Simulating image-guided in situ bioprinting of a skin graft onto a phantom burn wound bed

Ding, Houzhu; Chang, Robert C.

doi:10.1016/j.addma.2018.06.022

Cited by 23 publications

(35 citation statements)

References 25 publications

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“…Ionic crosslinked bioink has also been combined with a thermo-sensitive bioink. For example, a mixed hydrogel composed of gelatin and alginate was casted around the wound mold with Ca 2+ ionic and placed in 4 °C for gelation ( Figure 6 E) before printing a skin graft on the burn wound bed by in situ bioprinting [ 27 ].…”

Section: Current Bioink Products For Skin Bioprintingmentioning

confidence: 99%

“…( E ) Cast pure gelation and red gelatin placed in 4 °C for gelation. Reproduced with permission from [ 27 ]; copyright Elsevier, 2018.…”

Section: Figurementioning

confidence: 99%

“…Acellular bioink is mainly composed of biomaterials, while cell-encapsulating bioink also includes living cells and signaling molecules like growth factors [ 19 ]. Currently, hydrogel materials (e.g., collagen, gelatin and alginate) are widely used as bioinks in bioprinting skin systems owing to their capacity to encapsulate cells and printability [ 25 , 26 , 27 , 28 , 29 ]. Specifically, collagen hydrogel is commonly utilized for skin repair, because collagen is the most abundant protein-based natural polymer in skin tissue and is a main component of the native extracellular matrix (ECM), which means it is capable of providing a favorable microenvironment [ 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting

Zheng

et al. 2020

Polymers

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The skin plays an important role in protecting the human body, and wound healing must be set in motion immediately following injury or trauma to restore the normal structure and function of skin. The extracellular matrix component of the skin mainly consists of collagen, glycosaminoglycan (GAG), elastin and hyaluronic acid (HA). Recently, natural collagen, polysaccharide and their derivatives such as collagen, gelatin, alginate, chitosan and pectin have been selected as the matrix materials of bioink to construct a functional artificial skin due to their biocompatible and biodegradable properties by 3D bioprinting, which is a revolutionary technology with the potential to transform both research and medical therapeutics. In this review, we outline the current skin bioprinting technologies and the bioink components for skin bioprinting. We also summarize the bioink products practiced in research recently and current challenges to guide future research to develop in a promising direction. While there are challenges regarding currently available skin bioprinting, addressing these issues will facilitate the rapid advancement of 3D skin bioprinting and its ability to mimic the native anatomy and physiology of skin and surrounding tissues in the future.

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Section: Current Bioink Products For Skin Bioprintingmentioning

confidence: 99%

“…( E ) Cast pure gelation and red gelatin placed in 4 °C for gelation. Reproduced with permission from [ 27 ]; copyright Elsevier, 2018.…”

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting

Zheng

et al. 2020

Polymers

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“…Recently, Ding and Chang (2018) developed a novel in situ bioprinting workflow that integrates imaging of burn wounds with additive manufacturing to reduce the time of medical intervention and improving the efficacy of wound healing. The rapid production of patient-specific skin graft intend to eliminate the demand for the in vitro fabrication and culture of cell-laden tissue construct in a laboratory setting (Ding and Chang, 2018).…”

Section: D In Situ Bioprintingmentioning

confidence: 99%

In situ Enabling Approaches for Tissue Regeneration: Current Challenges and New Developments

Dias

Ribeiro

Baptista-Silva

et al. 2020

Front. Bioeng. Biotechnol.

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“…Among the estimated 265,000 deaths per year caused by burns, many people lost skin function and had wound infection leading to multi-organ failure [188]. Engineered skin tissue constructs showed potential for artificial skin replacement [24,189]. Cell-laden alginate hydrogel blended with other biomaterials was added to a 3D bioprinter to fabricate bioactive skin scaffolds.…”

Section: 3d Bioprinting Applications Based On Marine-derived Bioinksmentioning

confidence: 99%

Biomaterials Based on Marine Resources for 3D Bioprinting Applications

et al. 2019

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Three-dimensional (3D) bioprinting has become a flexible tool in regenerative medicine with potential for various applications. Further development of the new 3D bioprinting field lies in suitable bioink materials with satisfied printability, mechanical integrity, and biocompatibility. Natural polymers from marine resources have been attracting increasing attention in recent years, as they are biologically active and abundant when comparing to polymers from other resources. This review focuses on research and applications of marine biomaterials for 3D bioprinting. Special attention is paid to the mechanisms, material requirements, and applications of commonly used 3D bioprinting technologies based on marine-derived resources. Commonly used marine materials for 3D bioprinting including alginate, carrageenan, chitosan, hyaluronic acid, collagen, and gelatin are also discussed, especially in regards to their advantages and applications.

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Simulating image-guided in situ bioprinting of a skin graft onto a phantom burn wound bed

Cited by 23 publications

References 25 publications

Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting

Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting

In situ Enabling Approaches for Tissue Regeneration: Current Challenges and New Developments

Biomaterials Based on Marine Resources for 3D Bioprinting Applications

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