Simple and complex dysembryoplastic neuroepithelial tumors (DNT) variants: clinical profile, MRI, and histopathology

Campos, Alexandre Rainha; Clusmann, Hans; Lehe, Marec von; Niehusmann, Pitt; Becker, Albert J.; Schramm, Johannes; Urbach, Horst

doi:10.1007/s00234-009-0511-1

Cited by 110 publications

(71 citation statements)

References 20 publications

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“…DNET can be recognized on MR imaging—as on histopathological analysis—from its glioneuronal element, with multiple T1-hypointense and T2-hyperintense “pseudocystic” areas of different sizes which return variable FLAIR (fluid-attenuated inversion recovery) signal [14]. These may have surrounding high signal on FLAIR separate from the glioneuronal element.…”

Section: Discussionmentioning

confidence: 99%

Multifocal Dysembryoplastic Neuroepithelial Tumour with Intradural Spinal Cord Lipomas: Report of a Case

White

Kanodia

Sammler

et al. 2011

Case Reports in Radiology

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We report a case of temporal lobe epilepsy and incomplete Brown-Sequard syndrome of the thoracic cord. Computed tomography and magnetic resonance (MR) imaging showed multiple supratentorial masses with the classical radiological appearances of multifocal dysembryoplastic neuroepithelial tumour (DNET). Spinal MR imaging revealed intradural lipomas, not previously reported in association with multifocal DNET. Presentation and imaging findings are discussed along with classification and natural history of the tumour.

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Section: Discussionmentioning

confidence: 99%

Multifocal Dysembryoplastic Neuroepithelial Tumour with Intradural Spinal Cord Lipomas: Report of a Case

White

Kanodia

Sammler

et al. 2011

Case Reports in Radiology

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“…Among DNTs two histological variants have been identified: the simple variant is characterized by the glioneural element, whereas the complex variant contains additionally glial nodules resembling astrocytomas or oligodendroglial tumors. From a clinical point of view, patients with complex DNT variants have an earlier seizure onset than patients with simple variants, and complex DNT variants are more likely to be located outside the temporal lobe [12 ]. Sometimes the differential diagnosis between these grade I tumors and the most common grade II gliomas is challenging due to sampling problems.…”

Section: Epidemiology and Pathologymentioning

confidence: 99%

Epilepsy and brain tumors

Rudà

Trevisan

Soffietti

2010

Current Opinion in Oncology

155

104

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“…[1][2][3][4] Being a grade I tumor, a total removal is also the best treatment. [1][2][3][4] In this patient, the neurological signs and symptoms were caused by the intra-tumoral hemorrhage. With a gross total removal of the tumor, the three main objectives of the surgery were achieved: oncological cure, epilepsy control and resolution of neurologic deficits.…”

Section: Discussionmentioning

confidence: 99%

“…They appear in children and young adults [22.1 ± 11.2 years (range: 8 months -67 years)] and are usually located in the temporal lobes (71.3%). [1][2][3][4] The most common presenting symptom is seizure (80% -100%) with hemorrhage reported very seldom. 5,6 Intraventricular gangliogliomas are also very rare with only 21 reported cases in a recent review.…”

Section: Introductionmentioning

confidence: 99%

Intraventricular Ganglioglioma Presenting with Spontaneous Hemorrhage

Campos

Biscoito²,

Gasparinho

2018

Acta Med Port

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RESUMOOs gangliogliomas Intraventriculares com hemorragia espontânea são raros. Devido à densidade elevada de tractos importantes localizados lateralmente ao átrio ventricular, o sulco intraparietal é a via preferencial de acesso para remoção de lesões nesta localização. Um homem de 33 anos recorreu à urgência por cefaleia súbita e crise tónico-clónica generalizada. No exame neurológico, apresentava hemianopsia homónima esquerda e negligência visual esquerda. Realizou tomografia computorizada cranioencefálica e ressonância magnética que revelaram lesão ocupando espaço com hemorragia, localizada no átrio do ventrículo lateral direito. O estudo por tractografia permitiu estabelecer o corredor ideal de acesso ao tumor através do sulco intraparietal. A remoção total do ganglioglioma foi possível sem instalação de défices e com recuperação do défice visual e controle das crises epilépticas. A eficácia do uso da tractografia como ferramenta de planeamento para remoção segura de tumores é aqui apresentada com detalhes clínicos, neurorradiológicos, neuropatológicos e um vídeo cirúrgico. Palavras-chave: Epilepsia; Ganglioglioma/cirurgia; Imagem de Tensor de Difusão; Neoplasias do Ventrículo Cerebral ABSTRACT Intraventricular gangliogliomas presenting with spontaneous hemorrhage are rare. Due to high density of important tracts lateral to the ventricular atrium, the intraparietal trans sulcal approach is a good option to remove lesions in this location. These tracts are displaced and sometimes destroyed by the presence of large masses. A 33-year-old male presented with a sudden headache and a generalized seizure. He had a left visual field hemianopia and left visual field neglect. Brain computer tomography and magnetic resonance imaging revealed a hemorrhagic tumor located in his right atrium. With the help of tractography an optimal corridor to the tumor through the intraparietal sulcus was planned. Gross total removal of a ganglioglioma was possible with recovery of visual impairment and control of epilepsy. The efficacy in using tractography as a planning tool for safe tumor removal is demonstrated with clinical, imagiological and histological data, and a surgical video.

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Simple and complex dysembryoplastic neuroepithelial tumors (DNT) variants: clinical profile, MRI, and histopathology

Abstract: The glioneuronal element is readily identifiable on MRI and should be considered to support the DNT diagnosis. Complex DNT variants have a different clinical profile and a more variable histopathological and MRI appearance; however, misdiagnoses occasionally also occur in simple variants.

Cited by 110 publications

References 20 publications

Multifocal Dysembryoplastic Neuroepithelial Tumour with Intradural Spinal Cord Lipomas: Report of a Case

Multifocal Dysembryoplastic Neuroepithelial Tumour with Intradural Spinal Cord Lipomas: Report of a Case

Epilepsy and brain tumors

Intraventricular Ganglioglioma Presenting with Spontaneous Hemorrhage

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