Simple continuous flow synthesis of linoleic and palmitic acid-coated magnetite nanoparticles

Sawisai, Rotcharin; Wanchanthuek, Ratchaneekorn; Radchatawedchakoon, Widchaya; Sakee, Uthai

doi:10.1016/j.surfin.2019.100344

Cited by 15 publications

(22 citation statements)

References 40 publications

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“…31 Various surface-coating agents, including related fatty acids such as oleic and linoleic acids, have been employed to circumvent SPION aggregation. 25,26 The average hydrodynamic size recorded for the CTT nanosystem was 99.4 ± 2.0 nm (Figure 2a), which is an ideal size for application in NSCLC. It is reported that nanocarriers with a diameter range of 10−100 nm are ideal for lung tumor penetration; meanwhile, carriers above 100 nm may be subject to removal by alveolar macrophages.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Short Antiangiogenic MMP-2 Peptide-Decorated Conjugated Linoleic Acid-Coated SPIONs for Targeted Paclitaxel Delivery in an A549 Cell Xenograft Mouse Tumor Model

Ngema,

Adeyemi,

Marimuthu

et al. 2023

ACS Omega

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The design of targeted antiangiogenic nanovectors for the delivery of anticancer drugs presents a viable approach for effective management of nonsmall-cell lung carcinoma (NSCLC). Herein, we report on the fabrication of a targeted delivery nanosystem for paclitaxel (PTX) functionalized with a short antimatrix metalloproteinase 2 (MMP-2) CTT peptide for selective MMP-2 targeting and effective antitumor activity in NSCLC. The fabrication of the targeted nanosystem (CLA-coated PTX-SPIONs@CTT) involved coating of superparamagnetic iron-oxide nanoparticles (SPIONs) with conjugated linoleic acid (CLA) via chemisorption, onto which PTX was adsorbed, and subsequent surface functionalization with carboxylic acid groups for conjugation of the CTT peptide. CLA-coated PTX SPIONs@CTT had a mean particle size of 99.4 nm and a PTX loading efficiency of ∼98.5%. The nanosystem exhibited a site-specific in vitro PTX release and a marked antiproliferative action on lung adenocarcinoma cells. The CTT-functionalized nanosystem significantly inhibited MMP-2 secretion by almost 70% from endothelial cells, indicating specific anti-MMP-2 activity. Treatment of tumor-bearing mice with subcutaneous injection of the CTT-functionalized nanosystem resulted in 69.7% tumor inhibition rate, and the administration of the nanosystem subcutaneously prolonged the half-life of PTX and circulation time in vivo. As such, CLA-coated PTX-SPIONs@CTT presents with potential for application as a targeted nanomedicine in NSCLC management.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Short Antiangiogenic MMP-2 Peptide-Decorated Conjugated Linoleic Acid-Coated SPIONs for Targeted Paclitaxel Delivery in an A549 Cell Xenograft Mouse Tumor Model

Ngema,

Adeyemi,

Marimuthu

et al. 2023

ACS Omega

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“…The major compound presence in the extract are tetraethylene glycol (17.57%), 2-Ethoxyethyl methyl phthalate (17.40%), Palmitic Acid (16.21%), Myristic acid (5.57%), 2-Propanol, 1-chloro-, phosphate (5.41%), Oleic acid (5.13%),Phthalic acid, 3-chlorophenyl methyl ester (4.52%), Hexadecanoic acid (2.44%), Stearic acid (2.26%). Most of these compounds are reported as useful component in nanoparticle synthesis and perform various functions like stabilizers and coating agents in nanoparticle synthesis 28 – 32 . A detailed list of the compounds and chromatogram are attached with Supplementary Information .…”

Section: Resultsmentioning

confidence: 99%

“…There are 33 available photochemical peaks observed in the sample. It is considered that the presence of photochemical are mainly responsible for synthesizing metallic nanoparticles 27 [28][29][30][31][32] . A detailed list of the compounds and chromatogram are attached with Supplementary Information.…”

Section: Resultsmentioning

confidence: 99%

Cow dung extract mediated green synthesis of zinc oxide nanoparticles for agricultural applications

Javed

Tripathi²,

Mishra³

et al. 2022

Sci Rep

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In the present study, zinc oxide nanoparticles (ZnO) were synthesized using cow dung extract to apply sustainable agriculture from rural resources. Studies on their antibacterial potential against E. coli DH 5 alpha indicated lower antimicrobial activities than the bulk Zn and commercial Zn nanoparticles. Compared with control and commercial ZnO nanoparticles, the maximum seed germination, root length, and shoot length were observed after the priming of synthesized ZnO NPs. This study suggests that ZnO may significantly increase seed germination and have lower antimicrobial potential. Further, the lower in-vitro cellular leakage and reactive oxygen species (ROS) production provided new hope for using cow dung extract mediated nanoparticles for agricultural and industrial applications.

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“…The Lifshitz-van der Waals parameter (γ LW i ), on DP covered magnetite surface was significantly increased from 49.3 mJ/m 2 to 92.3 mJ/m 2 . The properties and working mechanisms of the The surface tension values of liquids are taken from Sawisai et al (2019 andvan Oss (1993). OA surfactant cover layer and DP surfactant cover layer were different.…”

Section: Theoretical Analysis Of Colloidal Stability In Polar or Apol...mentioning

confidence: 99%

“…The magnetic particles in ordinary ferrofluids are generally coated by a variety of long-chain organic surfactants (Hong et al, 2008;Okabe et al, 2017;Shi et al, 2018;Kumar et al, 2021;Kumar et al, 2022). These surfactants have a polar hydrophilic head group and an apolar hydrophobic end (Sawisai et al, 2019). The surfaces of magnetic iron oxide are generally hydrophilic, which enables these surfaces to be combined with the polar head group of surfactants.…”

Section: Introductionmentioning

confidence: 99%

Colloidal Stability of Magnetite Nanoparticles Coated by Oleic Acid and 3-(N,N-Dimethylmyristylammonio)propanesulfonate in Solvents

2022

Front. Mater.

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In order to understand the factors affecting the colloidal stability in the carrier liquids of different ferrofluids, magnetite nanoparticles coated by surfactants 3-(N,N-dimethylmyristylammonio)propanesulfonate (DP) and oleic acid (OA) were fabricated as dispersions in diverse colloidal systems. The OA-coated magnetite could only be dispersed in the apolar carrier liquid (εr < 5), while DP-coated magnetite particles could establish a stable colloidal system in the polar base liquid (εr > 5) such as water and ethanol. The colloidal stability of OA-coated particles in the apolar solvents was mainly attributed to the steric repulsion of its outer thick liquid shell (∼3 nm). Due to the absence of steric repulsion on the solid thin shell (∼1 nm) on DP-coated magnetite, DP-coated particles could not be dispersed in the apolar liquid. In the polar liquid-based ferrofluids, DP-coated magnetite could form an electric double layer (EDL). The total Gibbs interfacial energy was analyzed based on Van Oss-Chaudhry-Good and DLVO theory to describe the behaviors of coated particles in solvents. In the case of neutral (pH = 7) water-based colloidal, DP-coated magnetite could establish an energy barrier of ∼2.2 kBT to prevent the particles from precipitation. Bare magnetite particles could form a relatively fragile colloid in a water system with an energy repulsion of ∼1.2 kBT. In contrast, OA-coated magnetite exhibited a severe phase separation in a water-based colloidal system due to its net attraction ∼ −1.3 kBT.

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Simple continuous flow synthesis of linoleic and palmitic acid-coated magnetite nanoparticles

Cited by 15 publications

References 40 publications

Short Antiangiogenic MMP-2 Peptide-Decorated Conjugated Linoleic Acid-Coated SPIONs for Targeted Paclitaxel Delivery in an A549 Cell Xenograft Mouse Tumor Model

Short Antiangiogenic MMP-2 Peptide-Decorated Conjugated Linoleic Acid-Coated SPIONs for Targeted Paclitaxel Delivery in an A549 Cell Xenograft Mouse Tumor Model

Cow dung extract mediated green synthesis of zinc oxide nanoparticles for agricultural applications

Colloidal Stability of Magnetite Nanoparticles Coated by Oleic Acid and 3-(N,N-Dimethylmyristylammonio)propanesulfonate in Solvents

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