Simple and fast method for the measurement of legacy and novel brominated flame retardants in human serum

Pirard, Catherine; Charlier, Corinne

doi:10.1016/j.chemosphere.2018.08.012

Cited by 17 publications

(3 citation statements)

References 34 publications

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“…Recently, there have been many studies involving the occurrence of several NBFRs in various environmental matrices, including air, , dusts, , sewage sludge, , and sediments, , as well as human serum. , It is worth noting that NBFRs have also been found in the Arctic, which indicates that these compounds can undergo a long-range atmospheric transport (LRAT), just as the restricted and banned traditional BFRs . Bioaccumulation potential and adverse effects of NBFRs have been documented, , which is worthy of attention because they may have the same properties as the restricted and banned BFRs, particularly considering their physical and chemical similarities to traditional BFRs.…”

Section: Introductionmentioning

confidence: 99%

A Review of Environmental Occurrence, Fate, and Toxicity of Novel Brominated Flame Retardants

Xiong

Yan

Zhu

et al. 2019

Environ. Sci. Technol.

249

104

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Use of legacy brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCD), has been reduced due to adverse effects of these chemicals. Several novel brominated flame retardants (NBFRs), such decabromodiphenyl ethane (DBDPE) and bis(2,4,6-tribromophenoxy) ethane (BTBPE), have been developed as replacements for PBDEs. NBFRs are used in various industrial and consumer products, which leads to their ubiquitous occurrence in the environment. This article reviews occurrence and fate of a select group of NBFRs in the environment, as well as their human exposure and toxicity. Occurrence of NBFRs in both abiotic, including air, water, dust, soil, sediment and sludge, and biotic matrices, including bird, fish, and human serum, have been documented. Evidence regarding the degradation, including photodegradation, thermal degradation and biodegradation, and bioaccumulation and biomagnification of NBFRs is summarized. The toxicity data of NBFRs show that several NBFRs can cause adverse effects through different modes of action, such as hormone disruption, endocrine disruption, genotoxicity, and behavioral modification. The primary ecological risk assessment shows that most NBFRs exert no significant environmental risk, but it is worth noting that the result should be carefully used owing to the limited toxicity data.

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Section: Introductionmentioning

confidence: 99%

A Review of Environmental Occurrence, Fate, and Toxicity of Novel Brominated Flame Retardants

Xiong

Yan

Zhu

et al. 2019

Environ. Sci. Technol.

249

104

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“…Accuracy and precision were also determined through the data obtained with three series on independent days. The acceptance limits of the accuracy profiles were set at ±20% of the nominal concentrations, and the tolerance limit was set at 17.5% in accordance with the literature [ 32 , 33 ]. The tolerance limit was evaluated through the percentage of risk of having measurements fall outside of the acceptance limits for each level of concentration.…”

Section: Methodsmentioning

confidence: 99%

An Intravenous Pharmacokinetic Study of Cannabidiol Solutions in Piglets through the Application of a Validated Ultra-High-Pressure Liquid Chromatography Coupled to Tandem Mass Spectrometry Method for the Simultaneous Quantification of CBD and Its Carboxylated Metabolite in Plasma

Koch,

Jennotte,

Lechanteur

et al. 2024

Pharmaceutics

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Cannabidiol (CBD) has multiple therapeutic benefits that need to be maximized by optimizing its bioavailability. Numerous formulations are therefore being developed and their pharmacokinetics need to be studied, requiring analytical methods and data from intravenous administration. As CBD is susceptible to hepatic metabolism, the requirement of any method is to quantify metabolites such as 7-COOH-CBD. We demonstrated that CBD and 7-COOH-CBD could be simultaneously and correctly quantified in piglet plasma by using an UHPLC–MS/MS technique. The validated method allowed for an accurate bioanalysis of an intravenously injected solution consisting of CBD-HPβCD complexes. The experimental pharmacokinetic profile of CBD showed multi-exponential decay characterized by a fast apparent distribution half-life (0.25 h) and an elimination half-life of two hours. The profile of 7-COOH-CBD was not linked with the first-pass metabolism, since 80% of the maximum metabolite concentration was reached at the first sampling time point, without any decrease during the period of study. A two-compartment model was optimal to describe the experimental CBD profile. This model allowed us to calculate macro–micro constants and volumes of distribution (Vss = 3260.35 ± 2286.66 mL) and clearance (1514.5 ± 261.16 mL·h−1), showing that CBD is rapidly distributed to peripheral tissues once injected and slowly released into the bloodstream.

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“…The methodology to quantify 8 polybrominated diphenylethers (PBDEs) (namely, BDE-28, -47, -99, -100, -153, -154, -183 and -209) has been described in Pirard and Charlier, 2018 [18]. In summary, serum sample, quality control sample, and standard calibration sample were denaturized with a glacial acetic acid/water mixture (3/7, v/v) and then extracted twice with a mixture of hexane and acetone (95/5, v/v).…”

Section: Analysis Of Bfrs In Serummentioning

confidence: 99%

Bio-surveillance of environmental pollutants in the population of Kinshasa, Democratic Republic of Congo (DRC): A small pilot study

Bayebila

Dufour

Pirard

et al. 2021

Preprint

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BackgroundEnvironmental pollutants are known to be ubiquitous and may present toxic effects (endocrine-disruption properties, carcinogenicity…). Therefore, they represent a real threat to human health. The aim of the present study was to assess the content of environmental pollutants (inorganic, persistent, and non-persistent pollutants) in biological samples (urine, serum, and whole blood), collected from volunteers in Kinshasa, capital of Democratic Republic of Congo, in order to estimate the exposure level in the population of Kinshasa to environmental pollutants.MethodsFrom randomly selected 15 volunteers living in Kinshasa, aged from 25 to 66 years, including 10 men and 5 women, urine, whole blood, and serum samples were used in this study to estimate the contents in these environmental pollutants, using Inductively Coupled Plasma Mass Spectrometry, Gas Chromatography coupled to Mass Spectrometry, and Liquid Chromatography coupled to Mass Spectrometry.ResultsWhen compared to data nationally and internationally available, the preliminary outcomes of this study indicated a high level of exposure to environmental pollutants in the population of Kinshasa, especially for arsenic, cadmium, lead, benzophenone-3, methyl-paraben, propyl-paraben, triclosan, mono-ethyl phthalate, mono-n-butyl phthalate, 3-phenoxybenzoic acid, cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid, and for 3,5,6-trichloro-2-pyridinol. The levels of 4,4’dichloro-diphenyl-dichloro-ethylene and glyphosate were also significant although some heavily exposed populations showed higher level of contamination. In contrast, the investigated population of Kinshasa was found to weakly exposed to other pollutants like bisphenol A, dialkyl phosphates, polychlorinated biphenyls, brominated flame retardants, phenolic organo-halogens, and perfluoroalkyl substances.ConclusionAlthough the biologic fluids were collected from a limited number of volunteers (n = 15), the results of the present report clearly indicate that the population of Kinshasa is not spared by the investigated environmental pollutants.Trial registration: this study was retrospectively registered by the national health ethics committee in the Congo under the series number of 159/CNES/BN/PMMF/2020.

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Simple and fast method for the measurement of legacy and novel brominated flame retardants in human serum

Cited by 17 publications

References 34 publications

A Review of Environmental Occurrence, Fate, and Toxicity of Novel Brominated Flame Retardants

A Review of Environmental Occurrence, Fate, and Toxicity of Novel Brominated Flame Retardants

An Intravenous Pharmacokinetic Study of Cannabidiol Solutions in Piglets through the Application of a Validated Ultra-High-Pressure Liquid Chromatography Coupled to Tandem Mass Spectrometry Method for the Simultaneous Quantification of CBD and Its Carboxylated Metabolite in Plasma

Bio-surveillance of environmental pollutants in the population of Kinshasa, Democratic Republic of Congo (DRC): A small pilot study

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