Simple and clean determination of tetracyclines by flow injection analysis

Pérez-Rodríguez, Michael; Pezza, Helena Redigolo; Pezza, Leonardo

doi:10.1016/j.saa.2015.08.048

Cited by 52 publications

(19 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As result, colored complexes are formed and measured in the range of 290-650 nm. Nevertheless, disadvantages of the use of such reagents include low sensitivity, the need for heating or cooling, high reagent concentrations, and the presence of toxic substances and large volumes of organic solvents (Rodr ıguez et al, 2016).…”

Section: Spectrophotometrymentioning

confidence: 99%

A Critical Review of Properties and Analytical Methods for the Determination of Oxytetracyline in Biological and Pharmaceutical Matrices

Hanck-Silva

Fernandes

Trevizan

et al. 2016

Critical Reviews in Analytical Chemistry

View full text Add to dashboard Cite

Antibiotics have an unquestionable importance in the treatment of many infections. Oxytetracycline is an antibiotic belonging to the class of tetracyclines, available for use in human and veterinary medicine. Development of analytical methods that prove the quality and efficacy of these drugs is fundamentally important to the pharmaceutical industry. In this context, the research presents an overview of the analytical profile of oxytetracycline, describing its chemical and pharmacological properties, and analytical methods for quantification of this drug in biological samples and pharmaceutical products. Oxytetracycline can be analyzed in these matrices by many types of methodologies. However, high-performance liquid chromatography is the most widely used, being recommended by official compendia. This kind of study can be useful to support the development of new efficient and sustainable analytical methods that may be utilized in the quality control routine of oxytetracycline in pharmaceutical products and pharmacokinetic monitoring in biological samples.

show abstract

Section: Spectrophotometrymentioning

confidence: 99%

A Critical Review of Properties and Analytical Methods for the Determination of Oxytetracyline in Biological and Pharmaceutical Matrices

Hanck-Silva

Fernandes

Trevizan

et al. 2016

Critical Reviews in Analytical Chemistry

View full text Add to dashboard Cite

show abstract

“…The effects were not considered significant, since the changes in the tetracycline signal did not exceed 5 % [31]. Here, no interference in the reaction was observed with heating, indicating good selectivity of the proposed method with LWCC-based spectrophotometric detection.…”

Section: Fractional Factorial Design For Us-dllme Parametersmentioning

confidence: 80%

“…Both procedures provide simplicity, rapidity, cost economy, good precision, and low consumption of reagents and solvents [23,24,30,31]. In combination, they offer an environmentally safer technique for the analysis of tetracyclines in eggs and in products derived from eggs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrasound-assisted dispersive liquid–liquid microextraction of tetracycline drugs from egg supplements before flow injection analysis coupled to a liquid waveguide capillary cell

Pérez-Rodríguez

Pezza

2016

Anal Bioanal Chem

Self Cite

View full text Add to dashboard Cite

A simple, rapid, and efficient ultrasound-assisted dispersive liquid-liquid microextraction (US-DLLME) method was developed for extraction of tetracycline residues from egg supplement samples, with subsequent determination by flow injection analysis (FIA) coupled to a liquid waveguide capillary cell (LWCC) and a controlled temperature heating bath. Tetracyclines react with diazotized p-sulfanilic acid, in a slightly alkaline medium, to form azo compounds that can be measured at 435 nm. The reaction sensitivity improved substantially (5.12-fold) using an in-line heating temperature of 45 °C. Multivariate methodology was used to optimize the factors affecting the extraction efficiency, considering the volumes of extraction and disperser solvents, sonication time, extraction time, and centrifugation time. Good linearity in the range 30-600 μg L(-1) was obtained for all the tetracyclines, with regression coefficients (r) higher than 0.9974. The limits of detection ranged from 6.4 to 11.1 μg L(-1), and the recoveries were in the range 85.7-96.4 %, with relative standard deviation lower than 9.8 %. Analyte recovery was improved by approximately 6 % when the microextraction was assisted by ultrasound. The results obtained with the proposed US-DLLME-FIA method were confirmed by a reference HPLC method and showed that the egg supplement samples analyzed were suitable for human consumption.

show abstract

“…[56] In addition, it is a widely used technique in the pharmaceutical industry for monitoring, evaluating and quality control of finished products despite the high operating cost. [57] Most studies have reported UA separation by HPLC using C18 analytical columns and methanol-water or acetonitrilewater as the mobile phase with the pH adjusted between 2.8 and 6.74 using various organic additives (phosphate buffer, phosphoric acid, ammonium formate, formic acid, orthophosporic acid, and trifluoroacetic acid). The separation was conducted more frequently with isocratic elution than gradient elution.…”

Section: Methodsmentioning

confidence: 99%

Characteristics, Biological Properties and Analytical Methods of Ursolic Acid: A Review

Pironi

Araújo

Fernandes

et al. 2017

Critical Reviews in Analytical Chemistry

View full text Add to dashboard Cite

Ursolic acid (UA) is a naturally occurring triterpenoid which is a promising candidate for the development of new therapeutic approaches and for the prevention and treatment of several diseases owing to its pharmacological importance. However, its low solubility in aqueous medium affects its therapeutic application. Several strategies have been used to overcome this obstacle. In this study, the incorporation of UA in to different drug delivery systems was found to be highly efficient. In addition, important investigations were performed about methods for qualitative and quantitative analyses of UA in various raw materials, including plants, biological fluids, and drug delivery systems, were investigated. Most recently high performance liquid chromatography coupled with various detectors, gas chromatography-mass spectrometry and capillary electrophoresis were used for this purpose. Thus, this review was performed to evaluate the biological effects of UA demonstrated thus far as well as the currently used, delivery systems and analytical methods.

show abstract

Simple and clean determination of tetracyclines by flow injection analysis

Cited by 52 publications

References 33 publications

A Critical Review of Properties and Analytical Methods for the Determination of Oxytetracyline in Biological and Pharmaceutical Matrices

A Critical Review of Properties and Analytical Methods for the Determination of Oxytetracyline in Biological and Pharmaceutical Matrices

Ultrasound-assisted dispersive liquid–liquid microextraction of tetracycline drugs from egg supplements before flow injection analysis coupled to a liquid waveguide capillary cell

Characteristics, Biological Properties and Analytical Methods of Ursolic Acid: A Review

Contact Info

Product

Resources

About