&lt;p&gt;Sarecycline: A Review of Preclinical and Clinical Evidence&lt;/p&gt;

Moore, Angela; Rosso, James Del; Johnson, Jerry J.; Grada, Ayman

doi:10.2147/ccid.s190473

Cited by 11 publications

(16 citation statements)

References 33 publications

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“…The FDA-approved sarecycline is used for treating acne vulgaris in patients aged nine years or above, demonstrating efficacy against moderate-to-severe, inflammatory, or non-inflammatory (comedones) forms. In addition, due to its targeted action on Cutinebacterium acnes and low blood-brain penetration, sarecycline has a good safety profile (minimal side effects), low potential to induce bacterial resistance, and also potentially low impact on the gut microbiota when compared to the broad-spectrum doxycycline and minocycline [154,155].…”

Section: Therapeutic Use Of the New Tetracyclinesmentioning

confidence: 99%

The Development of Third-Generation Tetracycline Antibiotics and New Perspectives

Rusu

Buta

2021

Pharmaceutics

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The tetracycline antibiotic class has acquired new valuable members due to the optimisation of the chemical structure. The first modern tetracycline introduced into therapy was tigecycline, followed by omadacycline, eravacycline, and sarecycline (the third generation). Structural and physicochemical key elements which led to the discovery of modern tetracyclines are approached. Thus, several chemical subgroups are distinguished, such as glycylcyclines, aminomethylcyclines, and fluorocyclines, which have excellent development potential. The antibacterial spectrum comprises several resistant bacteria, including those resistant to old tetracyclines. Sarecycline, a narrow-spectrum tetracycline, is notable for being very effective against Cutinebacterium acnes. The mechanism of antibacterial action from the perspective of the new compound is approached. Several severe bacterial infections are treated with tigecycline, omadacycline, and eravacycline (with parenteral or oral formulations). In addition, sarecycline is very useful in treating acne vulgaris. Tetracyclines also have other non-antibiotic properties that require in-depth studies, such as the anti-inflammatory effect effect of sarecycline. The main side effects of modern tetracyclines are described in accordance with published clinical studies. Undoubtedly, this class of antibiotics continues to arouse the interest of researchers. As a result, new derivatives are developed and studied primarily for the antibiotic effect and other biological effects.

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Section: Therapeutic Use Of the New Tetracyclinesmentioning

confidence: 99%

The Development of Third-Generation Tetracycline Antibiotics and New Perspectives

Rusu

Buta

2021

Pharmaceutics

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“…33 In an animal study, sarecycline showed a very low likelihood to cross the blood-brain barrier and this may explain the low rates of vestibular side effects observed in the clinical trials. [34][35][36] Although no head-to-head studies exist with other oral antibiotics, some adverse events with sarecycline seem to be lessfrequently reported than with other tetracyclines. A recently published systematic review for oral tetracycline antibiotics (sarecycline, minocycline, doxycycline, and tetracycline) in acne evaluated the efficacy and rates of adverse events for each of them.…”

Section: Narrow-and Broad-spectrum Antibioticsmentioning

confidence: 99%

Treating acne with the tetracycline class of antibiotics: A review

Graber

2021

Dermatological Reviews

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Acne, one of the most common dermatologic conditions seen by dermatologists, is frequently treated with oral antibiotics. As such, dermatologists prescribe more antibiotics than any other specialty, the majority of which are of the tetracycline class. This family of antibiotics includes tetracycline, doxycycline, minocycline, and sarecycline. Although linked by a similar mechanism of action, each agent has unique characteristics that should be considered carefully. Sarecycline, recently approved by the United States Food and Drug Administration, is a narrow-spectrum antibiotic and acts primarily on cutaneous bacteria such as Cutibacterium acnes. In contrast, tetracycline, doxycycline, and minocycline are broad-spectrum antibioticsindiscriminately inhibiting bacteria in both the skin and gastrointestinal tract. Rising concerns about antibiotic resistance and the need for antibiotic stewardship may make a narrow-spectrum antibiotic a more attractive therapeutic choice for the acne patient. It is vital that the clinician understand the pros and cons of each tetracycline agent so as to optimally serve our acne population.

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“…It was approved by the FDA in 2018 for the treatment of inflammatory conditions associated with moderate to severe non-nodular acne. 66 Sarecycline has strong anti-inflammatory activity against GPB, such as Cutibacterium acnes , and has minimal anti-inflammatory activity against aerobic GNB. 67 It has a low resistance rate in tetracycline-resistant S. aureus , as well as erythromycin-resistant and clindamycin-resistant bacteria.…”

Section: Progress In Research and Development Of Drugs Against Drug-resistant Bacteriamentioning

confidence: 99%

Development and Research Progress of Anti-Drug Resistant Bacteria Drugs

Cui¹,

Lü²,

Yue³

2021

IDR

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Bacterial resistance has become increasingly serious because of the widespread use and abuse of antibiotics. In particular, the emergence of multidrug-resistant bacteria has posed a serious threat to human public health and attracted the attention of the World Health Organization (WHO) and the governments of various countries. Therefore, the establishment of measures against bacterial resistance and the discovery of new antibacterial drugs are increasingly urgent to better contain the emergence of bacterial resistance and provide a reference for the development of new antibacterial drugs. In this review, we discuss some antibiotic drugs that have been approved for clinical use and a partial summary of the meaningful research results of anti-drug resistant bacterial drugs in different fields, including the antibiotic drugs approved by the FDA from 2015 to 2020, the potential drugs against drug-resistant bacteria, the new molecules synthesized by chemical modification, combination therapy, drug repurposing, immunotherapy and other therapies.

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<p>Sarecycline: A Review of Preclinical and Clinical Evidence</p>

Cited by 11 publications

References 33 publications

The Development of Third-Generation Tetracycline Antibiotics and New Perspectives

The Development of Third-Generation Tetracycline Antibiotics and New Perspectives

Treating acne with the tetracycline class of antibiotics: A review

Development and Research Progress of Anti-Drug Resistant Bacteria Drugs

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