Simple Isoquinoline and Benzylisoquinoline Alkaloids as Potential Antimicrobial, Antimalarial, Cytotoxic, and Anti-HIV Agents

Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids

“…For the same purpose, there have also been numerous studies on antimicrobial activity of natural products including phenolics and alkaloids (Iwasa et al, 2001;Cushnie & Lamb, 2005;Gul & Hamann, 2005;Ríos & Recio, 2005;Khan et al, 2005;Orhan et al, 2007). In many cases, antimicrobial effects of various plant extracts have been attributed to their flavonoid contents (Tsao et al, 1982;Cafarchia et al, 1999).…”

Synthesis of Isoquinolinones via Regioselective Palladium-Catalyzed C–H Activation/Annulation

“…Among a variety of bases evaluated, inorganic bases generally facilitated the transformation, and the organic base DIPEA (N,N-diisopropylethylamine) showed the best efficiency. In contrast, the yield became very poor when DBU was present (entries [11][12][13][14]. Next, common solvents, such as THF, DMF, and 1,2-dichloroethane, were screened.…”

“…Due to their unique DNA binding properties, isoquinolines and their derivatives show a wide range of biological activities, such as in vasodilatation [5][6][7], as well as for its antibacterial [3,8,9], anti-malarial [10], anti-HIV [11,12] and anti-tumor properties [13][14][15].…”

A novel isoquinoline alkaloid, DD-carboxypeptidase inhibitor, with antibacterial activity isolated from Streptomyces sp. 8812. Part I: Taxonomy, fermentation, isolation and biological activities

“…16,17 Some of them show an activity toward S. aureus, which is analogous to JS-1. Iwasa et al 18 described antimicrobial, antimalarial, cytotoxic and anti-HIV activities of simple, natural and synthetic isoquinoline and benzylisoquinoline alkaloids. Some simple alkaloids were significantly active in each assay; especially those with a quaternary nitrogen atom of isoquinolinum or dihydroisoquinolinum type may contribute to enhanced potency in the first three types of activites.…”

“…Some simple alkaloids were significantly active in each assay; especially those with a quaternary nitrogen atom of isoquinolinum or dihydroisoquinolinum type may contribute to enhanced potency in the first three types of activites. 18 This study reports the discovery of a simple isoquinoline alkaloid, JS-1, and its biological activity.…”