Similarities and differences between Behçet's disease and Crohn's disease

Abstract

Behçet's disease (BD) is a chronic inflammatory condition with multisystem involvement. Approximately 10%-15% of patients present with gastrointestinal involvement. Involved sites and the endoscopic view usually resemble Crohn's disease (CD). In addition to intestinal involvement, oral mucosa, the eyes, skin, and joints are commonly affected. No pathognomonic laboratory test is available for the diagnosis of either disease. Management approaches are also similar in various aspects. Differentiating BD from CD is highly challenging. In this article, the similarities and differences between BD and CD in terms of epidemiology, etiopathogenesis, clinical and imaging findings, and histopathological and therapeutic approaches are reviewed.

Oral Manifestations of Inflammatory Bowel Diseases: Two Case Reports

“…8 Smoking may be a risk factor for CD, differently from UC. 2,3,5,[7][8][9] In both cases reported here, the patients were males who had never smoked.…”

“…In addition, while in the West CD is slightly more prevalent in women, in the East men are more often diagnosed with the disease. 2,3,5,[7][8][9] In turn, UC is an immune condition that results from an abnormal interaction between the colon microbiota and the intestinal mucosa immune cells in a genetically susceptible individual. Equally prevalent in both genders, UC is slightly more prevalent in men in the West.…”

Juvenile Behсet's Disease: Clinical Observation

“…Кроме того, известно, что аутоиммунные заболевания ассоциируются с молекулами главного комплекса гистосовместимости (Human leukocyte antigens, HLA) II класса, тогда как болезнь Бехчета -с антигеном I класса (HLA-B5) [41]. В пользу аутоиммунной природы болезни свидетельству-ют активация B лимфоцитов и обнаружение аутоантител против поверхностных клеточных антигенов -антиэн-дотелиальных, антилимфоцитарных [42], антител против альфа-тропомиозина, альфа-энолазы, кинектина [43,44] и белка теплового шока (HSP60) [45].…”

Serum visfatin levels in Behçet's disease

“…Etiyolojisi tam olarak aydınlatılamamıştır. BH'nin etyopatogenezi ile ilgili günümüzde yaygın olan görüş genetik olarak hastalığa yatkın bireyde, çevresel faktör olarak enfeksiyon ajanları veya ısı şok proteinleri ile immün sisteminin uyarılarak hastalığın başladığı yönündedir [2][3][4] . İnfeksiyöz ajanlardan en çok üzerinde durulan HSV-1'dir (Herpes simplex virüs -1).…”

“…BH alevlenme ve iyilik dönemleri ile seyreden kronik enflamatuvar bir vaskülittir 1 . Genetik faktörler ve HLA tipleri, infeksiyöz ajanlar, ısı şok proteinleri, endotel hücre disfonksiyonu, oksidatif stres, self-antijenler ile humoral ve hücresel immünitede değişiklikler hastalığın etiyolojisinde yer almaktadır [2][3][4] . T hücreleri ve nötrofillerin aktivasyonu hastalığın patogenezinde önemli role sahiptir.…”