Silymarin inhibits melanin synthesis in melanocyte cells

Choo, Soo‐Jin; Ryoo, In‐Ja; Kim, Young‐Hee; Xu, Guang-Hwa; Kim, Won‐Gon; Kim, Kiho; Moon, Shinje; Son, Eui Dong; Bae, KiHwan; Yoo, Ick Dong

doi:10.1211/jpp/61.05.0016

Cited by 10 publications

(15 citation statements)

References 29 publications

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“…Silymarin can also reduce melanin production by its antioxidant effect and inhibition of L‐dopa oxidation activity of tyrosinase. In addition, it has been found that silymarin decreases the expression of tyrosinase protein …”

Section: Discussionmentioning

confidence: 99%

“…Complete dermatological examination was also performed to assess Fitzpatrick skin type, pattern of melasma (centro-facial, malar, or mandibular), melasma type (epidermal, dermal, or mixed) and severity as assessed by melasma area and severity index score (MASI Score). 4 The severity of melasma was divided according to MASI score into mild (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16), moderate (>16-32), and severe (>32-48).…”

Section: Patientsmentioning

confidence: 99%

“…Silymarin is derived from the milk thistle plant “Silybum marianum.” Silibinin, the main component of silymarin, has been found to have antioxidant properties. It decreases the hazardous effects of solar ultraviolet radiation and significantly prevents melanin production in a dose‐dependent manner without effect on cell viability …”

Section: Introductionmentioning

confidence: 99%

“…It decreases the hazardous effects of solar ultraviolet radiation and significantly prevents melanin production in a dose-dependent manner without effect on cell viability. 7,8 Hydroquinone (HQ) is the most popular and most extensively studied medication in the management of melasma. It inhibits melanogenesis by inhibiting tyrosinase enzyme, affects the formation, melanization, and degradation of melanosomes and modulates the membranous structures of melanocytes, causing necrosis of whole melanocytes.…”

mentioning

confidence: 99%

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Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study

Nofal

Ibrahim

Nofal

et al. 2018

J of Cosmetic Dermatology

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Section: Discussionmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study

Nofal

Ibrahim

Nofal

et al. 2018

J of Cosmetic Dermatology

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“…Silybum marianum L.) Downregulated tyrosinase protein in mouse melanocyte cell line (Choo et al, 2009). …”

Section: Silymarin (Milk Thistle Ormentioning

confidence: 99%

Antioxidant Defense and UV-Induced Melanogenesis: Implications for Melanoma Prevention

Panich¹

2011

Current Management of Malignant Melanoma

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A practical guide to over‐the‐counter treatments for hyperpigmentation

Jafry,

Guan,

Mohammad

2024

JEADV Clinical Practice

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Hyperpigmentation of the skin, defined as increased melanin in the epidermis, is a common condition associated with psychosocial impairment and decreased quality of life. Prescription options are often not covered by insurance and can be cost prohibitive. As such, many turn to over‐the‐counter (OTC) products for treatment. However, a plethora of options are available, which can be confusing. This review aims to evaluate the evidence for common ingredients found in OTC products for management of hyperpigmentation and provide guidance for optimal use to clinicians and consumers. To perform this review, a comprehensive literature search utilizing PubMed and Google Scholar was conducted to identify relevant studies on the clinico‐epidemiological aspects of hyperpigmentation, including postinflammatory hyperpigmentation (PIH), melasma and maturational hyperpigmentation, as well as on relevant OTC treatments. The efficacy and safety of OTC products were assessed based on available evidence, clinical trials and expert recommendations. Our results showed hyperpigmentation is more prevalent among individuals with darker skin types (Fitzpatrick skin phototypes III–VI). Due to limited insurance coverage and the high cost of prescription options, over‐the‐counter (OTC) treatments are widely used for managing postinflammatory hyperpigmentation (PIH). However, the lack of strict regulation by the US Food and Drug Administration (FDA) raises concerns about the safety and efficacy of these products. By critically evaluating the existing literature, this review offers practical, evidence‐based guidance for the selection and utilization of OTC products for the treatment of hyperpigmentation.

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Silymarin inhibits melanin synthesis in melanocyte cells

Abstract: This study suggests that the depigmenting effect of silymarin might be attributable to inhibition of tyrosinase expression and that silymarin may be useful as a natural skin-lightening agent.

Cited by 10 publications

References 29 publications

Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study

Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study

Antioxidant Defense and UV-Induced Melanogenesis: Implications for Melanoma Prevention

A practical guide to over‐the‐counter treatments for hyperpigmentation

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