Simulating electrical properties of interdigitated electrode designs for impedance-based biosensing applications

Abstract

In this paper, we describe a point-of-care biosensor design. The uniqueness of our design is in its capability for detecting a wide variety of target biomolecules and the simplicity of nanoparticle enhanced electrical detection. The electrical properties of interdigitated electrodes and the mechanism for gold nanoparticle-enhanced impedance-based biosensor systems based on these electrodes were simulated using COMSOL Multiphysics software. Understanding these properties and how they can be affected by the design of the sensor, environment during detection, and target biomolecules is vital in designing effective biosensor devices. Simulations were used to show electrical screening for interdigitated electrodes in a salt solution as well as the electric field between individual digits of electrodes. Using these simulations, it was observed that gold nanoparticles bound closely to interdigitated electrodes can lower the electric field magnitude between the digits of the electrode.

Optimal interdigitated electrode sensor design for biosensors using multi-objective particle-swarm optimization

“…The simple capacitive coupling between the two electrodes is what is meant by the capacitance that mimics the dielectric portion of the medium under test. The dielectric permittivity and this capacitance are connected by (7).…”

“…Non-ionizing radiation interactions with biological matter are progressing in diagnostic and therapeutic issues. The electromagnetic properties of the propagation medium must be determined in order to make progress [7]. Another application aspect that requires the values of electrical characteristics such as conductivity and permittivity of biological tissues is public health problems related to electromagnetic fields (dosimetry, biological impacts).…”

Micro and Nano Interdigitated Electrode Array (IDEA)-Based MEMS/NEMS as Electrochemical Transducers: A Review

“…Interestingly, a preliminary study on the electric double layer (EDL), electric field distribution, and current density of IDEA can be performed numerically using finite element analysis (FEA) [ 88 ] software, such as COMSOL Multiphysics and ELECTRO. Finite element analysis simulation gives an early insight into the experimental outcomes and minimizes design errors [ 89 , 90 , 91 , 92 ]. The digital simulation helps researchers to predict the IDEA’s electrical performance by virtually varying the height, gap, and width of IDEA [ 46 , 48 , 69 , 93 , 94 , 95 ].…”