Similar to Those Who Are Breastfed, Infants Fed a Formula Containing 2′-Fucosyllactose Have Lower Inflammatory Cytokines in a Randomized Controlled Trial

Goehring, Karen C.; Marriage, Barbara J.; Oliver, Jeffery; Wilder, Julie A.; Barrett, Edward G.; Buck, Rachael H.

doi:10.3945/jn.116.236919

Cited by 221 publications

(233 citation statements)

References 45 publications

Supporting

Mentioning

215

Contrasting

Unclassified

Order By: Relevance

“…Recent studies have examined the effects of infant formula supplemented with a specific HMO species (Donovan & Comstock 2016). Goehring et al (2016) reported that infants fed a formula containing 2′-FL had lower levels of inflammatory cytokines compared to those fed, which is similar to infants that are breastfed. Steenhout et al (2016) demonstrated that infants fed formula supplemented with 2′-FL and LNnT possessed a stool microbiota that more closely resembled that of breastfed infants.…”

Section: Diets Supplemented With Exogenous Milk Oligosaccharidesmentioning

confidence: 78%

Milk Glycans and Their Interaction with the Infant-Gut Microbiota

Kirmiz

Robinson

Shah

et al. 2018

Annu. Rev. Food Sci. Technol.

View full text Add to dashboard Cite

Human milk is a unique and complex fluid that provides infant nutrition and delivers an array of bioactive molecules that serve various functions. Glycans, abundant in milk, can be found as free oligosaccharides or as glycoconjugates. Milk glycans are increasingly linked to beneficial outcomes in neonates through protection from pathogens and modulation of the immune system. Indeed, these glycans influence the development of the infant and the infant-gut microbiota. Bifidobacterium species commonly are enriched in breastfed infants and are among a limited group of bacteria that readily consume human milk oligosaccharides (HMOs) and milk glycoconjugates. Given the importance of bifidobacteria in infant health, numerous studies have examined the molecular mechanisms they employ to consume HMOs and milk glycans, thus providing insight into this unique enrichment and shedding light on a range of translational opportunities to benefit at-risk infants.

show abstract

Section: Diets Supplemented With Exogenous Milk Oligosaccharidesmentioning

confidence: 78%

Milk Glycans and Their Interaction with the Infant-Gut Microbiota

Kirmiz

Robinson

Shah

et al. 2018

Annu. Rev. Food Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Although safe for infants, the 2ʹFL treatment provided no net dif ference in weight, length, head circumference and other measures compared with human milk over a 4 month period 44 . In another study by the same group, infants fed formula with 2ʹFL plus GOS had immune responses simi lar to breast fed infants in that both groups had lower levels of inflammatory cytokines than infants fed formula plus GOS 45 . However, effects on the microbiota were not reported in this study.…”

Section: Box 2 | Justification For the New Definition Of Prebioticsmentioning

confidence: 87%

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Gibson

Hutkins

Sanders³

et al. 2017

Nat Rev Gastroenterol Hepatol

3,475

2,428

View full text Add to dashboard Cite

In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to review the definition and scope of prebiotics. Consistent with the original embodiment of prebiotics, but aware of the latest scientific and clinical developments, the panel updated the definition of a prebiotic: a substrate that is selectively utilized by host microorganisms conferring a health benefit. This definition expands the concept of prebiotics to possibly include non-carbohydrate substances, applications to body sites other than the gastrointestinal tract, and diverse categories other than food. The requirement for selective microbiota-mediated mechanisms was retained. Beneficial health effects must be documented for a substance to be considered a prebiotic. The consensus definition applies also to prebiotics for use by animals, in which microbiota-focused strategies to maintain health and prevent disease is as relevant as for humans. Ultimately, the goal of this Consensus Statement is to engender appropriate use of the term 'prebiotic' by relevant stakeholders so that consistency and clarity can be achieved in research reports, product marketing and regulatory oversight of the category. To this end, we have reviewed several aspects of prebiotic science including its development, health benefits and legislation

show abstract

“…Arslanoglu et al () suggested that early nutritional intervention with GOS/FOS seems to modulate the infant's immune system, leading to a protective effect against allergy and infection. In addition, 2′FL stimulated immune development in infants as observed by lower plasma cytokine profiles, such as IL‐1, IL‐6, and TNF‐α (Goehring et al, ).…”

Section: Microbiota‐dependent Effects Of Dietary Fibre On Gut Homeostmentioning

confidence: 99%

Microbiota‐dependent and ‐independent effects of dietary fibre on human health

Cai

Folkerts

et al. 2019

British J Pharmacology

View full text Add to dashboard Cite

Dietary fibre, such as indigestible oligosaccharides and polysaccharides, occurs in many foods and has gained considerable importance related to its beneficial effects on host health and specific diseases. Dietary fibre is neither digested nor absorbed in the small intestine and modulates the composition of the gut microbiota. New evidence indicates that dietary fibre also interacts directly with the epithelium and immune cells throughout the gastrointestinal tract by microbiota‐independent effects. This review focuses on how dietary fibre improves human health and the reported health benefits that are connected to molecular pathways, in (a) a microbiota‐independent manner, via interaction with specific surface receptors on epithelial and immune cells regulating intestinal barrier and immune function, and (b) a microbiota‐dependent manner via maintaining intestinal homeostasis by promoting beneficial microbes, including Bifidobacteria and Lactobacilli, limiting the growth, adhesion, and cytotoxicity of pathogenic microbes, as well as stimulating fibre‐derived microbial short‐chain fatty acid production. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

show abstract

Similar to Those Who Are Breastfed, Infants Fed a Formula Containing 2′-Fucosyllactose Have Lower Inflammatory Cytokines in a Randomized Controlled Trial

Abstract: Our data indicate that infants fed formula supplemented with 2'-FL exhibit lower plasma and ex vivo inflammatory cytokine profiles, similar to those of a breastfed reference group. This trial was registered at clinicaltrials.gov as NCT01808105.

Cited by 221 publications

References 45 publications

Milk Glycans and Their Interaction with the Infant-Gut Microbiota

Milk Glycans and Their Interaction with the Infant-Gut Microbiota

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Microbiota‐dependent and ‐independent effects of dietary fibre on human health

Contact Info

Product

Resources

About