Simple preparation of fused pyrrolo[2,3-b]pyrrolidinones and pyrrolo[2,3-c]pyridazinones 1

Okamoto, Yoshinari; Kaneda, Yumiko; Yamasaki, Tetsuo; Okawara, Tadashi; Furukawa, Mitsuru

doi:10.1039/a607816h

Cited by 12 publications

(2 citation statements)

References 8 publications

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“…CK130) and 1,2,3,3a,4,5,6,7,8,8a-decahydro-1,8-dibenzyl-3a,6,6d-trimethyl-2,4-dioxopyrrolo [2,3-b]indole (CK131)* were synthesized by published methods [15] and their chemical structures are presented in Figure 1. Hyamine hydroxide (a cell solubilizer), CytoScint scintillation cocktail, [3H]leucine (121 Ci/mmol), [3H]uridine (44 Ci/mmol), and [3H]thymidine (64 Ci/mmol) were purchased from ICN Radiochemicals (Irvine, CA).…”

Section: Methodsmentioning

confidence: 99%

Anti-uveitis and inhibition of fibroblast-like corneal and conjunctival cells by interleukin-1 blockers

Xuan

Chiou

1998

Inflammopharmacol

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Effects of interleukin-1 (IL-1) blockers, CK130 and CK131, on IL-1-induced uveitis and proliferation of fibroblast-like corneal and conjunctival cells were investigated in this study. It was found that CK130 and CK131 inhibited IL-1-induced uveitis in rat eyes effectively at 3 mg/kg and 10 mg/kg, respectively. Further, CK130 and CK131 inhibited fibroblast-like corneal and conjunctival cell growth effectively at 10-300 microg/ml and 30-300 microg/ml, respectively. It was also found that DNA synthesis was markedly reduced by CK130 and CK131 at 30-100 microg/ml. RNA synthesis was also inhibited by these CK compounds but protein synthesis was little affected or enhanced.

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Section: Methodsmentioning

confidence: 99%

Anti-uveitis and inhibition of fibroblast-like corneal and conjunctival cells by interleukin-1 blockers

Xuan

Chiou

1998

Inflammopharmacol

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“…However, all these and other papers were focusing on the synthesis of the 4‐hetaryl derivatives (like 3 and 5 ; Scheme ), while to the best of our knowledge, only few reports describe the synthesis of 4,4‐dimethylchromene and 4‐methyl‐4‐(methoxymethyl)‐chromene , spiroindenoquinoxaline chromene and pyrazole , 4,4‐disubstituted pyrano[2,3‐ c ]pyrazoles with different substituents as well as spiro derivatives , but not a single report has ever described the 4‐hetaryl‐4‐methyl derivatives (like A and B ; Fig. ).…”

Section: Introductionmentioning

confidence: 99%

An Eco‐friendly Synthesis of Some Novel 4‐methyl‐4‐hetaryl Chromene and Pyrano[2,3‐c]pyrazole Derivatives

Abdelrazek

Metz

Jäger

et al. 2017

Journal of Heterocyclic Chem

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in Wiley Online Library (wileyonlinelibrary.com).Some novel chromene and pyrano [2,3-c]pyrazole derivatives could be achieved successfully by reacting cyclic β-diketones with 2-acetylfuran/2-acetylthiophene and malononitrile in a one-pot synthesis. Active methylene pyrazolones reacted with 2-(1-furan-2-yl-ethylidene)-malononitrile and 2-(1-thiophen-2-ylethylidene)-malononitrile derivatives to afford the desired pyrano[2,3-c]pyrazole derivatives. Structures of all new compounds were established based on analytical and spectral data as well as X-ray crystallography. A plausible mechanism for the reaction is suggested. The solvents and catalyst used are environmentally benign, and no hazardous solvents or heavy metals were involved. J. Heterocyclic Chem., 54, 2313 (2017. RESULTS AND DISCUSSIONSynthesis of the chromene derivatives 8a-d. Cyclohexa-1,3-dione 1a and dimedone 1b were allowed to react with 2-acetylfuran 6a/2-acetylthiophene 6b and malononitrile

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ChemInform Abstract: Simple Preparation of Fused Pyrrolo(2,3‐b)pyrrolidinones and Pyrrolo(2, 3‐c)pyridazinones.

et al. 1997

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Simple preparation of fused pyrrolo[2,3-b]pyrrolidinones and pyrrolo[2,3-c]pyridazinones 1

Cited by 12 publications

References 8 publications

Anti-uveitis and inhibition of fibroblast-like corneal and conjunctival cells by interleukin-1 blockers

Anti-uveitis and inhibition of fibroblast-like corneal and conjunctival cells by interleukin-1 blockers

An Eco‐friendly Synthesis of Some Novel 4‐methyl‐4‐hetaryl Chromene and Pyrano[2,3‐c]pyrazole Derivatives

ChemInform Abstract: Simple Preparation of Fused Pyrrolo(2,3‐b)pyrrolidinones and Pyrrolo(2, 3‐c)pyridazinones.

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