Simple and efficient synthetic routes to bioactive s-triazinyl dithiocarbamate derivatives

Abstract

Series of 2,4-diarylamino-6-[N-(3 0 -methylphenyl)dithiocarbamoyl]-striazines (4a-l) and 2,4-bis[N-(3 0 -methylphenyl)dithiocarbamoyl]-6-arylamino-striazines (7a-l) were synthesized by two different synthetic routes. In the first route (A), 2,4,6-tricholoro-s-triazine (1) was condensed with N-(3-methylphenyl)ammoniumdithiocarbamate to afford compounds 3 or 6, which on reaction with different aryl amines afforded compounds 4a-l or 7a-l. In the second route (B), condensation of 1 with different aryl amines yielded compounds 2a-l or 5a-l. On further treatment with N-(3-methylphenyl)ammoniumdithiocarbamate these afforded compounds 4a-l or 7a-l. The newly synthesized compounds 4a-l and 7a-l were characterized by elemental analyses, infrared (IR), and 1 H nuclear magnetic resonance (NMR) spectroscopic investigation. All the products were evaluated for their antibacterial and antifungal activity.

Synthesis and biological evaluation of novel benzothiophene derivatives

“…The organic layer was dried over anhydrous MgSO 4 and filtered. Solvent was removed under vacuum, and the residue was purified by column chromatography over silica gel with Hexane/EtOAc (10/1) to afford 3-(1H-indole-2-yl)-2-(thiophen-2-yl) benzo [ 28 on the basis of Clinical and Laboratory Standards Institute (CLSI) recommendation. The results were recorded for each tested compound as the average diameter (in mm) of inhibition zones around the discs where no microbial growth occurred.…”