Simplified treatment planning for interstitial laser thermotherapy by disregarding light transport: A numerical study

Olsrud, Johan; Wirestam, Ronnie; Persson, Bertil; Tranberg, Karl‐Göran

doi:10.1002/(sici)1096-9101(1999)25:4<304::aid-lsm5>3.0.co;2-u

Cited by 11 publications

(4 citation statements)

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“…One advantage of using laser technology is that there are sophisticated systems for controlling ablative lesion characteristics and size using feedback systems, and dose-planning systems are available with laser technology [39, 42, 52–54]. An important practical advantage over other thermal sources is that the thin and flexible laser fibers make it possible to reach tumors more easily and safely [55].…”

Section: General Principles and Techniquesmentioning

confidence: 99%

Laser Ablation for Small Hepatocellular Carcinoma

Pacella

Francica²,

Costanzo

2011

Radiology Research and Practice

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Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and is increasingly detected at small size (<5 cm) owing to surveillance programmes in high-risk patients. For these cases, curative therapies such as resection, liver transplantation, or percutaneous ablation have been proposed. When surgical options are precluded, image-guided tumor ablation is recommended as the most appropriate therapeutic choice in terms of tumor local control, safety, and improvement in survival. Laser ablation (LA) represents one of currently available loco-ablative techniques: light is delivered via flexible quartz fibers of diameter from 300 to 600 μm inserted into tumor lesion through either fine needles (21g Chiba needles) or large-bore catheters. The thermal destruction of tissue is achieved through conversion of absorbed light (usually infrared) into heat. A range of different imaging modalities have been used to guide percutaneous laser ablation, but ultrasound and magnetic resonance imaging are most widely employed, according to local experience and resource availability. Available clinical data suggest that LA is highly effective in terms of tumoricidal capability with an excellent safety profile; the best results in terms of long-term survival are obtained in early HCC so that LA can be proposed not only in unresectable cases but, not differently from radiofrequency ablation, also as the first-line treatment.

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Section: General Principles and Techniquesmentioning

confidence: 99%

Laser Ablation for Small Hepatocellular Carcinoma

Pacella

Francica²,

Costanzo

2011

Radiology Research and Practice

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“…This simplification is one of the main reasons why other researchers used Pennes' theory for modelling heat transfer in living tissues for decades. [4][5][6] He assumed heat transfer occurs only between arteriole and tissue and ignored the effects of the vein-artery network and blood velocity change in the artery. However, some researchers proposed other heat source terms.…”

Section: Introductionmentioning

confidence: 99%

Treatment Modelling of a 3D Tumour in Brain by Laser-Induced Interstitial Thermotherapy

Amini,

Ahmadikia

2023

J Lasers Med Sci

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Introduction: There are some ways to examine heat transfer in tumor tissue, which is an important issue in bioengineering. One of these ways uses the bioheat equation, proposed by Pennes, in a continuous medium. Another one uses a porous medium to model heat transfer in living tissues. The objective of this paper was to study an approach to modelling the temperature distribution and tumour ablation in brain tissue and compare results to Pennes’ approach. Methods: This approach presents and uses a porous medium as the tissue instead of a continuous medium. In addition, the two approaches (simulation in continuous and porous medium) are compared in terms of temperature simulation and amount of cell ablation. The density, heat conduction factor, and blood perfusion rate are considered functions of temperature. Results: In these approaches, after an 85-second treatment, the temperature increases to about 90°C. The temperature increase of the porous medium is relatively the same as that of the continuous medium and for this reason, the amount of cancerous cells that are ablated in a porous medium is approximately the same as that in a continuous medium. The volume of cell ablation is about 6500 mm3 for two ideas. In addition, the degree of damage, computed from the Arrhenius integral method, and the ablated volume of the tumour endorse equality at the end of treatment. According to the results, similar to the continuous approach, the porous approach predicts the temperature and amount of volume of damaged cells. Conclusion: Therefore, it is possible to use the porous approach instead of the Pennes approach for tumour treatment.

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“…Numerous studies have discussed treatment planning models designed to predict the tissue response to laser irradiation [10][11][12][13][14][15][16][17][18][19]. However, we developed the first treatment planning model to permit prediction of HSP expression in addition to the temperature and injury fraction (defined in Eq.…”

Section: Introductionmentioning

confidence: 99%