“…Yet these lipophilic alkaloids can also act rather unspecifically, e.g., by labilizing membranes (causing increased fluidity and channel activity), as shown for veratridine [2,7,42,50]. Veratridine is frequently assumed to act from outside the cell, but it may also become active from inside the cell [19,22], whereby it would have to penetrate the cell membrane [8,22].…”