Clinical study of transcanal closure of tympanic membrane perforations using a collagen sponge

Abstract

Materials and methods: We used an artificial dermis (Terdermis ® ), which is an atero-collagen sponge covered with a sheet of silicon.Patients: Nineteen ears of 17 patients with perforation of the tympanic membrane under various conditions, including large and wet perforations, underwent operation using this collagen sponge.Results: The success rate of closure after the initial surgery was 8/19. The overall success rate of closure after initial and re-operation was 14/19. The success rate of closure was 12/14 for small-sized perforations, 1/4 for middle-sized perforations and 1/1 for a large-sized perforation. Middle-and large-sized perforations required multiple surgeries. The success rate of closure was 11/11 for dry perforations, 3/4 for perforations with light otorrhoea and 0/4 for perforations with extensive otorrhoea.Conclusion: This surgery is a low-cost and minimally invasive surgery and has a high closure rate. This surgery is effective on small-sized, dry perforations although it can also close middle-and large-sized dry perforations.

A Systematic Review of Nonautologous Graft Materials Used in Human Tympanoplasty

“…The authors found this material to require multiple interventions to obtain perforation closure. After a single application, only 42.1% of perforations closed, but upon multiple revisions, closure was achieved in 73.7% of patients 69 . No hearing outcomes or posttreatment complications of atelocollagen were reported, nor were there adequate data to compare outcomes in acute versus chronic perforations.…”

Principles and development of collagen-mediated tissue fusion induced by laser irradiation

“…Collagen-based biomaterial can be used as a cell culture medium to provide a scaffold to aid cell growth 28 . Otolaryngologists use collagen-based biomaterial in this way for eardrum surgery, and techniques for repairing the tympanic membrane using a collagen sponge as a scaffold are advancing 29 . Collagen tissue, therefore, shows promise for promoting wound healing.…”

Regeneration of the tympanic membrane using fibroblast growth factor-2

“…Confounding factors were obvious in these clinical studies on chronic tympanic membrane perforation. In addition, some studies reported higher success rates for regeneration in cases of chronic tympanic membrane perforation using Gelfoam or an atelocollagen/silicone bilayer membrane patch alone 41 , 42 . Thus, the specific effects of fibroblast growth factor-2 on chronic tympanic membrane perforations have not previously been well-demonstrated.…”

“…The important value of fibroblast growth factor-2 may be the regeneration in cases of chronic tympanic membrane perforation; however, the success rate of a single application of fibroblast growth factor-2 on chronic tympanic membrane perforations was very low. In addition, topical application of biomaterial alone could achieve a higher success rate 41 , 42 . Thus, the evidence for fibroblast growth factor-2 repairing chronic tympanic membrane perforations is limited.…”