Simple and efficient syntheses of novel benzo[4,5]imidazo[1,2-a]pyridine derivatives

Efficient three-component synthesis of N-alkyl-3,6-diaryl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-7-amines under solvent-free condition

“…In continuation of our researches on preparation of N-containing organic compounds, [32][33][34][35][36][37] herein, we report a novel and efficient approach for the green synthesis of N-alkyl-3,6-diaryl- [1,2,4]triazolo [4,3-b] [1,2,4]triazin-7-amines 4a-h, via three-component reaction of 5-aryl-4H-1,2,4-triazole-3,4-diamine 1, isocyanide 2, and aldeyhde 3, under solvent-free condition at 150 C (Scheme 1). The reactions went to completion within 4 hours and the corresponding products 4 were obtained in 68-82% yields.…”

Synthesis of Novel Thiophene, Thiazole and Coumarin Derivatives Based on Benzimidazole Nucleus and Their Cytotoxicity and Toxicity Evaluations

“…The shrimp lethality assay is considered as a useful tool for preliminary assessment of toxicity, and it has been used for the detection of fungal toxins, plant extract toxicity, heavy metals, cyanobacteria toxins, pesticides, and cytotoxicity testing of dental materials. 43) It has also been shown that, A. salina toxicity test results have a correlation with rodent and human acute oral toxicity data. Generally, a good correlation was obtained between A. salina toxicity test and the rodent data.…”

“…Chemistry Preparation of the 2-(1H-Benzo[d]imidazol-2-yl)acetonitrile (1) 44) To the dry solid of o-phenylene diamine (1.08 g, 0.01 mol), ethyl caynoacetate (1.13 g, 0.01 mol) was added. The reaction mixture was heated in an oil bath at 120°C for 30 min then was left to cool.…”

Synthesis of Novel Pyrazino[2,1-a]isoindoledionesviaIntramolecular Hydroamination of 2,3-Dihydro-3-oxo-2-(prop-2-yn-1-yl)-1H-isoindole-1-carboxamides

“…In this study, pyrazino[2,1‐ a ]isoindoles absorbed our attention due to the lack of versatile procedure for their synthesis. Herein, in continuation of our work on the synthesis of novel heterocyclic compounds as well as hydroamination reaction , we describe synthesis of novel pyrazino[2,1‐ a ]isoindolediones 5 through the 6‐ exo ‐ dig intramolecular hydroamination of 2,3‐dihydro‐3‐oxo‐2‐(prop‐2‐yn‐1‐yl)‐1 H ‐isoindole‐1‐carboxamides 4 (Scheme). …”