Epilepsy and brain tumors

Rudà, Roberta; Trevisan, Elisa; Soffietti, Riccardo

doi:10.1097/cco.0b013e32833de99d

Cited by 156 publications

(129 citation statements)

References 116 publications

(135 reference statements)

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“…The choice of drug for patients requiring secondary prophylaxis is guided by various considerations. 64,65 The classical drugs include carbamazepine, This document does not address the competence to drive with a brain tumor because this is subject to country-specific regulations which are beyond the scope of this guideline.…”

Section: Epilepsymentioning

confidence: 99%

EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma

Weller

Bent

Hopkins

et al. 2014

The Lancet Oncology

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670

532

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This guideline provides recommendations for diagnostic and therapeutic procedures for patients with malignant gliomas. We differentiate evidence-based standards from reasonable options or non-evidence-based measures that should no longer be considered. The recommendations herein should provide a framework and assurance for the choice of diagnostic procedures and therapeutic measures and aim to reduce complications from unnecessary treatment and cost. The guideline contributes to a critical appreciation of concurrent drugs with a focus on the controlled use of anticonvulsants and steroids. It should serve as a guideline for all professionals involved in the diagnostics and care of glioma patients and also as a source of knowledge for insurance companies and other institutions involved in the cost regulation of cancer care in Europe. Implementation of the recommendations summarised here will need interdisciplinary structures of care for patients with brain tumours and structured processes of diagnostic and therapeutic procedures. AF and DF report no conflicts of interest. FundingThe preparation of this guideline was not funded. The members of the task force did not receive compensation for their participation. 5 SummaryThis guideline provides recommendations for the diagnostic and therapeutic procedures for patients with malignant gliomas. It differentiates evidence-based standards from reasonable options or non-evidence-based measures that should no longer be considered. The recommendations herein shall provide a framework and assurance for the choice of diagnostic procedures and therapeutic measures and aim to reduce complications from unnecessary treatment and cost. The guideline will contribute to a critical appreciation of concurrent medications with a focus on the controlled use of anticonvulsants and steroids. It shall serve as a guideline for all professionals involved in the diagnostics and care of glioma patients and also as a source of knowledge for insurance companies and other institutions involved in the cost regulation of cancer care in Europe. Implementation of the recommendations summarized here will require interdisciplinary structures of care for brain tumor patients and structured processes of diagnostic and therapeutic procedures. Key wordsAnaplastic, glioma, glioblastoma, surgery, radiotherapy, temozolomide, bevacizumab Search strategy and selection criteriaThis guideline was prepared by a task force assembled by the Executive Committee of the European Association for Neuro-Oncology (EANO) in 2013. The task force was designed to represent the different disciplines involved in the diagnosis and care of malignant glioma patients as well as to reflect the multinational composition of EANO.References for this review were identified through searches of PubMed with the search terms "glioma", "anaplastic", "glioblastoma", "trial", "clinical", "radiotherapy" 6 and "chemotherapy" from January 2005 to January 2013. Articles were also identified through searches of the authors` own files. Onl...

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Section: Epilepsymentioning

confidence: 99%

EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma

Weller

Bent

Hopkins

et al. 2014

The Lancet Oncology

Self Cite

670

532

View full text Add to dashboard Cite

show abstract

“…Among the various documented toxicities of AEDs are wide-ranging adverse effects on cognitive function [23,153], which already may be impaired because of the tumour itself and the radiation therapy sometimes administered to treat it [18,20,[154][155][156]. Moreover, surgical resection of LGG has been shown to enhance long-term survival [19] and to significantly improve the likelihood of seizure control [27,70].…”

Section: General Principles Of Managementmentioning

confidence: 99%

“…Early seizures may be generalized, simple partial, complex partial, or mixed, depending upon the tumour's size, location, level of aggressiveness, and other factors [24,26,27,33,34,37,70,74,77,82,87,[110][111][112][113][114][115]. This being said, among children, seizures as a presenting symptom of brain tumour are most commonly complex or simple partial, versus generalized, with complex partial seizures generally accounting for from 50% to as high as 85% of all new-onset seizures [32,63,69,86,[115][116][117].…”

Section: How Seizures Presentmentioning

confidence: 99%

“…Why seizures occur in patients with brain tumours is not entirely clear [27,[69][70][71], and several conjectures have been made, including alterations in regional metabolism and pH, immunologic activity, disordered neuronal function, altered vascular supply and permeability, the release of altered tumoral amino acids, proteins and enzymes, and abnormal protein transport and binding to receptors [27,44,69,[71][72][73][74]. Even genetic predispositions for tumour-related seizures have been postulated [71,75].…”

Section: Introductionmentioning

confidence: 99%

“…Among the more common longterm sequelae of brain cancer and brain cancer treatment in children are seizures, which can be quite disabling and, at times, life-threatening in themselves [15,[21][22][23][24][25][26][27][28][29][30]. In one study, seizures were the number one predictor of disability in long-term brain cancer survivors [24,25].…”

Section: Introductionmentioning

confidence: 99%

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