Simply put: Vaccination saves lives

Orenstein, Walter A.; Ahmed, Rafi

doi:10.1073/pnas.1704507114

Cited by 250 publications

(208 citation statements)

References 14 publications

(9 reference statements)

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“…In addition to preventing deaths, vaccines prevent disease and disability, including in adults and the elderly. In a high-income country such as the United States, for a single birth cohort, vaccines prevent nearly 20 million cases of disease, and more than 40,000 deaths 8 .…”

Section: How Immunization Has Crucially Benefited Societymentioning

confidence: 99%

Immunization: vital progress, unfinished agenda

Piot

Larson

O’Brien

et al. 2019

Nature

137

127

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Section: How Immunization Has Crucially Benefited Societymentioning

confidence: 99%

Immunization: vital progress, unfinished agenda

Piot

Larson

O’Brien

et al. 2019

Nature

137

127

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“…Vaccines are considered one of the most important medical advances in the history of humanity, preventing and eradicating diseases [1,2]. The World Health Organization (WHO) estimates that vaccines save around 2-3 million lives a year [3].…”

Section: Introductionmentioning

confidence: 99%

A self-aggregating peptide: implications for the development of thermostable vaccine candidates

et al. 2020

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Background: The use of biomaterials has been expanded to improve the characteristics of vaccines. Recently we have identified that the peptide PH (1-110) from polyhedrin self-aggregates and incorporates foreign proteins to form particles. We have proposed that this peptide can be used as an antigen carrying system for vaccines. However, the immune response generated by the antigen fused to the peptide has not been fully characterized. In addition, the adjuvant effect and thermostability of the particles has not been evaluated.Results: In the present study we demonstrate the use of a system developed to generate nano and microparticles carrying as a fusion protein peptides or proteins of interest to be used as vaccines. These particles are purified easily by centrifugation. Immunization of animals with the particles in the absence of adjuvant result in a robust and long-lasting immune response. Proteins contained inside the particles are maintained for over 1 year at ambient temperature, preserving their immunological properties. Conclusion:The rapid and efficient production of the particles in addition to the robust immune response they generate position this system as an excellent method for the rapid response against emerging diseases. The thermostability conferred by the particle system facilitates the distribution of the vaccines in developing countries or areas with no electricity.

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“…Благодаря ежегодным программам по иммунизации удается сохранить до 6 млн детских жизней во всем мире, а также предотвратить многие случаи инвалидиза-ции вследствие осложнений инфекционных заболеваний [9,10]. Удалось победить такие болезни, как натуральная оспа (последний эпизод диагностирован 35 лет назад), и значительно сократить заболеваемость другими вак-циноуправляемыми инфекциями.…”

Section: заключениеunclassified

“…По данным Роспотребнадзора, с начала 2017 г. эпидемия кори заре-гистрирована в 14 странах Европы (при этом подавляю-щее количество летальных исходов -31 -зарегистри-ровано в Румынии) [6,10].…”

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Overcoming ‘Anti-Vaccination Scepticism’: Seeking a Solution to the Situation

et al. 2018

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Обоснование. Проблема недоверия к иммунизации широко распространена не только в РоссииКонтактная информация: Калюжная Татьяна Анатольевна, кандидат медицинских наук, врач-педиатр отделения вакцинопрофилактики детей с отклонениями в состоянии здоровья консультативно-диагностического центра ФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава РФ

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Simply put: Vaccination saves lives

Cited by 250 publications

References 14 publications

Immunization: vital progress, unfinished agenda

Immunization: vital progress, unfinished agenda

A self-aggregating peptide: implications for the development of thermostable vaccine candidates

Overcoming ‘Anti-Vaccination Scepticism’: Seeking a Solution to the Situation

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