Silymarin, an antioxidant flavonoid, protects the liver from the toxicity of the anticancer drug paclitaxel

Gür, Fatih Mehmet; Bilğiç, Sedat

doi:10.1016/j.tice.2023.102158

Cited by 6 publications

(5 citation statements)

References 72 publications

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“…High total bilirubin (T-Bil) revealed the temporary stress of the liver due to the administration of CP. The presence of Rv in the ternary complex significantly reduced the level of liver stress [48]. However, the Tukey HSD test values for the liver-related biochemical parameters revealed no significant differences between the groups in the present study based on a single injection technique.…”

Section: Discussioncontrasting

confidence: 70%

“…On the other hand, the antioxidantprotected group that was treated with the γ-CD/Rv/CP ternary complex had liver-related biochemical parameter values closer to the control group or even lower. The GOT/AST parameter value was 107 IU/L in the CP-treated group, much higher than the normal limit in healthy rats (32.8-53 IU/L) [45,48]. On the contrary, the control and γ-CD/Rv/CP ternary complex-treated groups had GOT/AST values of only 73.8 and 65.8 IU/L, respectively, which were in the normal range.…”

Section: Discussionmentioning

confidence: 72%

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Beneficial Effects of Resveratrol and γ-Cyclodextrin on the Hematological and Biochemical Parameters of Healthy Wistar Rats Treated with Cisplatin: A PCA Approach

Hădărugă,

Gârban,

Baltă

et al. 2023

Biomedicines

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It is well known that platinum-based antineoplastic agents, including cisplatin (CP), have side effects that limit their use. Nefrotoxicity, neurotoxicity, and hemolytic anemia are the most common side effects. There are few studies on the reduction in these effects that involves nanoencapsulation; however, almost none involve cyclodextrins (CDs). Changes in the hematological and biochemical parameters of healthy Wistar rats treated with solutions of γ-cyclodextrin/resveratrol/cisplatin (γ-CD/Rv/CP) ternary complexes are investigated for the first time. They are intraperitoneally injected with γ-CD/Rv/CP solutions containing 5 mg CP/kg.b.w. Single shots were administered to six groups of Wistar rats (six individuals for every group) using γ-CD/Rv/CP, γ-CD/CP, γ-CD/Rv complexes, as well as positive- and negative-control groups, respectively. Thirty-two hematological and biochemical parameters were evaluated from blood samples and used as input variables for the principal component analysis (PCA) discrimination of the groups. The best protection was obtained for the γ-CD/Rv/CP ternary complex, which determined closer biochemical values to the control group. These values significantly differ from those of the γ-CD/CP treated group, especially for the IP, UA, and T-Pro kidney-related biochemical parameters. This finding proves the beneficial influence of Rv during CP administration through CD-based carriers.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 72%

Beneficial Effects of Resveratrol and γ-Cyclodextrin on the Hematological and Biochemical Parameters of Healthy Wistar Rats Treated with Cisplatin: A PCA Approach

Hădărugă,

Gârban,

Baltă

et al. 2023

Biomedicines

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“…Furthermore, SM showed promising results as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions, including inflammation [239]. For example, SM was reported to protect the liver from the harmful effects of the anticancer drug paclitaxel, showing anti-inflammatory (TNF-α), anti-apoptotic and antioxidant effects [240]. Therefore, it could be concluded that the anti-inflammatory properties of SM/SB are key elements of health-promoting properties of these phytochemicals, and further research should pay more attention to the molecular mechanisms of the protective actions of this phytochemical.…”

Section: Discussionmentioning

confidence: 99%

Silymarin and Inflammation: Food for Thoughts

Surai,

Earle-Payne

2024

Antioxidants

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Inflammation is a vital defense mechanism, creating hostile conditions for pathogens, preventing the spread of tissue infection and repairing damaged tissues in humans and animals. However, when inflammation resolution is delayed or compromised as a result of its misregulation, the process proceeds from the acute phase to chronic inflammation, leading to the development of various chronic illnesses. It is proven that redox balance disturbances and oxidative stress are among major factors inducing NF-κB and leading to over-inflammation. Therefore, the anti-inflammatory properties of various natural antioxidants have been widely tested in various in vitro and in vivo systems. Accumulating evidence indicates that silymarin (SM) and its main constituent silibinin/silybin (SB) have great potential as an anti-inflammation agent. The main anti-inflammatory mechanism of SM/SB action is attributed to the inhibition of TLR4/NF-κB-mediated signaling pathways and the downregulated expression of pro-inflammatory mediators, including TNF-α, IL-1β, IL-6, IL-12, IL-23, CCL4, CXCL10, etc. Of note, in the same model systems, SM/SB was able to upregulate anti-inflammatory cytokines (IL-4, IL-10, IL-13, TGF-β, etc.) and lipid mediators involved in the resolution of inflammation. The inflammatory properties of SM/SB were clearly demonstrated in model systems based on immune (macrophages and monocytes) and non-immune (epithelial, skin, bone, connective tissue and cancer) cells. At the same time, the anti-inflammatory action of SM/SB was confirmed in a number of in vivo models, including toxicity models, nonalcoholic fatty liver disease, ischemia/reperfusion models, stress-induced injuries, ageing and exercising models, wound healing and many other relevant model systems. It seems likely that the anti-inflammatory activities of SM/SB are key elements on the health-promoting properties of these phytochemicals.

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“… 116 Additionally, Silibinin is an effective component of traditional Chinese medicine, used as a hepatoprotective agent in clinical therapy, and its phospholipid complex has been used in the clinical treatment of acute liver injury. 117 Further finding found that the Silibinin-phospholipid complex significantly diminished d-GalN/LPS-induced liver injury by enhancing the expression of miR-223-3p, and miR-223-3p directly targeted the 3’ UTR of NLRP3, thereby inhibiting the activation of the NLRP3 inflammasome and the expression of pyroptotic proteins to achieve hepatoprotective effects. 118 Curcumol is an effective active ingredient extracted from the genuine medicinal herb Curcuma kwangsiensis S. G. Lee et C. F. Liang in Guangxi, China, which is known for its ability to invigorate blood circulation and remove blood stasis, protect the liver, and have anti-inflammatory, cholagogic and antioxidant effects.…”

Section: Traditional Chinese Medicine and Its Active Ingredients Infl...mentioning

confidence: 96%

NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review

Deng,

Qin,

Qin

et al. 2024

JIR

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Pyroptosis is a novel pro-inflammatory mode of programmed cell death that differs from ferroptosis, necrosis, and apoptosis in terms of its onset and regulatory mechanisms. Pyroptosis is dependent on cysteine aspartate protein hydrolase (caspase)-mediated activation of GSDMD, NLRP3, and the release of pro-inflammatory cytokines, interleukin-1 (IL-1β), and interleukin-18 (IL-18), ultimately leading to cell death. Non-coding RNA (ncRNA) is a type of RNA that does not encode proteins in gene transcription but plays an important regulatory role in other post-transcriptional links. NcRNA mediates pyroptosis by regulating various related pyroptosis factors, which we termed the pyroptosis signaling pathway. Previous researches have manifested that pyroptosis is closely related to the development of liver diseases, and is essential for liver injury, alcoholic fatty liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), liver fibrosis, and liver cancer. In this review, we attempt to address the role of the ncRNA-mediated pyroptosis pathway in the above liver diseases and their pathogenesis in recent years, and briefly outline that TCM (Traditional Chinese Medicine) intervene in liver diseases by modulating ncRNA-mediated pyroptosis, which will provide a strategy to find new therapeutic targets for the prevention and treatment of liver diseases in the future.

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Silymarin, an antioxidant flavonoid, protects the liver from the toxicity of the anticancer drug paclitaxel

Cited by 6 publications

References 72 publications

Beneficial Effects of Resveratrol and γ-Cyclodextrin on the Hematological and Biochemical Parameters of Healthy Wistar Rats Treated with Cisplatin: A PCA Approach

Beneficial Effects of Resveratrol and γ-Cyclodextrin on the Hematological and Biochemical Parameters of Healthy Wistar Rats Treated with Cisplatin: A PCA Approach

Silymarin and Inflammation: Food for Thoughts

NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review

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