Simulated migrating motor complex and its impact on the release properties of hydrophilic matrix systems

Mechanistic study of model drug release from HPMC matrices in fed gastric media

“…In the present study, we employ a biorelevant in vitro dissolution model, the advanced gastric simulator (AGS) [31,40] to study the effect of fed conditions combined with strong mechanical stresses on the BCS class I model drug (paracetamol) release form the HPMC matrix tablets. The AGS has been shown to successfully recreate the motility patterns, closely resembling the in vivo gastric dynamics [41]. With the present study, we intend to show also its applicability to better predict the food effects on the release kinetics from HPMC MR formulations compared to the conventional dissolution methods.…”

“…H. Vrbanac et al measured using the SmartPill® capsule in our previous research [41]. The average pressure, generated by the simultaneous closing and opening of the constriction mechanisms of the program, was 130 ± 19 mbar, with the maximum pressure peak of 451 mbar.…”

“…The main components of the apparatus are mechatronic constriction mechanisms, circularly fitted to a flexible vessel, a "pyloric" valve at the vessel outlet, temperature controlled chamber (37 ± 0.5 • C) and custom made computer software. The detail description of the apparatus is featured in our previous publications [31,40,41,44]. The dissolution testing in AGS was performed in 250 mL of preheated dissolution media (37 ± 0.5 • C) presented in Table 2.…”

Gastro-retentive drug delivery technologies and their applications with cardiovascular medications

“…The fundus and body are mostly employed to hold undigested food, while the antrum works like a pump, assisting stomach emptying through pushing action [26]. The migrating myoelectric complex (MMC) is the pattern of stomach motility [27]; several stages of the MMC are depicted in (Fig. 3).…”