Similarities in Acquired Factors Related to Postmenopausal Osteoporosis and Sarcopenia

Sirola, Joonas; Kröger, Heikki

doi:10.4061/2011/536735

Cited by 50 publications

(52 citation statements)

References 216 publications

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“…The mechanical load may lead to bone strengthening with mobility-induced weight-bearing stress [3]. Thus, our results are in accordance to previous studies that demonstrated that weight loss may increase the bone turnover, suggesting that body weight enhances the differentiation of osteoblasts and increase osteoblastic bone formation besides attenuates osteoclastic activity [13,14,15,18].…”

Section: Discussionsupporting

confidence: 82%

“…Beyond the bone mass decline, decrements on blood levels of oestrogen also may cause age-related muscle mass loss [1,3,7,8]. According to previous studies the relative muscle skeletal index (RMSI) reduces approximately 1.1 kg/decade [9].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies suggested that the early identification of risk factors for the development of osteoporosis should reduce medical complications, which are associated with increased morbidity and mortality in older women [1][2][3]. With respect of this, investigations focused on find out how the aging, postmenopausal changes, muscle and bone loss may be associated and how these factors interfere on functional performance and strength are important to reduce the risk of falls, bone fractures and incapacity in older women [10].…”

Section: Introductionmentioning

confidence: 99%

“…Osteoporosis is a common and costly disease, characterized by the decline of bone mineral density and changes on bone microarchitecture, which leads to weakness on the resistance of bones and higher risk of fractures in older women [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Impact of First 10 Years of Post Menopause on Muscle Function, Muscle Mass and Bone Mineral Density in Adult Women

Kochi¹,

Marques

Costa³

et al. 2015

J Osteopor Phys Act

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of First 10 Years of Post Menopause on Muscle Function, Muscle Mass and Bone Mineral Density in Adult Women

Kochi¹,

Marques

Costa³

et al. 2015

J Osteopor Phys Act

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“…In fact, notwithstanding enthusiastic reviews relating vitamin D status to muscle strength and function (80,81) , in addition to the cautious approach of the IOM report in relation to vitamin D status and muscle function there are two other important issues that need to be resolved.…”

Section: Vitamin D: Strength Preservation In Musclementioning

confidence: 99%

Nutrition and sarcopenia: evidence for an interaction

Millward

2012

Proc. Nutr. Soc.

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Nutritional interventions that might influence sarcopenia, as indicated by literature reporting on sarcopenia per se as well as dynapenia and frailty, are reviewed in relation to potential physiological aetiological factors, i.e. inactivity, anabolic resistance, inflammation, acidosis and vitamin D deficiency. As sarcopenia occurs in physically active and presumably well-nourished populations, it is argued that a simple nutritional aetiology is unlikely and unequivocal evidence for any nutritional influence is extremely limited. Dietary protein is probably the most widely researched nutrient but only for frailty is there one study showing evidence of an aetiological influence and most intervention studies with protein or amino acids have proved ineffective with only a very few exceptions. Fish oil has been shown to attenuate anabolic resistance of muscle protein synthesis in one study. There is limited evidence for a protective influence of antioxidants and inducers of phase 2 proteins on sarcopenia, dynapenia and anabolic resistance in human and animal studies. Also fruit and vegetables may protect against acidosis-induced sarcopenia through their provision of dietary potassium. While severe vitamin D deficiency is associated with dynapenia and sarcopenia, the evidence for a beneficial influence of increasing vitamin D status above the severe deficiency level is limited and controversial, especially in men. On this basis there is insufficient evidence for any more specific nutritional advice than that contained in the general healthy lifestyle-healthy diet message: i.e. avoiding inactivity and low intakes of food energy and nutrients and maintain an active lifestyle with a diet providing a rich supply of fruit and vegetables and frequent oily fish. Aging: Dynapenia: Inactivity: Anabolic resistance: DietIn a recent consensus paper sarcopenia (1) was defined as the age-associated loss of skeletal muscle mass and function, a complex syndrome associated with muscle mass loss alone or in conjunction with increased fat mass. It was argued that although cachexia may be a component of sarcopenia, the two conditions are not the same. What was not discussed in this paper was the difference between sarcopenia and dynapenia which is important in terms of the clinical relevance of the condition. Thus Jansonn (2) points out that the data on the functional implications of sarcopenia are inconsistent, possibly because we do not always recognise the distinction between sarcopenia, loss of muscle mass and dynapenia and loss of muscle strength. These, he argues, are physiologically different with dynapenia the main predictor of functional impairment and/or physical disability, chronic disease and mortality risk, to the extent that research and clinical emphasis should be placed more on dynapenia than on sarcopenia. In fact this argument can, to some extent be extended to include frailty, a much more general term for a collection

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High Postural Sway Is an Independent Risk Factor for Osteoporotic Fractures but Not for Mortality in Elderly Women

Qazi

Sirola

Kröger

et al. 2019

Journal of Bone and Mineral Research

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The aim of this prospective cohort study was to investigate the independent effect of postural sway on overall fracture and osteoporotic fracture risk after controlling for other established fracture risk factors. As a secondary outcome, mortality was also investigated. The study sample is a stratified random sample of 1568 women born between 1932 and 1941, residing in Kuopio province, eastern Finland. Fracture data were obtained through study questionnaires and verified through hospital records. Mortality data were verified through the National Registry. Using static posturography, postural sway was recorded for 1568 women at the fifth year of follow‐up in 1994 through 1997. Mediolateral (ML), anteroposterior (AP), and total sway parameters were used for analysis. Mean follow‐up time for any fractures, osteoporotic fractures, and mortality was 10.6, 11.4, and 17.5 years, respectively. After adjustment, subjects in the highest quartile of ML sway (HR, 2.0; 95% CI, 1.5 to 2.8) and total sway (HR, 1.6; 95% CI, 1.2 to 2.2) had a higher risk for any fracture. Osteoporotic fracture risk was also higher in the fourth quartile of ML sway (HR, 1.9; 95% CI, 1.1 to 3.0) and total sway (HR, 1.7; 95% CI, 1.0 to 2.8). The models were adjusted for fracture risk assessment tool risk factors and leg‐extension strength. Further, women having both lowest bone density and highest postural sway were at 4.9 (95% CI, 2.6 to 9.5) times higher risk of overall fracture and 11.8 (95% CI, 2.7 to 51.3) times higher risk for osteoporotic fracture in comparison with subjects having highest bone density and lowest postural sway. The association between postural sway and mortality was not significant after adjustment. In conclusion, high postural sway is an independent risk factor for any fractures as well as for osteoporotic fractures. A combination of low bone density and high postural sway poses even higher fracture risk than either factor alone. Postural sway does not predict mortality independently. © 2019 American Society for Bone and Mineral Research.

show abstract

Similarities in Acquired Factors Related to Postmenopausal Osteoporosis and Sarcopenia

Cited by 50 publications

References 216 publications

Impact of First 10 Years of Post Menopause on Muscle Function, Muscle Mass and Bone Mineral Density in Adult Women

Impact of First 10 Years of Post Menopause on Muscle Function, Muscle Mass and Bone Mineral Density in Adult Women

Nutrition and sarcopenia: evidence for an interaction

High Postural Sway Is an Independent Risk Factor for Osteoporotic Fractures but Not for Mortality in Elderly Women

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