Simple underlay myringoplasty

Sakagami, Masafumi; Yuasa, Ryo; Yuasa, Yu

doi:10.1017/s0022215106005561

Cited by 42 publications

(36 citation statements)

References 7 publications

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“…Multiple substances have been used as a scaffold in the treatment of TM perforation such as temporalis muscle fascia, perichondrium, cartilage, fat, and spongostan (haemostatic gel foam). Although the rates of closures after the initial attempt are not bad (2), there is a continuous search for new materials that are more effective in the healing of these TM perforations. Among these, the amniotic membrane could be of interest since it contains stem cells which are endowed with anti-inflammatory, anti-infective and immuno-modulatory properties (3).…”

Section: Introductionmentioning

confidence: 99%

Chronification of Tympanic Perforation with Mitomycin C in a Rat Model

Esteban¹,

Atucha²,

Moraleda³

et al. 2018

Preprint

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Background. A rat model of chronic tympanic membrane perforation was developed to be used in the search of new materials for the sealing of these perforations. Methods. A longitudinal study was carried out in rats subjected to incisional myringotomy followed by the application of mitomycin C alone or with dexamethasone. Rats were checked at days 3, 7, 10, 14 and weekly thereafter until perforation closure, for up to 6 months. Results. The addition of dexamethasone is a key component in order to obtain a chronic opening. Myringotomies treated with saline had a mean healing time of 8.5 days. At 8 weeks, 70.5% of these remained perforated and at 6 months this number fell to 21.4%. Conclusion. This technique is able to maintain more than 70% of tympanic membrane perforations patent for at least 8 weeks. This rat model is adequate for its use in preclinical or translational research.

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Section: Introductionmentioning

confidence: 99%

Chronification of Tympanic Perforation with Mitomycin C in a Rat Model

Esteban¹,

Atucha²,

Moraleda³

et al. 2018

Preprint

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“…Sakagami identified several reasons why simple underlay myringoplasty with fibrin glue has been widely performed in Japan. 2 Transcanal closure of a tympanic membrane using a collagen sponge has some of the same advantages described by Sakagami. Although closure with a paper patch or tape is generally performed in traumatic perforations and after ventilation tube removal, 4,14,15 transcanal closure of a tympanic membrane using a collagen sponge can be applied to persistent tympanic perforation.…”

Section: Discussionmentioning

confidence: 94%

“…In 1989, Yuasa developed a simple underlay myringoplasty procedure using fibrin glue; 1 since then, it has been widely performed in Japan to close small dry perforations and has a high success rate without serious complications. 2,3 However, Yuasa's method does require fibrin glue, which is a relatively expensive material. Recently, transcanal closure of the tympanic membrane using a collagen sponge (Terdermis ® ), the cost of which is relatively low, has been reported in Japan [4][5][6][7][8] and small dry perforations underwent operation in the Japanese reports.…”

Section: Introductionmentioning

confidence: 99%

Clinical study of transcanal closure of tympanic membrane perforations using a collagen sponge

Tamae

Komune

2015

J. Laryngol. Otol.

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Materials and methods: We used an artificial dermis (Terdermis ® ), which is an atero-collagen sponge covered with a sheet of silicon.Patients: Nineteen ears of 17 patients with perforation of the tympanic membrane under various conditions, including large and wet perforations, underwent operation using this collagen sponge.Results: The success rate of closure after the initial surgery was 8/19. The overall success rate of closure after initial and re-operation was 14/19. The success rate of closure was 12/14 for small-sized perforations, 1/4 for middle-sized perforations and 1/1 for a large-sized perforation. Middle-and large-sized perforations required multiple surgeries. The success rate of closure was 11/11 for dry perforations, 3/4 for perforations with light otorrhoea and 0/4 for perforations with extensive otorrhoea.Conclusion: This surgery is a low-cost and minimally invasive surgery and has a high closure rate. This surgery is effective on small-sized, dry perforations although it can also close middle-and large-sized dry perforations.

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“…Controversy remains as to whether the size of perforation influences the success rate [1] [2]. The transcanal method of simple underlay myringoplasty using fibrin glue was developed in Japan [3] [6]. We performed the simple underlay myringoplasty using this technique only for dry, small-sized perforations.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Prognostic Factor for Perforation Closure Rate in Patient with Chronic Otitis Media

Katsura¹,

Mishiro²,

Ikehata³

et al. 2014

IJOHNS

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Objective: To evaluate factors affecting the perforation closure rate for perforated otitis media. Methods: Between 2008 and 2012, a total of 118 patients with perforated chronic otitis media underwent tympanoplasty at Hyogo College of Medicine Hospital by a single surgeon. Prognostic factors were analyzed using multivariate analysis with logistic regression. Results: The success rate for tympanic perforation was 93.2%. Factors showing significance on multivariate analysis were dryness of perforation and patient age at the time of surgery. Conclusion: The results suggest that pre-surgical treatment is a key factor influencing the closure rate.

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Simple underlay myringoplasty

Abstract: Simple underlay myringoplasty is a simple and minimally invasive procedure employing fibrin glue and has led to a high closure rate of the eardrum.

Cited by 42 publications

References 7 publications

Chronification of Tympanic Perforation with Mitomycin C in a Rat Model

Chronification of Tympanic Perforation with Mitomycin C in a Rat Model

Clinical study of transcanal closure of tympanic membrane perforations using a collagen sponge

Evaluation of Prognostic Factor for Perforation Closure Rate in Patient with Chronic Otitis Media

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