Similarities and differences between doxycycline and minocycline: clinical and antimicrobial stewardship considerations

Cunha, Burke A.; Baron, Jeffrey; Cunha, Cheston B.

doi:10.1007/s10096-017-3081-x

Cited by 20 publications

(11 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the same time, the doxycycline (tetracycline class) and gentamicin (aminoglycoside class) were the most effective against MRSA in our study and both showed a definitive additive effect with PEF. Both antibiotics feature a similar mechanism of effect, that is, target protein synthesis inhibition through binding to 30S ribosomal subunit [ 35 , 36 ]. Therefore, the mechanism of resistance is notably related to efflux pumps, while membrane permeabilization (in our case by electroporation) can significantly alter the drug access [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation

et al. 2018

View full text Add to dashboard Cite

Treatment of bacteria-associated infections is complicated and antibiotic treatment alone is often inadequate to overcome biofilm infections. Physical methods allow overcoming this problem and propose solutions that are non-dependent on drug resistance. In this work, we investigated the feasibility of pulsed electric fields for sensitization of MRSA to common antibiotics. We analyzed the efficacy of inactivation of methicillin-resistant Staphylococcus aureus in 5–20 kV/cm electric field separately and in combination with gentamicin, doxycycline, ciprofloxacin, sulfamethoxazole, and vancomycin. Combined treatment allowed using up to 1000-fold smaller concentrations of antibiotics to induce the same inactivation of S. aureus.

show abstract

Section: Discussionmentioning

confidence: 99%

Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation

et al. 2018

View full text Add to dashboard Cite

show abstract

“…19 Similar to other tetracyclines, sarecycline exerts its antibacterial effect mainly as a ribosomal protein inhibitor. 19,25 Sarecycline has shown activity against C. acnes that is comparable to doxycycline and minocycline (Table 1). Importantly, the minimum inhibitory concentration (MIC 90 ) for sarecycline was 0.5 μg/mL against both methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) strains of S. aureus and 2 µg/mL against both methicillin-susceptible and -resistant S. epidermidis, only twofold less active than doxycycline and minocycline.…”

Section: Gram-positive Bacteriamentioning

confidence: 99%

“…Minocycline is a lipophilic tetracycline capable of crossing the blood-brain barrier and is more lipophilic than doxycycline and tetracycline. 25,30 Sarecycline has demonstrated low potential for crossing the blood-brain barrier in an animal (rat) model study (Table 4). 29 It is believed that crossing of the blood-brain barrier contributes to an increased risk of vestibular side effects such as dizziness and vertigo, which are seen more commonly with minocycline as compared to other tetracyclines.…”

Section: Blood-brain Barriermentioning

confidence: 99%

<p>Sarecycline: A Review of Preclinical and Clinical Evidence</p>

Moore¹,

Rosso²,

Johnson³

et al. 2020

CCID

View full text Add to dashboard Cite

Sarecycline is a tetracycline-derived oral antibiotic, specifically designed for acne, and is approved by the Food and Drug Administration (FDA) in 2018 for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris (AV) in patients 9 years of age and older. It has been decades since a novel systemic antibiotic was approved to treat AV, a disease that affects up to 90% of teenagers and young adults worldwide and lasts well into adulthood. Sarecycline holds promise to yield fewer side effects than other commonly used broad-spectrum tetracyclines, including minocycline and doxycycline. The narrower spectrum of antibacterial activity of sarecycline, which specifically targets C. acnes and some Gram-positive bacteria with little or no activity against Gram-negative bacteria, suggests not only the potential for reduced emergence of antibiotic-resistant bacterial strains but also less disruption of the human gut microflora. Here, we review the key preclinical and clinical evidence on sarecycline.

show abstract

“…Up to one third of ColdU patients have been reported to benefit from treatment with doxycycline, and 19% showed full remission ( 58 ), but the mechanisms for such improvements have not yet been explained. Furthermore, doxycycline is also effective against Mycoplasma pneumoniae ( 59 ) and Streptococcus pneumoniae ( 60 ).…”

Section: Discussionmentioning

confidence: 99%

Cold Agglutinins and Cryoglobulins Associate With Clinical and Laboratory Parameters of Cold Urticaria

et al. 2021

View full text Add to dashboard Cite

Mast cell-activating signals in cold urticaria are not yet well defined and are likely to be heterogeneous. Cold agglutinins and cryoglobulins have been described as factors possibly associated with cold urticaria, but their relevance has not been explained. We performed a single-center prospective cohort study of 35 cold urticaria patients. Cold agglutinin and cryoglobulin test results, demographics, detailed history data, cold stimulation test results, complete blood count values, C-reactive protein, total immunoglobulin E levels, and basal serum tryptase levels were analyzed. Forty six percent (n = 16) of 35 tested patients had a positive cold agglutinin test and 27% (n = 9) of 33 tested patients had a positive cryoglobulin test. Cold agglutinin positive patients, when compared to cold agglutinin negative ones, were mainly female (P = 0.030). No gender-association was found for cryoglobulins. A positive cold agglutinin test, but not a positive cryoglobulin test, was associated with a higher rate of reactions triggered by cold ambient air (P = 0.009) or immersion in cold water (P = 0.041), and aggravated by increased summer humidity (P = 0.007). Additionally, patients with a positive cold agglutinin test had a higher frequency of angioedema triggered by ingestion of cold foods or drinks (P = 0.043), and lower disease control based on Urticaria Control Test (P = 0.023). Cold agglutinin levels correlated with erythrocyte counts (r = −0.372, P = 0.028) and monocyte counts (r = −0.425, P = 0.011). Cryoglobulin concentrations correlated with basal serum tryptase levels (r = 0.733, P = 0.025) and cold urticaria duration (r = 0.683, P = 0.042). Results of our study suggest that cold agglutinins and cryoglobulins, in a subpopulation of cold urticaria patients, are linked to the course and possibly the pathogenesis of their disease.

show abstract

Similarities and differences between doxycycline and minocycline: clinical and antimicrobial stewardship considerations

Cited by 20 publications

References 52 publications

Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation

Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation

<p>Sarecycline: A Review of Preclinical and Clinical Evidence</p>

Cold Agglutinins and Cryoglobulins Associate With Clinical and Laboratory Parameters of Cold Urticaria

Contact Info

Product

Resources

About