Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids

Özçelık, Berrın; Kartal, Murat; Orhan, İlkay Erdoğan

doi:10.3109/13880209.2010.519390

Cited by 436 publications

(273 citation statements)

References 34 publications

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“…The cytotoxic effect of plants is principally contributed by the presence of secondary metabolites like alkaloid, glycoside, steroid, tannin, phlobatannin, terpenoid and flavonoid in their extract [36] . This is also consistent with our observation because the phytochemical group analysis of the extract showed the presence of alkaloid, terpenoids, tannins, phlobatannins, steroids, flavonoids and saponins.…”

Section: Cytotoxic Activity Of L Aspera Extractmentioning

confidence: 99%

Antioxidant, antibacterial and cytotoxic effects of the phytochemicals of whole Leucas aspera extract

Rahman

Islam

2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Cytotoxic Activity Of L Aspera Extractmentioning

confidence: 99%

Antioxidant, antibacterial and cytotoxic effects of the phytochemicals of whole Leucas aspera extract

Rahman

Islam

2013

Asian Pacific Journal of Tropical Biomedicine

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“…15 Interestingly, potent antibacterial activity has been reported for scopolamine (MIC values as low as 2 µg/mL against multiple bacteria). 16 Similarly, nicotine inhibits the growth of E. coli, P. aeruginosa and S. faecalis. 17 However, it is noteworthy that all of these alkaloids have been reported to have substantial toxicity, which may limit the usable safe doses.…”

Section: Discussionmentioning

confidence: 99%

“…Scopolamine is a potent inhibitor of the growth of multiple bacteria, with MIC values as low as 2 µg/mL against some bacteria. 16 Similarly, nicotine inhibits the growth of E. coli, P. aeruginosa and S. faecalis. 17 However, MIC values were not determined in that study, making it impossible to compare the efficacy with other studies.…”

Section: Introductionmentioning

confidence: 99%

Duboisia leichhardtii (F.Muell.) Extracts Inhibit The Growth of Bacterial Triggers of Selected Autoimmune Inflammatory Diseases

Cock¹

2016

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Introduction: Duboisia leichhardtii F.Muell. is a medium to large tree which is native to subtropical regions of eastern Australia. Duboisia spp. contain a number of psychoactive tropane and pyrrolidine alkaloids with reported antibacterial activity. Despite this, D. leichhardtii leaf extracts have not been rigorously examined for growth inhibitory properties against many bacteria, including the bacterial triggers of autoimmune inflammatory diseases. Methods: The antimicrobial activity of D. leichhardtii leaf solvent extracts was investigated by disc diffusion and growth time course assays against a panel of bacterial triggers of autoimmune diseases. The growth inhibitory activity was further quantified by MIC determination and growth time course assays. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: Methanolic and aqueous D. leichhardtii leaf solvent extracts were potent inhibitors of the bacterial triggers of rheumatoid arthritis and ankylosing spondylitis. The methanolic extract displayed the most potent bacterial growth inhibitory activity. It was particularly potent against P. mirabilis (MICs of 85 and 116 µg/mL against reference and clinical strains respectively) and P. vulgaris (MIC of 187 µg/mL). The methanolic extract was also a good inhibitor of K. pneumoniae growth (MICs of 143 and 118 µg/mL against reference and clinical strains respectively). The aqueous and ethyl acetate extracts were also potent bacterial growth inhibitors, albeit with higher MIC values. The antibacterial activity of the methanolic and aqueous D. leichhardtii leaf extracts were further investigated by growth time course assays which showed significant growth inhibition in cultures of P. mirabilis and K. pneumoniae within 1 h of exposure. All extracts were determined to be nontoxic in the Artemia franciscana nauplii bioassay, indicating their safety for use in preventing these autoimmune inflammatory diseases. Conclusions: The lack of toxicity of the D. leichhardtii leaf extracts and their growth inhibitory bioactivity against the bacterial triggers of rheumatoid arthritis and ankylosing spondylitis indicate their potential in the development of new therapies targeting the onset of these diseases.

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“…Також флавоноїди виявляють протизапаль-ний, антибіотикоподібний потенціал: діючи як антимікробні агенти, пригнічують функціону-вання патогенних мікроорганізмів [12,15].…”

Section: вступunclassified

Превентивна Та Лікувальна Ефективність Біофлавоноїдів У Дітей З Рекурентними Респіраторними Інфекціями

Муквіч¹,

Kaminskaya²

2021

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Мета роботи. Підвищення ефективності лікування та профілактики гострих рекурентних респіраторних інфекцій (ГРРІ) шляхом застосування сиропу Імунофлазід® у дітей молодшого шкільного віку. Матеріали і методи. Обстежено 50 дітей молодшого шкільного віку з ГРРІ. Ефективність застосування сиропу Імунофлазід® визначалась шляхом порівняння динаміки клінічних симптомів, особливостей мікрокристалізації слини, бактеріального складу фарингеального ексудату до дослідження та через рік проведення лікувально-профілактичних курсів. Висновки. Сироп Імунофлазід® при лікувально-профілактичному застосуванні сприяє покращанню загального стану здоров’я дітей, зменшенню проявів інтоксикаційного, астенічного синдромів, частоти та тяжкості перебігу гострих респіраторних інфекцій, кількості днів пропусків занять у школі, числа та тривалості госпіталізацій, нормалізації кристалоутворюючого потенціалу слини на тлі зменшення мікробіологічного навантаження ротової порожнини.

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Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids

Cited by 436 publications

References 34 publications

Antioxidant, antibacterial and cytotoxic effects of the phytochemicals of whole Leucas aspera extract

Antioxidant, antibacterial and cytotoxic effects of the phytochemicals of whole Leucas aspera extract

Duboisia leichhardtii (F.Muell.) Extracts Inhibit The Growth of Bacterial Triggers of Selected Autoimmune Inflammatory Diseases

Превентивна Та Лікувальна Ефективність Біофлавоноїдів У Дітей З Рекурентними Респіраторними Інфекціями

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