Similar Fecal Microbiota Signatures in Patients With Diarrhea-Predominant Irritable Bowel Syndrome and Patients With Depression

Beneficial effect of butyrate‐producing Lachnospiraceae on stress‐induced visceral hypersensitivity in rats

“…Similarly, the abundance of Prevotella , a major genus belonging to the Prevotellaceae, was also elevated in WAS rats. A previous clinical study classified all enrolled subjects into three enterotypes, and IBS patients were assigned to Prevotella ‐dominant (25%) and Bacteroides ‐dominant (60%) types. These results support the potentially important role of Prevotellaceae and Prevotella in IBS morbidity.…”

“…Perturbations in gut microbiota contribute to the development of intestinal disorders, including irritable bowel syndrome (IBS). IBS patients harbor altered gut microbiota in comparison with those of healthy controls . The absence or disruption of gut microbes can significantly influence visceral pain perception, leading to visceral hypersensitivity.…”

“…IBS patients harbor altered gut microbiota in comparison with those of healthy controls. 1,2 The absence or disruption of gut microbes can significantly influence visceral pain perception, leading to visceral hypersensitivity. In particular, germ-free mice exhibited increased visceral pain responses when exposed to colorectal distension (CRD) stimuli, and visceral hypersensitivity was normalized after microbial colonization.…”

The gut microbiota and psychiatric illness

“…29 A group recently reported that fecal microbiota signatures are similar be tween patients with depression and those with IBS in that they were less diverse than samples from controls and had similar abundances of alterations. 30 Although the gut-brain axis has been widely recognized, the nature of these interactions remains poorly understood. Studying psychiatric symptoms in people with and without GI disease may provide further insight into associations between diet, the microbiome, intestinal physiology and the neurobiology underlying some psychiatric illnesses.…”

The development and tendency of depression researches: Viewed from the microbiota-gut-brain axis

“…降低 [75,111] ; 双歧杆菌属(Bifidobacterium)和乳酸杆菌 属(Lactobacillus)含量降低 [112] . 虽然这些研究都发现, 抑郁症患者与健康个体的粪便菌群不同, 但具体差异 部分仍有分歧 [76,113,114] 后, 这种风险提高影响依然存在 [124,125] .…”