Mechanistic study of model drug release from HPMC matrices in fed gastric media

Vrbanac, Helena; Trontelj, Jurij; Kalčič, Špela; Legen, Igor

doi:10.1016/j.jddst.2020.102034

Cited by 3 publications

(3 citation statements)

References 52 publications

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“…In conclusion, despite some limitations, the benefits of biodegradable stents generally outweigh the disadvantages, and the therapeutic application of biodegradable gastric stents is a growing trend. In the future, it may be possible to combine different drug-carrying materials to design reservoirs that can accommodate large doses of drugs and improve drug delivery design [7].…”

Section: Gastric Stentsmentioning

confidence: 99%

Advancement on Digestive Tract Biomedical Stents, A Review

Sun,

Wang,

et al. 2023

JFBI

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Biomedical stents for the digestive tract address many of the limitations associated with traditional surgical treatments for gastrointestinal diseases. This paper provides a review of the performance requirements, complications, and limitations of stent materials in the treatment of common digestive tract diseases. The advantages and disadvantages of different materials and processing technologies for digestive tract stents are discussed. Furthermore, considering the diverse requirements for ideal alimentary canal stent materials, the challenges that require further research are outlined in detail, providing strategic references for the development of biomedical stents for the digestive tract.

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Section: Gastric Stentsmentioning

confidence: 99%

Advancement on Digestive Tract Biomedical Stents, A Review

Sun,

Wang,

et al. 2023

JFBI

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“…The bioadhesive property of HPMC has been attributed to the presence of abundant -OH functional groups in the molecule that can form hydrogen bonds with water and other HPMC molecules [ 21 ] ( Figure 1 A). Additionally, HPMC has a minimal interaction with drugs (other than H-bonding interactions) and has demonstrated the ability to improve bioadhesion and enhance local delivery of drugs through improved retention [ 22 , 23 ]. Polyvinylpyrrolidone (PVP), a hydrophilic synthetic polymer, is commonly used in controlled-drug-delivery systems due to its biocompatibility [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Hydroxypropyl Methylcellulose Bioadhesive Hydrogels for Topical Application and Sustained Drug Release: The Effect of Polyvinylpyrrolidone on the Physicomechanical Properties of Hydrogel

Pan,

Svirskis,

Waterhouse

et al. 2023

Pharmaceutics

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Hydrogels are homogeneous three-dimensional polymeric networks capable of holding large amounts of water and are widely used in topical formulations. Herein, the physicomechanical, rheological, bioadhesive, and drug-release properties of hydrogels containing hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) were examined, and the intermolecular interactions between the polymers were explored. A three-level factorial design was used to form HPMC–PVP binary hydrogels. The physicomechanical properties of the binary hydrogels alongside the homopolymeric HPMC hydrogels were characterized using a texture analyzer. Rheological properties of the gels were studied using a cone and plate rheometer. The bioadhesiveness of selected binary hydrogels was tested on porcine skin. Hydrophilic benzophenone-4 was loaded into both homopolymeric and binary gels, and drug-release profiles were investigated over 24 h at 33 °C. Fourier transform infrared spectroscopy (FTIR) was used to understand the inter-molecular drug–gel interactions. Factorial design analysis supported the dominant role of the HPMC in determining the gel properties, rather than the PVP, with the effect of both polymer concentrations being non-linear. The addition of PVP to the HPMC gels improved adhesiveness without significantly affecting other properties such as hardness, shear-thinning feature, and viscosity, thereby improving bioadhesiveness for sustained skin retention without negatively impacting cosmetic acceptability or ease of use. The release of benzophenone-4 in the HPMC hydrogels followed zero-order kinetics, with benzophenone-4 release being significantly retarded by the presence of PVP, likely due to intermolecular interactions between the drug and the PVP polymer, as confirmed by the FTIR. The HPMC–PVP binary hydrogels demonstrate strong bioadhesiveness resulting from the addition of PVP with desirable shear-thinning properties that allow the formulation to have extended skin-retention times. The developed HPMC–PVP binary hydrogel is a promising sustained-release platform for topical drug delivery.

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“…So far, synthetic and natural polymers such as hydroxypropyl cellulose, poly vinylpyrrolidone, poly(vinyl alcohol), , sodium alginate, xanthan gum, locust bean gum, and guar gum have been utilized as release controlling materials. Among the various hydrophilic polymers, hydroxypropylmethylcellulose (HPMC) is widely used polymer due to its safety, applicability, and compatibility with many drugs. ,− …”

Section: Introductionmentioning

confidence: 99%

Drug Extended-Release System Utilizing Micelle Formation of Highly Water-Soluble Drugs and a Counter Polymer

Kojima,

Yoshida,

Kondo

et al. 2023

Mol. Pharmaceutics

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The objective of this study is to clarify the mechanism of extending release of highly water-soluble drugs via counter polymer (CP) utilization in poly(ethylene oxide) (PEO)/polyethylene glycol (PEG) matrix tablets. Carbomer, poly(acrylic acid), was used as a CP, which has the opposite charges to the drugs. The in vitro release of several highly water-soluble drugs from PEO/PEG tablet with or without CP were tested, the relationship between the sustained release effect by a CP (SRE) and the physicochemical properties of the drugs was investigated. The results demonstrated that the utilization of CP can extend the release of some highly water-soluble drugs by effectively controlling the drug diffusion through matrices. On the other hand, the effectiveness of CP was different depending on the drugs applied. There were not statistical correlations between SRE and physicochemical properties such as solubility, molecular weight, and charge intensity of the drugs, while a micelle forming property of the drugs played an important role in SRE by CP. It was concluded that CP, Carbomer, having negative charges could effectively interact with opposite charges on the surface of stable drug micelles, which could result in a significant decrease in drug diffusion leading to extended drug release. It is considered that the system utilizing CP is a promising approach to achieve extended release of highly water-soluble drugs with a reasonable tablet size, especially in the case of large drug loading.

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Mechanistic study of model drug release from HPMC matrices in fed gastric media

Cited by 3 publications

References 52 publications

Advancement on Digestive Tract Biomedical Stents, A Review

Advancement on Digestive Tract Biomedical Stents, A Review

Hydroxypropyl Methylcellulose Bioadhesive Hydrogels for Topical Application and Sustained Drug Release: The Effect of Polyvinylpyrrolidone on the Physicomechanical Properties of Hydrogel

Drug Extended-Release System Utilizing Micelle Formation of Highly Water-Soluble Drugs and a Counter Polymer

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