Section: Discussionmentioning

confidence: 99%

“…20,21 Some studies had confirmed that BDE-209 can alter the neurobehavior. 22,23 For example, male adult Sprague-Dawley rats performed poor spatial learning and memory in MWM after oral exposure to BDE 209 for 30 days. 23 The neurobehavioral effects of HBCD had also been reported, 24 whereas the neurobehavioral effects of TBBPA were unequivocal.…”

Section: ■ Discussionmentioning

confidence: 99%

“…22,23 For example, male adult Sprague-Dawley rats performed poor spatial learning and memory in MWM after oral exposure to BDE 209 for 30 days. 23 The neurobehavioral effects of HBCD had also been reported, 24 whereas the neurobehavioral effects of TBBPA were unequivocal. Kacew and Hayes (2020) suggest that TBBPA did not appear to target the brain and was not considered as a neurotoxicant.…”

Section: ■ Discussionmentioning

confidence: 99%

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Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice

Wang

Dai

2022

Chem. Res. Toxicol.

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Brominated flame retardants (BFRs) are ubiquitous industrial chemicals. In China, BFRs that are applied in large quantities include decabromodiphenyl ether (BDE-209), tetrabromobisphenol A (TBBPA), and hexabromocyclododecane (HBCD). Although findings are not always unequivocal, mounting evidence in vivo suggests that the BFRs have potential neurotoxicity. The present study aimed to assess and compare the neurotoxic effects of these three BFRs’ exposure. Male mice were orally exposed to BDE-209, TBBPA, or HBCD at 50 and 100 mg/kg bw/day for 28 days. The cognitive behavior, oxidative stress (ROS, MDA, and GSH), apoptosis-related genes (caspase-3, bax, and bcl-2), memory-related proteins (BDNF and PSD-95), and neurotransmitters (AChE and ChAT) were detected comparatively. Results showed that high doses of BDE-209, TBBPA, and HBCD exposure impaired spatial memory of mice, elevated ROS and MDA and reduced GSH levels of hippocampus, upregulated caspase-3 and bax expressions, decreased BDNF and PSD-95 levels, and disordered AChE and ChAT levels. Notably, BDE-209 caused greater adverse effects > HBCD > TBBPA. This study confirms and extends that these three BFRs had similar neurotoxic effects at current concentrations, although they may be more or less toxic.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

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Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice

Wang

Dai

2022

Chem. Res. Toxicol.

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“…For the research of metal semioxide semiconductor materials, there have been research directions for related content as early as before. It was discovered that titanium dioxide can catalyze the start of hydrogen production under the action of sunlight [13]. The photocatalysis of metal oxide semiconductor materials has been rapidly developed.…”

Section: Polybrominated Diphenyl Ethers Based On Metal Oxidesmentioning

confidence: 99%

Application of Metal Oxides Prepared Based on Ferroelectric‐Based Photoelectric Conversion Materials in the Thermal Degradation of Polybrominated Diphenyl Ethers

Gao

Huo

et al. 2022

Journal of Nanomaterials

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In today’s environment where the society attaches great importance to environmental pollution, there has been a certain amount of research at home and abroad to explore the solutions to pollution of the large amount of polluting and persistent harmful substances that remain in nature. And most people think that it is necessary to solve the problem of pollution in two ways. (1) Energy: without discussing other energy sources, we will only discuss the main oil of today’s energy. The treatment and use of this energy will cause pollution to a certain degree, and it has been overexploited. The exploration of new energy sources and increasing the use of natural energy such as wind and solar energy are the main research directions today. (2) Degradation of existing pollutants: nowadays, due to the rapid development of various industries, attention to environmental pollution has reached a point that cannot be ignored. As a kind of brominated flame retardant, polybrominated diphenyl ethers are widely used because of their low price and stable chemical properties, mostly in electronic appliances, building materials, textiles, furniture, and other products. But the substance is extremely harmful. This article focuses on the degradation treatment of tetrabromodiphenyl ether, which is one of the polybrominated diphenyl ethers that are long-lasting and difficult to be degraded in the environment. It has become an emerging persistent organic pollutant due to its toxicity, persistence, and bioaccumulation. Based on the reduction and debromination of zero-valent iron, the effect of debromination of tetrabromodiphenyl ether is explored under the coupling effect of the nanosized iron powder with the smaller particles of zero-valent iron and vitamin B12. The experimental results in this paper show that when the dosage of nanoiron powder is between 0.0 g/L and 0.15 g/L, according to the degradation diagram, the reaction rate is continuously strengthened with the increase of nanoiron powder. When the dosage of nanoiron powder is 0.15 g/L-1.0 g/L, the effect will be weakened with the increase of the concentration. Therefore, an increase in the concentration of nanoiron powder will promote the progress of the debromination reaction. But when it reaches a certain level, the reaction rate will gradually decrease until it stops.

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“…However, the outstanding question in the eld remains which molecular changes induced by PBDE-209 underlie this cognitive impairment. PBDE-209 alters neurotransmitter systems, including the glutamatergic system, in mice, culminating in neuronal damage and degeneration in brain regions (Johansson et al 2008;Xiong et al 2018). The Nmethyl-D-aspartate receptor (NMDAR), an ionotropic glutamate receptor, regulates long-term potentiation (LTP) and is, therefore, an important component in the processes of learning and memory.…”

Section: Introductionmentioning

confidence: 99%

Differential binding of CREB and REST/NRSF to NMDAR1 promoter is associated with the sex-selective cognitive deficit following postnatal PBDE-209 exposure in mice

Gupta

Gandhi

et al. 2023

Environ Sci Pollut Res

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Neonatal exposure to decabromodiphenyl ether (PBDE-209), a ubiquitous environmental pollutant, affects cognitive performances in the later stage of life in a sex-dependent manner. PBDE-209 interferes with glutamatergic signaling and N-methyl-D-aspartate receptor (NMDAR) subunits with unresolved regulatory mechanisms. This study exposed male and female mice pups through postnatal day (PND) 3-10 to PBDE-209 (oral dose: 0, 6, or 20 mg/kg body weight). The frontal cortex and hippocampus, collected from neonate (PND 11) and young (PND 60) mice, were analyzed for cAMP response elementbinding protein (CREB) and RE1-silencing transcription factor/ Neuron-restrictive silencer factor (REST/NRSF) binding to NMDAR1 promoter and expression of NMDAR1 gene by electrophoretic mobility shift assay and semi-quantitative RT-PCR respectively. Behavioral changes were assessed using spontaneous alternation behavior and novel object recognition tests in young mice. In neonates, the binding of CREB was increased, while REST/NRSF was decreased signi cantly to their cognate NMDAR1 promoter sequences at the high dose of PBDE-209 in both the sexes. This reciprocal pattern of CREB and REST/NRSF interactions correlates with the up-regulation of NMDAR1 expression. Young males followed a similar pattern of CREB and REST/NRSF binding and NMDAR1 expression as in neonates. Surprisingly, young females did not show any alteration when compared to age-matched controls. Also, we found that only young males showed working and recognition memory de cits. These results indicate that early exposure to PBDE-209 interferes with CREB-and REST/NRSF-dependent regulation of the NMDAR1 gene in an acute setting. However, long-term effects persist only in young males that could be associated with cognitive impairment.

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Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats

Cited by 8 publications

References 47 publications

Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice

Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice

Application of Metal Oxides Prepared Based on Ferroelectric‐Based Photoelectric Conversion Materials in the Thermal Degradation of Polybrominated Diphenyl Ethers

Differential binding of CREB and REST/NRSF to NMDAR1 promoter is associated with the sex-selective cognitive deficit following postnatal PBDE-209 exposure in mice

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