Simulated tissue growth in tetragonal lattices with mechanical stiffness tuned for bone tissue engineering

Design and mechanical properties analysis of heterogeneous porous scaffolds based on bone slice images

“…The porous scaffolds constructed by the above methods are uniform porous scaffolds with periodic pore distribution, and their internal pore structure characteristics are quite different from those of natural bone, which is not conducive to the reconstruction of bone tissue. [16][17][18][19] With the development of computers and the application of image processing algorithms in biomedical engineering, the design of HPS with pore structure characteristics closer to natural bone has attracted the attention of many scholars. Ramin et al 20 proposed a secondary development algorithm based on Catia to design HPS.…”

“…Yoo 15 meshed the solid model with hexahedral elements in the finite‐element algorithm, and then used the shape function method to map the TPMS elements to the divided hexahedral elements to generate porous scaffolds. The porous scaffolds constructed by the above methods are uniform porous scaffolds with periodic pore distribution, and their internal pore structure characteristics are quite different from those of natural bone, which is not conducive to the reconstruction of bone tissue 16–19 …”

Orthopedic Scaffolds: Evaluation of Structural Strength and Permeability of Fluid Flow via an Open Cell Neovius Structure for Bone Tissue Engineering

“…Bone is a complex tissue that is constantly undergoing dynamic biological remodeling, a linked process in which osteoclasts resorb old or damaged bone tissue and osteoblasts produce new bone to preserve homeostasis . The mechanical environment and the interstitial fluid flow can have a significant impact on bone tissue remodeling. , Vascularization and osteogenic cell proliferation are essential components of osteogenesis and are aided in bone repair by interstitial fluid flow in the periosteum and surrounding tissues. , Johnson et al proposed that fluid flow-induced shear in bone governs the constant and rapid release of nitric oxide from osteoblasts and that fluid flow-induced vascularization may accelerate bone growth. Meanwhile, mechanical loading causes bone deformation, which causes interstitial fluid flow in the bone tissue .…”

“…Generally, bone responds to mechanical stimuli through apposition under heavy loading and resorption during disuse . Wolff’s law, Perren’s strain theory, and various tests help us to verify the effect of mechanical stresses and strain on bone adaptation. , …”

“…1 The mechanical environment and the interstitial fluid flow can have a significant impact on bone tissue remodeling. 2,3 Vascularization and osteogenic cell proliferation are essential components of osteogenesis and are aided in bone repair by interstitial fluid flow in the periosteum and surrounding tissues. 4,5 Johnson et al proposed that fluid flow-induced shear in bone governs the constant and rapid release of nitric oxide from osteoblasts and that fluid flow-induced vascularization may accelerate bone growth.…”