Similarity of the Swine Vasculature to the Human Carotid Bifurcation: Analysis of Arterial Diameters

Bushi, Doron; Assaf, Yaniv; Grad, Ygael; Nishri, B.; Yodfat, Ofer; Tanné, David

doi:10.1016/j.jvir.2007.09.022

Cited by 13 publications

(10 citation statements)

References 22 publications

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“…The external iliac diameter (6 -7 mm) in the lower weight swine is similar to the known human common carotid artery [53]. The greatest similarity was found between the diametrical ratios of the human internal carotid artery to common carotid artery (ICA / CCA mean 0.63) and the swine profunda to external iliac (profunda / Iliac mean 0.68).…”

Section: In Vivo Imaging Of Porcine Animal Modelmentioning

confidence: 58%

“…The greatest similarity was found between the diametrical ratios of the human internal carotid artery to common carotid artery (ICA / CCA mean 0.63) and the swine profunda to external iliac (profunda / Iliac mean 0.68). This suggest that the swine iliac bifurcation can be used as a comparable anatomy to the human carotid bifurcation [53]. All procedures were carried out with institutional approval at the St. Michaels Hospital, Toronto, Canada and Sunnybrook Health Science Centre, Toronto, Canada.…”

Section: In Vivo Imaging Of Porcine Animal Modelmentioning

confidence: 99%

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Development of an Intravascular Doppler Optical Coherence Tomography Imaging Technique for Neurovascular Applications

Vuong¹

2021

Preprint

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The rupture of an intracranial aneurysm can cause spontaneous subarachnoid hemorrhage and result in sudden death. A large portion of intracranial aneurysms occurs near the center of the head, at the skull base, which poses significant technical challenge to neurosurgeons due to limited accessibility. The utilization of angiography is prominent during the treatment of intracranial aneurysms. However, malapposition of stent or incomplete packing of the intracranial aneurysm can be difficult to assess with angiography, and could lead to severe postoperative complications. As a result, angiography may not be sufficient in determining the risk of rupture as the compensatory mechanisms are known to occur at the microstructural level due to the local hemodynamics in the arterial lumen, as well as in evaluating the intraoperative treatment. In this work, we describe a method for assessing intracranial aneurysm through the evaluation of blood flow within the lumen and morphological structures of the arterial wall with optical coherence tomography (OCT). Sterile intravascular fiber-optic catheters can be introduced in the artery to detect blood flow. Prior to this work, limited investigations of catheter based Doppler OCT (DOCT) were reported. A novel signal processing technique was developed to further reduce the effect of Doppler noise within a catheter based DOCT system. This technique consisted of splitting the interferogram of an OCT signal prior to estimating the Doppler shift. This split spectrum DOCT (ssDOCT) method was evaluated through flow models and porcine models, as well as through the correlation between ssDOCT algorithm and computational fluid dynamic (CFD) models. It was observed that ssDOCT provided improved Doppler artefact suppression over the conventional DOCT technique. ssDOCT also provided the ability to estimate lower velocities within the DOCT image to measure the hemodynamic patterns around stent struts in both the internal carotid and patient specific flow phantoms. An OCT imaging study was also conducted consisting of surgically resected human intracranial aneurysms. Further enhancement of the detection of these key morphological structures was demonstrated by an optical-attenuation imaging variant of OCT. The presented techniques could provide further insights to the cause of intracranial aneurysm rupture and vascular healing mechanisms.

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Section: In Vivo Imaging Of Porcine Animal Modelmentioning

confidence: 58%

Section: In Vivo Imaging Of Porcine Animal Modelmentioning

confidence: 99%

Development of an Intravascular Doppler Optical Coherence Tomography Imaging Technique for Neurovascular Applications

Vuong¹

2021

Preprint

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“…The results of this study clearly identify Hanford miniature swine as an appropriate animal model for further investigation of TEABO technologies. Swine are used extensively in biomedical research and have already been established as physiologically comparable organisms [9][10][11][12][13][14][15]. This study provides additional evidence that the anatomical relationship between the thoracic esophagus and descending aorta in Hanford miniature swine is both comparable to humans and suitable for evaluating anatomically sensitive trans-esophageal strategies such as TEABO.…”

Section: Discussionmentioning

confidence: 77%

“…Domestic swine (Sus scrofa domestica) are used extensively in research settings. They have similarities in gross anatomy, size, and vasculature [9][10][11]. Functionally, their cardiovascular, digestive, dermal, and urinary processes are analogous to humans [12].…”

Section: Resultsmentioning

confidence: 99%

Morphometric Analysis of the Aorto-Esophageal Relationship in Swine for Trans-Esophageal Aortic Blood Flow Occlusion

Savidge

Abdou

Edwards

et al. 2022

JEVTM

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Background Trans-esophageal aortic blood flow occlusion (TEABO) is an emerging technology undergoing laboratory research that offers a strategy for temporary hemorrhage control. The purpose of this study was to evaluate the anatomical relationship between the esophagus and descending thoracic aorta in two breeds of swine to support a porcine model for future TEABO investigations. Methods Thoracoabdominal CT scans were compared in Hanford miniature swine and Yorkshire swine. Measurements were taken at the five vertebral levels proximal to the gastroesophageal junction. Data collected included the distance between the center of the esophagus and the center of the descending aorta, the angle between the vertebral column, descending aorta, and esophagus, and the length the thoracic esophagus travels anteriorly to the descending aorta. Results Ten Hanford swine and ten Yorkshire swine were compared. In Hanford swine, the distal thoracic esophagus travels anteriorly to the descending aorta for a mean distance of 11.5 ± 2.3 cm. In Yorkshire swine, the thoracic esophagus travels to the right of the descending aorta. The mean angle between the vertebral body, descending aorta, and esophagus was 79.6 to 97.8 degrees higher in Hanfords compared to Yorkshires (p<0.0001 at all five vertebral levels compared). The mean distance between the esophagus and descending aorta was 0.2 to 0.6 cm higher in Hanfords compared to Yorkshires with a significant difference found at only two vertebral levels (p=0.01 and p=0.02). Conclusion Hanford miniature swine possess an aorto-esophageal relationship comparable to humans and should be the preferred animal model for TEABO studies.

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“…A second study compared the diameter ratios and bifurcation angles of the iliofemoral arteries in mixed-Landrace crossbred swine and Yucatan minipigs with those of the human carotid arteries by using angiographic images, with results suggesting that both Landrace and Yucatan iliofemoral arteries are suitable animal models for human carotid interventions. 1 However, angiography is an invasive procedure and is unsuitable for preprocedural screening and selection of animals. Furthermore, experimental manipulations required to perform angiography (e.g., passing guidewires and catheters) can induce vasoconstriction, 2 leading to inaccurate measurement of the arteries.…”

mentioning

confidence: 99%

Measurement of the Luminal Diameter of Peripheral Arterial Vasculature in Yorkshire×Landrace Swine by Using Ultrasonography and Angiography

Zuo¹,

Koh²,

Charles³

et al. 2020

j am assoc lab anim sci

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To select animals of appropriate size for preclinical studies of cardiovascular devices, reference knowledge of the cardiovascularanatomy relative to body weight is crucial. We measured the luminal diameters of the arteries (carotid, femoral, and iliac arteries) that are the common access vessels for endovascular and vascular procedures in Yorkshire×Landrace swine. Measurements were performed by using both ultrasound and angiographic methods and were correlated with body weight. Results showed no statistically significant difference between the left and right vessels in the diameters of the carotid,femoral, and iliac arteries. The diameters of the measured arteries showed high correlation with animal weight in pigs thatweighed less than 70 kg.

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Similarity of the Swine Vasculature to the Human Carotid Bifurcation: Analysis of Arterial Diameters

Cited by 13 publications

References 22 publications

Development of an Intravascular Doppler Optical Coherence Tomography Imaging Technique for Neurovascular Applications

Development of an Intravascular Doppler Optical Coherence Tomography Imaging Technique for Neurovascular Applications

Morphometric Analysis of the Aorto-Esophageal Relationship in Swine for Trans-Esophageal Aortic Blood Flow Occlusion

Measurement of the Luminal Diameter of Peripheral Arterial Vasculature in Yorkshire×Landrace Swine by Using Ultrasonography and Angiography

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